Basic Training at the Intersection of Innate and Adaptive Immunity in Disease

描述(由申请人提供)：在这份申请中，我们请求每年资助6名学生参加我们在华盛顿大学免疫学系的博士前培训项目，Pamela Fink博士担任项目主任，Michael Bevan博士担任联席主任。这一新的申请反映了我们系的悠久历史，可以追溯到1989年成立，创始成员来自生物化学、分子生物学、传染病研究和基础免疫学背景。我们的系教员已经成长为包括基础研究专家以及研究和治疗人类传染病、自身免疫和免疫缺陷的临床医生。我们的培训计划将教学课程与学生主导的讨论小组和严格的资格审查和普通考试相结合，目标是培养下一代能够清晰地思考、写作和表达关键科学问题以及如何解决这些问题的科学家。我们的学生来自我们自己的免疫学研究生项目、密歇根大学分子和细胞生物学研究生项目以及医学科学家培训项目。这些学生受益于威斯康星大学及其附属机构丰富、多样和互动的免疫学社区。我们的博士前培训计划结合了独特的元素，将丰富研究生的经验，为受训人员提供支持。这些措施包括每年参加特定的国家会议的机会，由我们的培训教师组成的委员会对受训人员的科学报告和进展进行正式评估，以及与选定的免疫学研讨会演讲者进行专门互动。一个外部咨询委员会将对该计划进行持续评估。在NIH T32连续25年支持的基础上，该应用程序重新聚焦我们的培训计划，以利用我们部门在天然免疫和适应性免疫方面的研究优势，重点放在过敏、自身免疫和传染病上。

DESCRIPTION (provided by applicant): In this application, we request support for six students each year in our pre-doctoral training program in the Department of Immunology at the University of Washington, with Dr. Pamela Fink as Program Director, and Dr. Michael Bevan as Co-Director. This new application reflects the long history of our department, dating back to its inception in 1989, with founding members derived from backgrounds in biochemistry, molecular biology, infectious disease research, and basic immunology. Our department faculty has grown to include specialists in basic research as well as clinicians who study and treat human infectious diseases, autoimmunity, and immunodeficiencies. Our training program combines didactic coursework with student-led discussion groups and rigorous qualifying and general exams, with the goal of developing the next generation of scientists who think, write, and speak clearly about the key scientific questions and how to solve them. Our students are recruited from our own Immunology graduate program, from the UW Molecular and Cellular Biology graduate program, and from the Medical Scientist Training Program. These students benefit from the rich, diverse, and interactive Immunology community at UW and its affiliated institutions. Our pre-doctoral training program incorporates unique elements that will enrich the graduate student experience for supported trainees. These include opportunities to attend specific national meetings annually, formal evaluation of trainees' scientific presentations and progress by a committee composed of members of our training faculty, and dedicated interactions with selected Immunology seminar speakers. An External Advisory Committee will provide ongoing evaluation of the program. Building on 25 consecutive years of NIH T32 support, this application refocuses our training program to draw on the strengths of our departmental research at the interface of innate and adaptive immunity, with an emphasis on allergy, autoimmunity, and infectious disease.