Hydrogels for hMSC delivery & engraftment

用于 hMSC 递送的水凝胶

基本信息

  • 批准号:
    8900758
  • 负责人:
  • 金额:
    $ 30.29万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2012
  • 资助国家:
    美国
  • 起止时间:
    2012-08-01 至 2016-07-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Mesenchymal stem cells (MSC) represent a promising cell source for regenerative medicine applications. Transplanted MSC enhance bone, cartilage, and intervertebral disc repair in pre-clinical models and initial clinical trials. Howevr, the engraftment of transplanted MSC is extremely low, and the beneficial effects are generally attributed to trophic/paracrine actions. The low engraftment and survival of transplanted MSC significantly limit these cell-based therapies in the repair of challenging, non-healing defects. A major hurdle to MSC survival and engraftment is the lack of appropriate bioactive delivery vehicles. The objective of this project is to engineer biofunctional hydrogels to direct human MSC (hMSC) survival, engraftment, and function. Our central hypothesis is that hydrogels presenting integrin-specific adhesive ligands will promote hMSC engraftment, osteogenesis, and bone repair. This work will establish bioactive cell delivery vehicles that enhance MSC survival, engraftment and function compared to existing synthetic matrices. Aim 1: Engineer hydrogels presenting integrin-specific adhesive ligands to direct hMSC fate commitment and differentiation. Aim 2: Evaluate the ability of integrin-specific hydrogels to promote hMSC survival, engraftment, and bone repair. Aim 3: Analyze the effects of VEGF co-delivery from hydrogels on hMSC engraftment and bone repair. The proposed research is innovative because it focuses on exploiting integrin binding specificity to control hMSC survival, engraftment and function for bone repair and integrates new in vivo imaging approaches. This work is expected to yield the following outcomes. First, we will determine the extent to which integrin-specific ligands regulate hMSC signaling, commitment and differentiation into osteogenic, adipogenic and chondrogenic lineages. We will also establish novel bioactive cell delivery vehicles that enhance MSC survival, engraftment and bone formation for improved bone repair. Finally, because of the transformative potential of MSC, this research will have broad significance and impact to many regenerative medicine applications.
描述(由申请人提供):间充质干细胞(MSC)是再生医学应用中很有前途的细胞来源。移植的间充质干细胞在临床前模型和初步临床试验中增强骨、软骨和椎间盘修复。然而,移植的间充质干细胞的植入极低,其有益作用通常归因于营养/旁分泌作用。移植间充质干细胞的低植入率和存活率极大地限制了这些基于细胞的治疗方法在修复具有挑战性的、不可愈合的缺陷方面的应用。一个

项目成果

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Andres J Garcia其他文献

Andres J Garcia的其他文献

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{{ truncateString('Andres J Garcia', 18)}}的其他基金

Hydrogels for human beta cell survival, function and evasion of immune rejection
用于人类β细胞存活、功能和逃避免疫排斥的水凝胶
  • 批准号:
    10512947
  • 财政年份:
    2022
  • 资助金额:
    $ 30.29万
  • 项目类别:
Hydrogels for human beta cell survival, function and evasion of immune rejection
用于人类β细胞存活、功能和逃避免疫排斥的水凝胶
  • 批准号:
    10705265
  • 财政年份:
    2022
  • 资助金额:
    $ 30.29万
  • 项目类别:
Hydrogels for human beta cell survival, function and evasion of immune rejection
用于人类β细胞存活、功能和逃避免疫排斥的水凝胶
  • 批准号:
    10865870
  • 财政年份:
    2022
  • 资助金额:
    $ 30.29万
  • 项目类别:
BIOMATERIALS FOR STEM CELL DERIVED BETA CELL TRANSPLANTATION
用于干细胞衍生的 β 细胞移植的生物材料
  • 批准号:
    10517827
  • 财政年份:
    2021
  • 资助金额:
    $ 30.29万
  • 项目类别:
BIOMATERIALS FOR STEM CELL-DERIVED BETA CELL TRANSPLANTATION
用于干细胞衍生的 β 细胞移植的生物材料
  • 批准号:
    10684716
  • 财政年份:
    2021
  • 资助金额:
    $ 30.29万
  • 项目类别:
BIOMATERIALS FOR STEM CELL-DERIVED BETA CELL TRANSPLANTATION
用于干细胞衍生的 β 细胞移植的生物材料
  • 批准号:
    10306891
  • 财政年份:
    2021
  • 资助金额:
    $ 30.29万
  • 项目类别:
BIOMATERIALS FOR STEM CELL-DERIVED BETA CELL TRANSPLANTATION
用于干细胞衍生的 β 细胞移植的生物材料
  • 批准号:
    10557968
  • 财政年份:
    2021
  • 资助金额:
    $ 30.29万
  • 项目类别:
BIOMATERIALS FOR STEM CELL-DERIVED BETA CELL TRANSPLANTATION
用于干细胞衍生的 β 细胞移植的生物材料
  • 批准号:
    10905940
  • 财政年份:
    2021
  • 资助金额:
    $ 30.29万
  • 项目类别:
Targeted delivery of immunomodulatory biologics for induction of immune privilege to allogeneic pancreatic islet grafts
靶向递送免疫调节生物制剂以诱导同种异体胰岛移植物的免疫特权
  • 批准号:
    10227259
  • 财政年份:
    2020
  • 资助金额:
    $ 30.29万
  • 项目类别:
Hydrogels for delivery of muscle stem cells to diaphragm
用于将肌肉干细胞递送至隔膜的水凝胶
  • 批准号:
    10281444
  • 财政年份:
    2020
  • 资助金额:
    $ 30.29万
  • 项目类别:

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