权益分类	功能权益	普通用户	{{item.name}}会员
{{category.name}}	{{benefitItem.name}}

Neural Nature of Persecutory Ideation in Schizophrenia

精神分裂症迫害意念的神经本质

基本信息

批准号：
8787690
负责人：
Krista Michelle Wisner
金额：
$ 3.69万
依托单位：
UNIVERSITY OF MINNESOTA
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-01-09 至 2016-12-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8787690
关键词：
Address Affect Age Architecture Behavior Belief Biological Biological Markers Brain Brain region CCL4 gene Chronic Chronic Schizophrenia Cognitive deficits Communities Complex Corpus striatum structure Data Data Set Decision Making Delusions Disease Distress Economics Equilibrium Etiology Functional Magnetic Resonance Imaging Functional disorder Future Goals Hallucinations Impairment Individual Individual Differences Institution Investigation Lead Life Link Magnetic Resonance Minnesota Monozygotic Twinning Monozygotic twins Nature Neurobiology Parietal Participant Patient Self-Report Patients Pattern Personality Traits Play Predisposition Prisoner&apos s Dilemma Procedures Psychotic Disorders Research Research Design Research Personnel Resistance Rest Risk Sampling Schizophrenia Sensory Severities Severity of illness Social isolation Specificity Stimulus Structure Symptoms System Testing Time Trust Twin Multiple Birth Validation Variant Violence Work brain behavior economic value experience first episode schizophrenia follow-up ideation neuropsychiatry novel programs public health relevance relating to nervous system response sex social cognition theories therapy development trait

项目摘要

DESCRIPTION (provided by applicant): Persecutory ideation occurs across multiple neuropsychiatric disorders; it can be resistant to treatment, and is associated with prominent negative affect as well as an increased risk of violent acts. The biological substrates currently remain unclear although two main systems have been proposed as the underlying neurobiology: frontal-striatal regions, and separately, temporo-parietal regions. Recent theories of brain functioning suggest rather than isolated regions or systems, complex behaviors may be better represented by a combination of local and global connections between distinct brain regions. Therefore, a thorough examination of how large- scale neural connectivity is associated with delusional ideation is warranted to increase understanding of the etiology. Using the Minnesota Trust Game, a novel variant of the Prisoner's Dilemma Game, the project will employ a functional connectivity approach to assess both the intra- and inter-network connectivity contributions to the neural architecture involved in suspiciousness. Analyses will target connectivity metrics associated with the theorized frontal-striatal and temporo-parietal regions to evaluate the degree to which these systems are engaged during the task, and the capacity for derived metrics to predict individual differences in persecutory ideation. The first primary goal i to develop a theory driven biomarker of suspiciousness by investigating functional magnetic resonance data from a sample of schizophrenia patients and a sample of community dwelling monozygotic twins who played the Minnesota Trust Game while in the scanner. This includes assessment of the external validation of the biomarker by examining associations with individual differences in persecutory ideation, or alienation which is an approximation of psychosis-like experiences in community participants. It also includes investigating whether discordance in connectivity metrics predicts discordance in personality traits in twins. The second primary goal is to test generalizability of the biomarker by evaluating the capacity of corresponding connectivity metrics, derived from resting-state, to predict similar relationships with individual differences in persecutory ideation in a separate sample of schizophrenia patients and controls. Follow-up analyses will evaluate the specificity of these associations. Furthermore, the capacity of the networks to distinguish patients from controls, and moreover, first-episode from chronic patients will also be investigated. Through this work procedures may identify connectivity hubs which appear to be critical for the experience of persecutory ideation, and thus could be employed as targets for future treatments and biomarkers to identify those at risk for these distressing beliefs.

描述（由申请人提供）：迫害意念发生在多种神经精神疾病中；它可能对治疗产生抵抗力，并与显着的负面影响以及暴力行为的风险增加有关。尽管已提出两个主要系统作为潜在的神经生物学，但其生物底物目前仍不清楚：额叶纹状体区域和颞顶叶区域。最近的大脑功能理论表明，复杂的行为可能不是孤立的区域或系统，而是通过不同大脑区域之间的局部和全局连接的组合来更好地表示。因此，有必要彻底检查大规模神经连接如何与妄想观念相关，以增进对其病因的理解。该项目将使用明尼苏达信任游戏（囚徒困境游戏的一种新变体），采用功能连接方法来评估网络内和网络间连接对涉及可疑性的神经架构的贡献。分析将针对与理论化的额叶纹状体和颞顶叶区域相关的连接指标评估这些系统在任务过程中的参与程度，以及派生指标预测迫害意念个体差异的能力。第一个主要目标是通过研究来自精神分裂症患者样本和在扫描仪中玩明尼苏达信任游戏的社区居住同卵双胞胎样本的功能磁共振数据来开发一种理论驱动的可疑性生物标记。这包括通过检查与迫害观念或疏离感（类似于社区参与者的精神病样经历）的个体差异之间的关联来评估生物标志物的外部验证。它还包括调查连通性指标的不一致是否预示着双胞胎性格特征的不一致。第二个主要目标是通过评估源自静息状态的相应连接指标的能力来测试生物标志物的普遍性，以预测精神分裂症患者和对照的单独样本中迫害意念个体差异的相似关系。后续分析将评估这些关联的特异性。此外，还将研究网络区分患者与对照组以及首次发作与慢性患者的能力。通过这项工作程序，可以识别出对遭受迫害意念的经历至关重要的连接中心，因此可以用作未来治疗的目标和生物标志物，以识别那些面临这些令人痛苦的信念的风险的人。