4.7T Magnet System Upgrade

4.7T磁体系统升级

• 批准号: 8640483
• 负责人: JEAN A KING
• 金额: $ 59.8万
• 依托单位: UNIV OF MASSACHUSETTS MED SCH WORCESTER
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-15 至 2016-04-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8640483
• 关键词: Animals; Applications Grants; Area; Brain Diseases; Commit; Communities; Data; Data Quality; Diffusion Magnetic Resonance Imaging; Disease; Functional Magnetic Resonance Imaging; Funding; Goals; Grant; Human; Image; Imaging Techniques; Institutes; Intervention; Leadership; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Massachusetts; Microbiology; Molecular; Molecular Medicine; Mus; National Institute of Drug Abuse; National Institute of General Medical Sciences; National Institute of Mental Health; National Institute of Neurological Disorders and Stroke; National Institute on Alcohol Abuse and Alcoholism; Neurology; Physiological; Process; Psychiatry; Research; Research Personnel; Resolution; Resources; Science; Site; System; Technology; Training; Translating; Translational Research; United States National Institutes of Health; Universities; analog; awake; comparative; insight; instrument; instrumentation; medical schools; member; neuroimaging; novel; preclinical study; prevent; research study; success

DESCRIPTION (provided by applicant): The purpose of this shared S10 instrumentation grant application is to upgrade the Bruker 4.7T high-field magnetic resonance (MR) spectrometer to be shared by a group of NIH funded investigators and others at the University of Massachusetts Medical School (UMMS). The Center for Comparative NeuroImaging (CCNI) at UMMS was established in 2001 as a Center of Excellence in comparative neuroimaging to promote translational research focused on the understanding and treatment of disease processes with particular emphasis on brain disorders. The CCNI has been the site of many novel discoveries in the last 10 years, including technologies for performing awake animal imaging. However, the severely out dated configuration and instability of the current analogue components tremendously hinders the advancement of multiple NIH- supported research studies due to the severe limitations and challenges encountered when attempting to conduct MR spectroscopy (MRS), diffusion tensor imaging (DTI), parallel imaging and mouse imaging studies at the CCNI. The upgrade of the 4.7T system will fill a critical need to perform MRI experiments by utilizing a stable and reliable resource. The upgrade will also enhance the current capabilities of the over a decade-old spectrometer and significantly increase multi-modal imaging studies. Specifically: (1) The upgrade will significantly enhance the data quality of functional magnetic resonance imaging (fMRI), functional connectivity, mice imaging and MRS. (2) The upgrade will make it possible to conduct studies using DTI and parallel imaging. (3) The upgrade will immediately double the number of users from five to ten. The aims of this proposal are 1) to provide current NIH-funded investigators with access to a state-of-the-art high-field (MR) instrument to significantly enhance anatomical, functional and spectral resolution for MRI and MRS applications; 2) to continue to educate and train NIH-funded investigators in the use of imaging techniques pertaining to their specific research areas; 3) to promote the use of novel imaging techniques in under-explored research areas; 4) to provide access to a new state of the art 4.7T system for potential NIH funded researchers and new hires to collect pilot data for grant submission; 5) to increase opportunities for multi-modal cutting edge research, and 6) to build an academic community focused on the utilization of high- field imaging in biomedical sciences. The major User Groups (identified in this proposal) are supported by grants from several NIH institutes (including NIMH, NIDA, NIAAA, NINDS, and NIGMS). The users include members of the Departments of Psychiatry, Neurology, Microbiology and Physiological Systems and Molecular Medicine. The leadership at UMMS is committed to providing important additional resources to enhance the success of the upgrade, including support for a dedicated MR technician. The overreaching goal for research on the upgraded 4.7T system is to ultimately translate the cellular and molecular insights gained from these pre-clinical studies into interventions that will both cure and prevent human disorders.

描述(申请人提供)：这项共享的S10仪器拨款申请的目的是升级Bruker 4.7T高场磁共振(MR)光谱仪，由NIH资助的一组研究人员和马萨诸塞大学医学院(UMMS)的其他人共享。密歇根大学比较神经成像中心(CCNI)成立于2001年，是比较神经成像领域的卓越中心，旨在促进专注于疾病过程的理解和治疗的转化性研究，特别是大脑疾病。在过去的10年里，CCNI一直是许多新发现的地点，包括执行清醒动物成像的技术。然而，由于在CCNI进行磁共振波谱(MRS)、扩散张量成像(DTI)、平行成像和小鼠成像研究时遇到的严重限制和挑战，当前模拟组件的严重过时的配置和不稳定极大地阻碍了NIH支持的多项研究的进展。4.7T系统的升级将满足利用稳定可靠的资源进行磁共振实验的迫切需求。此次升级还将增强已有十多年历史的光谱仪的现有能力，并显著增加多模式成像研究。具体地说：(1)升级将显著提高功能磁共振成像(FMRI)、功能连接、小鼠成像和MRS的数据质量。(2)升级将使使用DTI和并行成像进行研究成为可能。(3)升级将使用户数量立即翻一番，从5个增加到10个。这项建议的目的是：1)为目前由美国国立卫生研究院资助的研究人员提供使用最先进的高场(MR)仪器的机会，以显著提高MRI和MRS应用的解剖、功能和光谱分辨率；2)继续教育和培训NIH资助的研究人员使用与其特定研究领域有关的成像技术；3)促进在探索不足的研究领域使用新的成像技术；4)为潜在的NIH资助的研究人员和新雇员提供使用最先进的4.7T系统的途径，以收集用于拨款提交的试点数据；5)增加多模式前沿研究的机会，6)建立以高场成像在生物医学科学中的应用为重点的学术社区。本提案中确定的主要用户群体得到了几个NIH研究所(包括NIMH、NIDA、NIAAA、NINDS和NIGMS)的赠款支持。用户包括精神病学、神经病学、微生物学、生理系统和分子医学系的成员。UMMS的领导层致力于提供重要的额外资源，以提高升级的成功，包括支持一名专职的MR技术人员。升级后的4.7T系统研究的超常目标是最终将从这些临床前研究中获得的细胞和分子洞察力转化为既能治愈又能预防人类疾病的干预措施。

项目成果

Traffic-related particulate matter affects behavior, inflammation, and neural integrity in a developmental rodent model.

• DOI: 10.1016/j.envres.2020.109242
• 发表时间: 2020-02
• 期刊: Environmental research
• 影响因子: 8.3
• 作者: B. Nephew;A. Németh;N. Hudda;G. Beamer;P. Mann;J. Petitto;R. Cali;M. Febo;P. Kulkarni;G. Poirier;J. King;J. Durant;D. Brugge

Early life social stress and resting state functional connectivity in postpartum rat anterior cingulate circuits.

• DOI: 10.1016/j.jad.2017.12.089
• 发表时间: 2018-03-15
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Nephew BC;Febo M;Huang W;Colon-Perez LM;Payne L;Poirier GL;Greene O;King JA
• 通讯作者: King JA

Robustness of sex-differences in functional connectivity over time in middle-aged marmosets.

• DOI: 10.1038/s41598-020-73811-9
• 发表时间: 2020-10-06
• 期刊: Scientific reports
• 影响因子: 4.6
• 作者: Nephew BC;Febo M;Cali R;Workman KP;Payne L;Moore CM;King JA;Lacreuse A
• 通讯作者: Lacreuse A

Evidence of Altered Brain Responses to Nicotine in an Animal Model of Attention Deficit/Hyperactivity Disorder.

注意力缺陷/多动症动物模型中大脑对尼古丁反应改变的证据。

• DOI: 10.1093/ntr/ntx088
• 发表时间: 2017
• 期刊: Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco
• 作者: Poirier,GuillaumeL;Huang,Wei;Tam,Kelly;DiFranza,JosephR;King,JeanA
• 通讯作者: King,JeanA