甲基苯丙胺使用和艾滋病毒疾病中血脑屏障损伤的生物标志物-猫眼课题宝

甲基苯丙胺使用和艾滋病毒疾病中血脑屏障损伤的生物标志物

批准号：

8730973

负责人：

Jennifer E Iudicello

金额：

$16.84万

依托单位：

UNIVERSITY OF CALIFORNIA, SAN DIEGO

依托单位国家：

美国

项目类别：

财政年份：

2014

资助国家：

美国

项目状态：

已结题

起止时间：

2014-04-01 至 2019-03-31

来源：

https://reporter.nih.gov/project-details/8730973

关键词：

AIDS neuropathy Acquired Immunodeficiency Syndrome Affect Area Basement membrane Biological Biological Markers Blood Blood - brain barrier anatomy Brain Cell Adhesion Molecules Clinical Clinical Research Collaborations Communicable Diseases Data Collection Development Diagnosis Disease Endothelial Cells Fostering Foundations Functional disorder Future Goals Grant HIV Health Immune system Impairment Individual Influentials Injury Investigation Knowledge Laboratories Lead Life Link Measures Mediating Membrane Proteins Mentored Patient-Oriented Research Career Development Award Mentors Methamphetamine Methamphetamine dependence Monitor Nervous System Trauma Neurobiology Neurocognitive Neuronal Injury Neuropsychology Neurosciences Outcome Pathogenesis Persons Prevalence Process Proteins Public Health Reporting Research Research Infrastructure Research Methodology Research Personnel Research Training Resources Risk Factors Role Science Serum Albumin Services Stem cells Structure Substance abuse problem Tight Junctions Training Universities Vascular Diseases Vascular System Virus Work addiction analytical method antiretroviral therapy assay development base career central nervous system injury drug development effective therapy experience functional decline functional disability functional outcomes immune activation improved innovation insight multidisciplinary neurobehavioral neuropsychological outcome forecast patient oriented patient oriented research programs public health relevance research study skills statistics tool

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中文摘要

翻译

描述：Jennifer Iudicello博士申请K23的目的是在甲基苯丙胺(冰毒)成瘾和艾滋病毒疾病的神经生物学方面提供重点培训和指导，建立在她在成瘾和神经艾滋病的神经认知和功能后果方面的坚实学术基础上，以服务于她作为一名独立的、以患者为导向的跨学科研究人员的长期目标。拟议的培训、知识和研究经验将促进她发展成为一名独立的调查员，能够将实验室神经生物学发现与其临床表现和对冰毒成瘾和艾滋病毒疾病患者的现实影响联系起来。这项工作意义重大

英文摘要

DESCRIPTION: The purpose of Dr. Jennifer Iudicello's K23 application is to provide focused training and mentoring in the neurobiological aspects of methamphetamine (METH) addiction and HIV disease that builds on her strong academic foundation in the neurocognitive and functional consequences of addictions and neuroAIDS in service of her long-term goals as an independent, transdisciplinary patient-oriented investigator. The proposed training, knowledge, and research experience will promote her development into an independent investigator capable of bridging laboratory neurobiological discoveries with their clinical expression and real-world impact among persons living with METH addiction and HIV disease. This work is of considerable

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