Biomarkers of Blood Brain Barrier Injury in Methamphetamine Use and HIV Disease

甲基苯丙胺使用和艾滋病毒疾病中血脑屏障损伤的生物标志物

• 批准号: 8730973
• 负责人: Jennifer E Iudicello
• 金额: $ 16.84万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8730973
• 关键词: AIDS neuropathy; Acquired Immunodeficiency Syndrome; Affect; Area; Basement membrane; Biological; Biological Markers; Blood; Blood - brain barrier anatomy; Brain; Cell Adhesion Molecules; Clinical; Clinical Research; Collaborations; Communicable Diseases; Data Collection; Development; Diagnosis; Disease; Endothelial Cells; Fostering; Foundations; Functional disorder; Future; Goals; Grant; HIV; Health; Immune system; Impairment; Individual; Influentials; Injury; Investigation; Knowledge; Laboratories; Lead; Life; Link; Measures; Mediating; Membrane Proteins; Mentored Patient-Oriented Research Career Development Award; Mentors; Methamphetamine; Methamphetamine dependence; Monitor; Nervous System Trauma; Neurobiology; Neurocognitive; Neuronal Injury; Neuropsychology; Neurosciences; Outcome; Pathogenesis; Persons; Prevalence; Process; Proteins; Public Health; Reporting; Research; Research Infrastructure; Research Methodology; Research Personnel; Research Training; Resources; Risk Factors; Role; Science; Serum Albumin; Services; Stem cells; Structure; Substance abuse problem; Tight Junctions; Training; Universities; Vascular Diseases; Vascular System; Virus; Work; addiction; analytical method; antiretroviral therapy; assay development; base; career; central nervous system injury; drug development; effective therapy; experience; functional decline; functional disability; functional outcomes; immune activation; improved; innovation; insight; multidisciplinary; neurobehavioral; neuropsychological; outcome forecast; patient oriented; patient oriented research; programs; public health relevance; research study; skills; statistics; tool

DESCRIPTION: The purpose of Dr. Jennifer Iudicello's K23 application is to provide focused training and mentoring in the neurobiological aspects of methamphetamine (METH) addiction and HIV disease that builds on her strong academic foundation in the neurocognitive and functional consequences of addictions and neuroAIDS in service of her long-term goals as an independent, transdisciplinary patient-oriented investigator. The proposed training, knowledge, and research experience will promote her development into an independent investigator capable of bridging laboratory neurobiological discoveries with their clinical expression and real-world impact among persons living with METH addiction and HIV disease. This work is of considerable

产品说明：Jennifer Iudicello博士的K23应用程序的目的是在甲基苯丙胺（METH）成瘾和艾滋病的神经生物学方面提供重点培训和指导，这建立在她在成瘾和神经艾滋病的神经认知和功能后果方面的强大学术基础上，以服务于她作为独立，跨学科的长期目标。拟议的培训，知识和研究经验将促进她发展成为一个独立的研究者，能够将实验室神经生物学发现与METH成瘾和艾滋病患者的临床表现和现实世界的影响联系起来。这项工作是相当大的