Neurobehavioral & Psychiatry Core

神经行为

• 批准号: 10561652
• 负责人: Jennifer E Iudicello
• 金额: $ 16.72万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-24 至 2026-01-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10561652
• 关键词: AIDS clinical trial group; AIDS prevention; Acquired Immunodeficiency Syndrome; Address; Anhedonia; Anti-Retroviral Agents; Anxiety; Anxiety Disorders; Area; Authorization documentation; Basic Science; Biological; Biological Factors; Biological Markers; COVID-19 pandemic; Certification; Clinical; Clinical Research; Clinical Trials; Clinical assessments; Cognition; Cognitive; Collaborations; Complex; Consult; Consultations; Cytomegalovirus; Data; Depressed mood; Development; Diagnostic; Dimensions; Disease; Disparity; Doctor of Philosophy; Educational workshop; Evaluation; Extramural Activities; Fright; Funding; Goals; HIV; HIV Seronegativity; Health; Impairment; Individual; Inflammatory; Interdisciplinary Study; Interleukin-6; International; Intervention; Investigation; Leadership; Life; Link; Loneliness; Major Depressive Disorder; Maps; Medical; Mental Depression; Mental Health; Mental disorders; Mentors; Metabolic syndrome; Methods; Mood Disorders; Moods; Neurocognition; Neurocognitive; Neurocognitive Deficit; Neurologic; Neuropsychology; Outcome; Participant; Pathogenesis; Persons; Phenotype; Pilot Projects; Process; Psychiatric Diagnosis; Psychiatrist; Psychiatry; Psychological Factors; Psychosocial Factor; Registries; Reproducibility; Research; Research Design; Research Personnel; Research Priority; Resources; Risk; Role; Science; Self Efficacy; Services; Social support; Standardization; Stress; Symptoms; Telephone; Time; Training; Translational Research; Trauma; Underserved Population; Validation; Vinorelbine tartrate; Viral Load result; Visit; Work; adverse childhood events; authority; career development; clinically relevant; co-infection; comorbidity; daily functioning; data standards; depressive symptoms; follow-up; gut-brain axis; health disparity; immune depression; instrument; low socioeconomic status; meetings; metabolome; microbiome; multidisciplinary; neuroAIDS; neurobehavioral; neuroinflammation; neurotoxic; outreach; psychiatric symptom; recruit; remote assessment; resilience; social stigma; standardize measure; substance use; translational study

PROJECT SUMMARY/ABSTRACT: NEUROBEHAVIORAL AND PSYCHIATRY CORE The NeuroBehavioral and Psychiatry (NBP) Core, previously the Neurobehavioral Unit of the NeuroAssessment Core from the prior funding period, is a new Core proposed for the competing HNRC renewal. The new NBP Core will apply assessment expertise in conducting comprehensive neuropsychological, psychiatric (including both psychiatric diagnoses and dimensional symptom levels), substance use, and daily functioning assessments. This supports the Center’s new emphasis on neurobehavioral phenotypes among persons with HIV (PWH), and links them to medical and biological data from other HNRC Cores and associated studies. NBP aims map directly onto the Office of AIDS Research Priorities under the major topic of “HIV- associated comorbidities, coinfections, and complications” by addressing areas of neurologic consequences, mental illness, and health disparities. The goals of the NBP Core are to contribute to the identification of individuals who have evidenced changes in cognition, depression and daily functioning, and to provide comprehensive longitudinal neurocognitive, psychiatric, substance use and everyday functioning assessments on the PWH and HIV- comparison participants. Importantly, our core will provide the neuropsychological and psychiatric (including depression) assessments in order to determine neurobehavioral phenotypes. We aim to facilitate and enhance multidisciplinary research in neuroHIV by providing a range of services, training and scientific consultation to projects such as investigator-driven R01s, R21s, and R34s, international neuroHIV studies, and a variety of intra- and extramural investigations. Historically, the NBP Core and its investigators have been national and international leaders in the neuroHIV field, spurring the development of both international harmonization of assessments and new methods, while adapting to the continually evolving scientific landscape. We aim to continue in this regard. In addition, in support of the HNRC’s increased focus on combined neurobehavioral phenotypes among PWH, and participants who change over time, the NBP Core will administer a more detailed psychiatric assessment which will examine detailed components of depression (e.g., anhedonia, apathy), anxiety, stress, adverse childhood events and life trauma, and resilience and social support. All of these factors may influence the complex relationships among neurocognition, depression, HIV disease and other clinical outcomes. We will work hand-in-hand with 1) the NeuroMedical Core to identify underlying biological mechanisms of neurobehavioral phenotypes, exploring connections to HIV disease (e.g., CSF viral load), inflammatory processes/biomarkers (e.g., IL-6), other medical comorbidities (e.g., metabolic syndrome), co- infections (e.g., CMV; NM and NVB Cores); and 2) with the MIBI Core to explore effects of microbiome and metabolome on neurobehavioral outcomes and/or phenotypes; and with both NM and NVB Cores regarding neuroinflammation and long-term protective and/or neurotoxic effects of antiretrovirals.

项目摘要/摘要：神经行为和精神病学核心 神经行为和精神病学(NBP)核心，以前是 神经评估核心来自前一个资助期，是为竞争对手的HNRC更新而提议的新核心。 新的NBP核心将应用评估专业知识进行全面的神经心理学， 精神病学(包括精神病学诊断和次元症状水平)、物质使用和日常生活 功能性评估。这支持了该中心对以下人群神经行为表型的新强调 艾滋病毒携带者(PWH)，并将他们链接到来自其他HNRC核心和相关的医疗和生物数据 学习。NBP的目标是直接映射到艾滋病研究优先事项办公室的“艾滋病毒-- 相关的合并症、合并感染和并发症“通过解决神经系统后果领域， 精神疾病和健康差距。NBP核心的目标是帮助确定 有证据表明认知、抑郁和日常功能发生变化的个人，并提供 全面的纵向神经认知、精神、物质使用和日常功能评估 关于威尔斯亲王医院和艾滋病毒--比较参与者。重要的是，我们的核心将提供神经心理学和 精神(包括抑郁)评估，以确定神经行为表型。我们的目标是 通过提供一系列服务、培训和培训，促进和加强神经艾滋病毒的多学科研究 为研究人员驱动的R01、R21和R34、国际神经艾滋病毒等项目提供科学咨询 研究，以及各种内部和外部调查。从历史上看，NBP核心及其调查人员 一直是神经艾滋病毒领域的国内和国际领导者，推动了国际 统一评估和新方法，同时适应不断发展的科学格局。 我们的目标是在这方面继续下去。此外，为了支持HNRC更加关注联合 在PWH和随时间改变的参与者中的神经行为表型，NBP核心将管理 更详细的精神评估，它将检查抑郁症的详细组成部分(例如，快感缺乏， 焦虑、压力、童年不良事件和生活创伤，以及复原力和社会支持。所有这些都是 可能影响神经认知、抑郁、HIV疾病等之间的复杂关系的因素 临床结果。我们将与神经医学核心携手合作，以确定潜在的生物学 神经行为表型的机制，探索与艾滋病毒疾病的联系(例如，脑脊液病毒载量)， 炎症过程/生物标志物(例如，IL-6)、其他医学并存(例如，代谢综合征)、 感染(例如，CMV；NM和NVB核心)；以及2)与MIBI核心一起探索微生物组和 代谢组对神经行为结果和/或表型的影响；并以NM和NVB为核心 神经炎症和抗逆转录病毒药物的长期保护和/或神经毒性作用。