Research Program: Cancer Epidemiology, Prevention and Control

描述和布局摘要 癌症流行病学、预防和控制(CEPC)计划旨在降低癌症发病率和 通过研究癌症的环境和遗传原因、及早发现、降低风险和 改善结果和生活质量。为了完成这一使命，我们庞大的、多学科的教职员工 在一般人群中进行临床和基于社区的研究，以及在有针对性的和经常 服务不足的人群。 CEPC计划目前有来自14个部门的76名成员和所有三个联盟成员 代表多个科学学科的机构，包括流行病学、遗传学、社会学、心理学、 内科学、内科肿瘤学、通信学、营养学、生物统计学和卫生经济学。三十岁- 9名CEPC教职员工在FHCRC担任主要职务，36名在威斯康星州大学担任主要职务，1名 总部设在西雅图儿童中心。CEPC的教职员工已经成功地获得了独立的资金来支持 他们的研究：93%拥有同行评议的癌症相关研究拨款或合同，正在进行临床试验， 或者是新招聘的调查人员，导致研究投资组合(直接)总额为25,984,344美元 赠款/合同资金，其中21,616,050美元来自同行审查，12,793,467美元来自NCI。在.期间 在之前的资助期间，CEPC项目教职员工共发表了1655篇论文，其中25%是INTERNAL-INTERNAL 方案方面，32%是方案间的，17%是机构间的。重要的节目资源 包括：普吉特湾流行病学和最终结果监测(SEER)癌症登记，分子 流行病学和生物标记物实验室，维护良好的大型队列，如妇女健康 倡议(WHI)、临床试验小组，包括国家协调中心、广泛的数据和生物制品 存储库、预防中心共享资源、计算基础设施和领导力，以及 在分析和解释基因组数据方面获得国家认可的专业知识。CEPC计划 继续在培训下一代癌症研究人员/人群方面发挥重要作用 科学家。

Description and Lay Summary The Cancer Epidemiology, Prevention and Control (CEPC) Program seeks to reduce cancer incidence and mortality through research on environmental and genetic causes of cancer, early detection, risk reduction, and improved outcomes and quality of life. To accomplish this mission, our large, multi-disciplinary faculty conducts clinical and community-based studies in the general population, as well as in targeted and often underserved populations. The CEPC Program currently has 76 members from 14 departments and all three Consortium member institutions, representing multiple scientific disciplines, including epidemiology, genetics, sociology, psychology, internal medicine, medical oncology, communications, nutrition, biostatistics, and health economics. Thirty- nine CEPC faculty have primary appointments at FHCRC, 36 have primary appointments at UW, and one is based at Seattle Children's. CEPC faculty have been successful in obtaining independent funding to support their research: 93% have peer-reviewed cancer related research grants or contracts, are PI on a clinical trial, or are newly recruited investigators, resulting in a research portfolio (direct) totaling $25,984,344 in grants/contract funding, of which $21,616,050 is peer reviewed and $12,793,467 is from NCI. During the previous grant period, CEPC Program faculty published a total of 1655 papers, 25% of which were intra- programmatic, 32% were inter-programmatic, and 17% were inter-institutional. Important program resources include: the Puget Sound Surveillance Epidemiology and End Results (SEER) Cancer Registry, the Molecular Epidemiology and Biomarker Laboratories, large well-maintained cohorts such as the Women's Health Initiative (WHI), clinical trial groups including national coordinating centers, extensive data and biospecimen repositories, the Prevention Center Shared Resource, computational infrastructure and leadership, and nationally-recognized expertise with analysis and interpretation of genomic data. The CEPC Program continues to play an important role in the training of the next generation of cancer research/population scientists.