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Cortisol regulation during exercise and obesity in adolescents with Down syndrome

患有唐氏综合症的青少年运动和肥胖期间的皮质醇调节

基本信息

批准号：
9111677
负责人：
Edward Andrew Pitchford
金额：
$ 3.36万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-09-01 至 2016-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9111677
关键词：
Abdomen Address Adolescent Adult Aerobic Age Award Body Composition Body Weight Body mass index Child Childhood Circadian Rhythms Data Development Diet Down Syndrome Endocrinology Energy Metabolism Environment Exercise Exercise Physiology Exhibits Fatty acid glycerol esters Fellowship Foundations Functional disorder Future Gender General Population Glucocorticoids Goals Growth Health Health behavior High Prevalence Hormonal Hydrocortisone Individual Intervention Life Living Wills Matched Group Measurement Measures Mediating Metabolic Neurosecretory Systems Obesity Overweight Persons Physical activity Physiological Population Populations at Risk Prevalence Prevention program Public Health Regulation Research Research Personnel Research Project Grants Research Training Resources Rest Saliva Sampling Source Stress Testing Time Training Treadmill Tests United States Weight Gain Work Youth abdominal fat career design disability effective intervention fitness health disparity hypothalamic-pituitary-adrenal axis improved innovation insight interest novel obesity in children obesity risk peer pre-doctoral prevent protective effect public health relevance response skills tool young adult

项目摘要

DESCRIPTION (provided by applicant): The prevalence of overweight and obesity among adolescents with Down syndrome exceeds 50% and is significantly greater than rates observed in the general population. This condition persists into adulthood and contributes to the development of additional secondary health conditions. Thus, obesity represents a predominant source of health disparity. It remains unclear what causes the higher prevalence of obesity among adolescents with Down syndrome. Glucocorticoid (i.e. cortisol) function may be a novel neuroendocrine mechanism to explain the increased risk of obesity in this population. Recent research suggests that young adults with Down syndrome exhibit cortisol dysregulation compared to adults without disabilities. Dysregulation of the hypothalamic-pituitary-adrenal (HPA) axis and cortisol function have been shown to promote weight gain and greater abdominal fat mass in the general population. However, it remains unclear whether differences in cortisol functioning in adolescents with Down syndrome contribute to the greater prevalence of obesity. Furthermore, many interventions to address pediatric obesity involve exercise. Normal cortisol response to exercise is expected to have a protective effect on obesity development, but it is unclear how cortisol response to exercise is associated with obesity in adolescents with Down syndrome. This fellowship application, therefore proposes to study how cortisol function mediates the association between fat mass (obesity) and Down syndrome under two conditions: 1) daily living in the natural environment; and 2) in response to a bout of moderate-intensity exercise. Pediatric obesity is significant public health problem, especially in populations with pediatric disabilities. This research will examine a novel mechanism to explain the greater obesity prevalence among youth with Down syndrome. Through studying this mechanism during daily life and in the context of a modifiable health behavior, this proposed study may promote the development of effective interventions and prevention programs in the future. This F31 Pre-doctoral Fellowship seeks to expand my current doctoral training and research potential. The primary goal will be to gain research skills that will enable me to study neuroendocrine and physiological factors that contribute to health disparities and obesity among youth with Down syndrome. The award will provide: 1) more time to focus on the proposed research project; and 2) additional resources to increase my research training in advanced exercise physiology, metabolic endocrinology and the pathophysiology of obesity. The comprehensive training plan and proposed research project will examine a novel mechanism that could better explain obesity in this "at-risk" population. Training will provide me with a rane of research tools to study obesity in populations with pediatric disabilities and develop innovative future interventions to reduce pediatric obesity throughout my career.

描述（由申请人提供）：患有唐氏综合症的青少年中超重和肥胖的患病率超过 50%，并且显着高于一般人群中观察到的比率。这种情况持续到成年，并导致其他继发性健康状况的发展。因此，肥胖是健康差异的主要根源。目前尚不清楚唐氏综合症青少年肥胖患病率较高的原因。糖皮质激素（即皮质醇）功能可能是解释该人群肥胖风险增加的一种新的神经内分泌机制。最近的研究表明，与没有残疾的成年人相比，患有唐氏综合症的年轻人表现出皮质醇失调。下丘脑-垂体-肾上腺 (HPA) 轴和皮质醇功能失调已被证明会促进普通人群体重增加和腹部脂肪量增加。然而，目前尚不清楚患有唐氏综合症的青少年皮质醇功能的差异是否导致肥胖患病率更高。此外，许多解决儿童肥胖问题的干预措施都涉及锻炼。正常的皮质醇对运动的反应预计会对肥胖的发展产生保护作用，但尚不清楚皮质醇对运动的反应如何与唐氏综合症青少年的肥胖相关。因此，该奖学金申请建议研究皮质醇功能如何在两种情况下介导脂肪量（肥胖）和唐氏综合症之间的关联：1）在自然环境中的日常生活； 2）针对一轮中等强度的运动。儿童肥胖是一个重大的公共卫生问题，特别是对于患有儿科残疾的人群。这项研究将探讨一种新机制来解释患有唐氏综合症的青少年中肥胖症患病率较高的原因。通过在日常生活中和可改变的健康行为的背景下研究这种机制，这项拟议的研究可能会促进未来有效干预和预防计划的发展。 F31 博士前奖学金旨在扩大我目前的博士培训和研究潜力。主要目标是获得研究技能，使我能够研究导致唐氏综合症青少年健康差异和肥胖的神经内分泌和生理因素。该奖项将提供：1）更多的时间专注于拟议的研究项目； 2）额外资源，以增加我在高级运动生理学、代谢内分泌学和肥胖病理生理学方面的研究培训。综合培训计划和拟议的研究项目将研究一种新机制，可以更好地解释这一“高危”人群的肥胖现象。培训将为我提供一系列研究工具来研究儿科残疾人群的肥胖，并制定创新的未来干预措施，以在我的整个职业生涯中减少儿科肥胖。