Mechanisms of immune regulation in the skin

描述（由申请人提供）：本提案描述了一个在皮肤免疫学领域发展学术生涯的5年培训计划。该候选人毕业于威斯康星医学院的医学家培训计划（MSTP）。研究生主要研究免疫耐受的基本机制，博士毕业后，结合在医学院三、四年级的学习，开展了皮肤免疫调节的博士后研究项目。他最近毕业于加州大学旧金山分校的皮肤科住院医师，在那里他接受了分子医学医师-科学家培训途径的培训。在他住院期间，以及过去一年作为UCSF初级教员，候选人建立了一种新的小鼠模型来研究皮肤中T细胞介导的免疫反应。通过建议的培训计划，候选人将扩展他的科学技能，成为一名独立的研究者，研究皮肤的基本免疫学。他将通过课程学习、参加研讨会和会议、全国演讲和参与指导的研究项目来实现这一目标。Abul Abbas博士将指导候选人的科学发展。阿巴斯博士是加州大学旧金山分校病理学系的教授和主席，也是免疫耐受领域世界知名的领导者。他指导博士后和研究生的记录非常出色。为了加强候选人的培训，一个由备受尊敬的资深科学家组成的咨询委员会将提供科学和职业建议。咨询委员会将由以下人员组成

DESCRIPTION (provided by applicant): This proposal describes a 5-year training program for the development of an academic career in the field of cutaneous immunology. The candidate graduated from the Medical Scientist Training Program (MSTP) at the Medical College of Wisconsin. His graduate work focused on basic mechanisms of immune tolerance, and upon completion of his doctoral work, the candidate combined his 3rd and 4th years of medical school with a post-doctoral research project on immune regulation in the skin. He recently graduated from a dermatology residency at UCSF where he trained in the Molecular Medicine Physician-Scientist Training Pathway. During his residency, and over the past year as a UCSF junior faculty member, the candidate established a novel mouse model to study T cell-mediated immune responses in the skin. Through the proposed training program, the candidate will expand upon his scientific skills and become and independent investigator studying the basic immunology of the skin. He will accomplish this through coursework, participation in seminars and conferences, national presentations, and engagement in a mentored research project. Dr. Abul Abbas will mentor the candidate's scientific development. Dr. Abbas is Professor and Chairman of the Department of Pathology at UCSF and a world-renowned leader in the field of immune tolerance. His record of mentoring postdoctoral fellows and graduate students is outstanding. To enhance the candidate's training, an advisory committee of highly-regarded senior scientists will provide scientific and career advice. The advisory committee will consist of an immunologist (Dr. Mark Anderson, MD, PhD., Assistant Professor,of Medicine and Endocrinology at UCSF) a cutaneous biologist (Dr. Thea Mauro MD, Professor of Dermatology, UCSF), and a cutaneous geneticist (Dr. Pui-Yan Kwok MD, PhD., Professor of Dermatology, UCSF). Research will focus on uncovering basic mechanisms of immune regulation in the skin. Currently, little is known about how immune responses are controlled in peripheral tissues. Using a novel mouse model of CD4+ T cell-mediated inflammation, the research project will dissect the mechanisms responsible for attenuating these reactions in the skin. The work will focus on regulatory T cells and the PD-1/PD-L1 pathway. In addition, differential gene expression analysis will be utilized to uncover novel mechanisms of both T cell- mediated and keratinocyte-mediated immune regulation. The project will translate results obtained in mice to humans with inflammatory skin disease. The aggregate data will provide a major advancement in our understanding of how T cell-mediated immune responses are regulated in the skin, and have the potential to establish a foundation for novel therapeutic approaches for inflammatory skin disease. The proposed training program draws on the combined resources of the Abbas Laboratory, the UCSF Immunology Program, and the UCSF Department of Dermatology. This will provide an ideal setting for the candidate's transition to an independent investigator.