Impact of drug use on HIV/STI risk across development among African American female adolescents: An integrative data analysis

 描述(由申请人提供)：拟议研究的首要目标是对美国南部非洲裔美国女性青少年中与毒品有关的艾滋病毒和性传播感染(STI)风险进行更准确、更深入的了解。拟议的研究将使用综合数据分析(IDA)方法，汇集和协调在非裔美国女性青少年中进行的4项已完成的艾滋病毒/性传播感染预防试验的现有数据。IDA是对来自多项研究的数据进行同时分析的框架。研究小组将使用加速纵向设计，这是一种通过年龄将多个队列联系起来的方法，以评估青春期吸毒与艾滋病毒/性传播感染风险之间的发展关系。具体地说，拟议的研究将1)创建一个具有协调变量和相应代码簿的汇集数据集，其中结合了在14-24岁非裔美国女性青少年(N=2 243)中进行的4项艾滋病毒/性传播感染预防干预试验的数据。然后，这项研究将使用汇集的统一数据集来：2)检查吸毒行为对性危险行为(例如，多个性伴侣、不戴避孕套的阴道性行为)在青春期发展过程中的自然过程的影响；3)检查吸毒行为对青春期发展中性传播感染的自然过程的影响；4)评估艾滋病毒/性传播感染预防干预措施在多大程度上减少了青春期发展中的吸毒行为。这项研究的结果将有助于推进干预措施，以减少南方非裔美国青少年女性中与毒品有关的艾滋病毒/性传播感染风险。

 DESCRIPTION (provided by applicant): The overarching goal of the proposed research is to yield a more precise, developmental understanding of drug-related HIV and sexually transmitted infection (STI) risk among African American female adolescents in the Southern United States. The proposed study will use an integrative data analysis (IDA) approach to pool and harmonize existing data from 4 completed HIV/STI prevention trials conducted among African American female adolescents. IDA is a framework for conducting simultaneous analysis of data pooled from multiple studies. The study team will use an accelerated longitudinal design, a method for linking multiple cohorts by age, to assess developmental relationships between drug use and HIV/STI risk across adolescence. Specifically, the proposed research will 1) create a pooled data set with harmonized variables and corresponding codebook combining data from 4 HIV/STI prevention intervention trials conducted among African American female adolescents aged 14-24 years (N=2,243). The study will then use the pooled, harmonized dataset to: 2) examine the influence of drug use behaviors on the natural course of sexual risk behavior (e.g., multiple sexual partners, vaginal sex without a condom) across adolescent development; 3) examine the influence of drug use behaviors on the natural course of STI acquisition across adolescent development and 4) evaluate the extent to which HIV/STI prevention interventions reduce drug use behaviors across adolescent development. Findings from this research will be useful for advancing interventions to reduce drug-related HIV/STI risk among African American adolescent females in the South.