DATA COORDINATING CENTER - FASST

这项试验的首要目标是确定包括膳食叶酸和锌补充剂的干预是否能改善接受不孕症治疗的夫妇的精液质量和不孕症治疗结果。如果有效且安全，这种干预将对公共卫生产生相当大的影响，并为精液质量欠佳的男性提供简单而廉价的治疗选择。以下研究目标是成功实现总体研究目标的基础。.评估补充叶酸和硫酸锌对精液质量参数的影响，包括但不限于相对于安慰剂组的浓度、活力、形态和精子DNA片段化。招募、登记和保留大约800对夫妇15个月。数据收集，维护生物样本跟踪系统，用于叶酸和锌补充试验，与生殖健康有关。

The overarching goal of this trial is to determine if an intervention comprising dietary folate and zinc supplementation improves semen quality and infertility treatment outcomes among couples undergoing infertility treatment. If efficacious and safe, such an intervention would have considerable public health impact and afford clinicians a simple and inexpensive treatment option for men with suboptimal semen quality. The following study objective underlie successful attainment of the overarching research goal. . To estimate the effect of folic acid and zinc sulfate supplementation on semen quality parameters, including but not limited to concentration, motility, morphology, and sperm DNA fragmentation relative to the placebo group. Recruit, enroll and retain approximately 800 couples for 15 months. Data collection, maintain biospecimen tracking system, for Folic Acid and Zinc supplement trial, in relation to reproductive health.