DATA COORDINATING CENTER - FASST

本试验的总体目标是确定膳食中补充叶酸和锌的干预措施是否能改善接受不孕症治疗的夫妇的精液质量和不孕症治疗结果。如果有效和安全，这种干预措施将对公共卫生产生相当大的影响，并为临床医生提供一个简单而廉价的治疗选择，以治疗精液质量欠佳的男性。下面的研究目标是成功实现总体研究目标的基础。评估叶酸和硫酸锌补充剂对精液质量参数的影响，包括但不限于相对于安慰剂组的浓度、活力、形态和精子DNA片段。招募、注册并留住约800对夫妇，为期15个月。数据收集，维护生物标本跟踪系统，用于叶酸和锌补充剂试验，与生殖健康有关。

The overarching goal of this trial is to determine if an intervention comprising dietary folate and zinc supplementation improves semen quality and infertility treatment outcomes among couples undergoing infertility treatment. If efficacious and safe, such an intervention would have considerable public health impact and afford clinicians a simple and inexpensive treatment option for men with suboptimal semen quality. The following study objective underlie successful attainment of the overarching research goal. . To estimate the effect of folic acid and zinc sulfate supplementation on semen quality parameters, including but not limited to concentration, motility, morphology, and sperm DNA fragmentation relative to the placebo group. Recruit, enroll and retain approximately 800 couples for 15 months. Data collection, maintain biospecimen tracking system, for Folic Acid and Zinc supplement trial, in relation to reproductive health.