DATA COORDINATING CENTER - FASST

数据协调中心 - FASST

• 批准号: 9460280
• 负责人: TRACI E CLEMONS
• 金额: $ 30.29万
• 依托单位: THE EMMES COMPANY, LLC
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-02-06 至 2018-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9460280
• 关键词: Clinical; Couples; DNA; DNA Fragmentation; Data Collection; Data Coordinating Center; Diet; Embryo; Enrollment; Fertilization; Fertilization in Vitro; Folic Acid; Goals; Human Chorionic Gonadotropin; Incidence; Intervention; Intracytoplasmic Sperm Injections; Morphology; Placebos; Pregnancy; Procedures; Public Health; Recruitment Activity; Reproductive Health; Research; Seminal fluid; Supplementation; System; Treatment outcome; Zinc Sulfate; Zinc supplementation; cell motility; folic acid supplementation; implantation; improved; infertility treatment; men; sperm cell

The overarching goal of this trial is to determine if an intervention comprising dietary folate and zinc supplementation improves semen quality and infertility treatment outcomes among couples undergoing infertility treatment. If efficacious and safe, such an intervention would have considerable public health impact and afford clinicians a simple and inexpensive treatment option for men with suboptimal semen quality. The following study objective underlie successful attainment of the overarching research goal. . To estimate the effect of folic acid and zinc sulfate supplementation on semen quality parameters, including but not limited to concentration, motility, morphology, and sperm DNA fragmentation relative to the placebo group. Recruit, enroll and retain approximately 800 couples for 15 months. Data collection, maintain biospecimen tracking system, for Folic Acid and Zinc supplement trial, in relation to reproductive health. NOTE: Supports Z1AHD008943 915088

这项试验的首要目标是确定在接受不孕症治疗的夫妇中，包括饮食叶酸和锌补充的干预措施是否改善了精液质量和不育治疗结果。如果有效和安全，这种干预将会对公众健康产生相当大的影响，并为临床医生提供一种简单而廉价的治疗方案，用于治疗精液质量不佳的男性。以下研究目标是成功实现总体研究目标的基础。。评估补充叶酸和硫酸锌对精液质量参数的影响，包括但不限于浓度、活力、形态和精子DNA片段化。招募、登记和保留约800对夫妇，为期15个月。收集数据，维护生物素跟踪系统，用于叶酸和锌补充试验，与生殖健康有关。注：支持Z1AHD008943 915088