Kinomics and Synaptic Vesicle Endocytosis

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Brain diseases such as epilepsy and Alzheimer�s are linked to the activation of synapses, contact points between nerve cells. Synapses absorb and release neurotransmitters in the cyclic process of endocytosis & exocytosis allowing nerve cell communication. This study aims to identify the master controllers, protein kinases, which are essential to reset the process after each cycle. These proteins can be exploited as targets in drug discovery programs to treat common neurological diseases.