Vaccination design based on natural env genes to elicit broad neutralizing Abs

基于天然 env 基因的疫苗设计可引发广泛的中和抗体

• 批准号: 8913417
• 负责人: Nancy L Haigwood
• 金额: $ 35.47万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-16 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8913417
• 关键词: Antigens; Autologous; Complement component C1; DNA Vaccines; Development; Gagging; Genes; HIV; HIV vaccine; Immune response; Immunity; In Vitro; Individual; Oryctolagus cuniculus; Patients; Plasma; Populations at Risk; Recombinant DNA; Sampling; Severities; Subunit Vaccines; Testing; Vaccinated; Vaccination; Vaccines; Variant; Viral Genome; Work; base; cohort; comparative; design; env Genes; env Glycoproteins; gp160; immunogenicity; neutralizing antibody; novel vaccines; programs; research study; response

This project seeks to develop novel vaccines that can be delivered as DNA vaccine components to produce strong neutralizing antibodies. The immunity produced by these vaccines, if successful, can be optimized and then tailored to work in combination with other HIV vaccines to vaccinate at-risk populations and reduce acquisition or severity of HIV.

该项目旨在开发新型疫苗，使其可以作为DNA疫苗的成分来生产