Neuromodulation of Motivated Cognition and Decision Making Across Adulthood

成年期动机认知和决策的神经调节

• 批准号: 8930036
• 负责人: Gregory R Samanez Larkin
• 金额: $ 23.88万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8930036
• 关键词: Adult; Affect; Age; Aging; Amygdaloid structure; Anterior; Autoreceptors; Award; Behavior Control; Behavioral; Behavioral Research; Binding; Biological Neural Networks; Biological Preservation; Brain; Cognition; Cognitive; Cognitive aging; Collaborations; Computer Simulation; Corpus striatum structure; Cross-Sectional Studies; Data; Decision Making; Development; Dopamine; Elderly; Emotional; Emotions; Functional Magnetic Resonance Imaging; Future; Globus Pallidus; Goals; Health; Human; Image; Imaging Techniques; Incentives; Individual; Individual Differences; Informal Social Control; Intervention; Laboratories; Lateral; Link; Longevity; Measures; Mentors; Midbrain structure; Motivation; Motor; Multimodal Imaging; Neurobiology; Neurophysiology - biologic function; Neurosciences; Neurotransmitters; Participant; Pathway interactions; Patient Self-Report; Pattern; Performance; Phase; Play; Positron-Emission Tomography; Postdoctoral Fellow; Protocols documentation; Psychological Theory; Relative (related person); Research; Retirement; Rewards; Role; Sampling; Scientist; Series; Signal Transduction; Staging; Surveys; System; Techniques; Testing; Translational Research; Ventral Striatum; Work; age difference; age related; base; behavior measurement; behavioral economics; career; cognitive ability; cognitive control; cognitive function; design; discounting; dopamine system; executive function; experience; frontal lobe; improved; knowledge base; neuroimaging; neuroregulation; phase 1 study; phase 3 study; phase 4 study; processing speed; programs; psychological aspect of aging; radioligand; receptor; receptor binding; relating to nervous system; reward processing; skills; theories; trait; young adult

PROJECT SUMMARY/ABSTRACT The goal of this Pathway to Independence Award is to expand the base of knowledge, methodological expertise, and theoretical development skills of the candidate as he transitions from a post-doctoral trainee to an independent scientist focused on the decision neuroscience of aging. A wealth of behavioral research on the psychology of aging reveals change over the life span in both cognition and motivation. Many prominent theories of cognitive aging are centered on changes in neuromodulation, focusing specifically on the neurotransmitter dopamine (DA). However, DA is not only implicated in variability in cognitive function, but also plays an important role in motivation. Yet, the relation between age-related changes in DA functioning and motivational factors has received little study. The goal of the initial K99 mentored phase is to begin to examine interactions between motivation and cognition across adulthood, increase the candidate's base of knowledge of the dopamine system, gain experience with computational modeling, and expand the candidate's expertise with multiple imaging measures. To achieve these goals, the candidate will conduct a collaborative multimodal imaging project focused on clarifying the link between DA functioning and self regulation (R21-DA033611). The project will include behavioral and fMRI measures of inhibitory control as well as PET measures of receptor availability across the brain in a group of healthy adults. All participants will complete two behavioral tasks that capture distinct aspects of motivated cognitive control and engage distinct, albeit overlapping neural networks. The candidate will begin to extend this line of work as well as his previous work on age differences in decision making into a cross-sectional study of age differences in motivated cognition and decision making in this K99 phase. The proposed R00 project will examine relationships between motivated cognitive control and decision making across adulthood (ages 20-80). In addition to a PET scan, subjects will complete behavioral tasks while undergoing fMRI that assess reward processing and inhibitory control. Participants will also complete a full battery of cognitive and motivational individual difference measures, incentive-compatible behavioral economics tasks, as well as a subset of the Health and Retirement Study (HRS) survey. This project will also serve as a foundational study for the development of a longitudinal multi-modal imaging protocol. Together, the mentored and independent phases of this project will provide a framework toward developing a more integrative and comprehensive theory of human aging that incorporates neuroscientific theories of the role of DA function for cognition and motivation with psychological theories of aging. A long-term goal of the candidate's career is to develop a computationally-informed and neurobiologically-specific theory of motivated cognition across adult development and aging. Support through this mechanism will greatly increase the likelihood of the candidate's obtaining an R01 to support a longitudinal multimodal imaging study at an earlier career stage than otherwise possible.

项目总结/文摘