课题基金 / 基金详情

项目摘要

项目成果

GRAHAM S TIMMINS的其他基金

相似基金

相关文献

中文摘要
翻译

英文摘要
 DESCRIPTION (provided by applicant): Pyrazinamide (PZA) is a critical drug for treating tuberculosis (TB) because of its potent sterilizing activity. PZA is a prodrug, activated by pyrazinamidase to the antimycobacterial product pyrazinoic acid (POA) and ammonia. Resistance against PZA is dominated by mutations in pncA that decrease PZA activation. PZA resistance is becoming of great concern because it is so important in therapy, resistance is increasing and conventional resistance detection is difficult and slow in practice. We propose a rapid, robust, simple and point-of-care (POC) approach that delivers biochemical PZA resistance data during the time of a typical patient-doctor visit. Stable isotope 15N-amide labeled PZA is directly delivered to the lung by inhaler or nebulizer. Mycobacterial pyrazinamidase then converts it to POA and 15N-ammonia that is then exhaled and detected in breath. We will perform in vitro and in vivo studies to characterize and validate this approach.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Rifampin potentiation in NTM
  • 批准号:
    9908969
  • 项目类别:
  • 资助金额:
    $20.53万
  • 财政年份:
    2020
  • 负责人:
    GRAHAM S TIMMINS
  • 依托单位:
Reversing Isoniazid Resistance By Isotopic Substitution
  • 批准号:
    9347156
  • 项目类别:
  • 资助金额:
    $58.64万
  • 财政年份:
    2017
  • 负责人:
    GRAHAM S TIMMINS
  • 依托单位:
Breath Test for Pseudomonas aeruginosa in CF
  • 批准号:
    7571290
  • 项目类别:
  • 资助金额:
    $18.75万
  • 财政年份:
    2009
  • 负责人:
    GRAHAM S TIMMINS
  • 依托单位:
Breath Test for Pseudomonas aeruginosa in CF
  • 批准号:
    7895581
  • 项目类别:
  • 资助金额:
    $22.5万
  • 财政年份:
    2009
  • 负责人:
    GRAHAM S TIMMINS
  • 依托单位:
国内基金
海外基金
SIRT5/ammonia信号通路介导适应性自噬在急性心肌梗死中的作用及其机制研究
  • 批准号:
    81900312
  • 项目类别:
    青年科学基金项目
  • 资助金额:
    20.0万元
  • 批准年份:
    2019
  • 负责人:
    汪芸玏
  • 依托单位: