2014 New Antibacterial Discovery and Development Gordon Research Conference

总结 抗生素的发现及其在20世纪40年代引入临床实践从根本上改变了 医学，为现代医疗保健提供支柱，并改变公共卫生格局。的 抗药性细菌增加和扩散严重侵蚀了这些成果。抗老线 抗生素（例如青霉素和大环内酯类）在社区和医院分离株中很常见。多药 耐药性是医院沙门氏菌菌株的标准。金黄色葡萄球菌和肠球菌， 在像E.大肠杆菌和克雷伯氏菌属。随着广谱β-内酰胺酶的出现 (e.g. KPC，NDM），甚至碳青霉烯类，传统的严重革兰氏阴性菌感染的最后一线药物， 被淘汰而转而使用更古老的高毒性药物如粘菌素具有极强的抗药性甚至泛- 假单胞菌和不动杆菌的耐药菌株不再是闻所未闻的。正如许多人所指出的那样， 评论员，调查人员，临床医生和监管机构，我们面临着一个非常真实的可能性，回到前， 抗生素时代，我们治疗细菌性疾病的能力，也有失去其他医疗服务的巨大风险。 进步（例如实体器官移植，假体关节植入，甚至许多常规手术）， 抗生素使之成为可能。最终，这次会议的目标是产生想法， 我们必须进行研究，以防止这一事件的发生，并防止由此产生的严重后果。 2014年戈登研究会议（GRC）新的抗菌发现和发展将带来 汇集了国际行业、学术界、政府和基金会领导人，致力于 新的、安全有效的抗菌剂的发现和开发。生物学家化学家， 临床医生和监管机构将有机会在正式的演讲，海报会议， 重要的是，非正式的谈话和聚会是一个GRC的标志。会议 制定了议程，以最大限度地增加从相关领域学习的机会，并引入新的声音 我们的谈话以前的会议在科学上是令人兴奋的和开放的， 评估该领域面临的挑战以及旨在应对这些挑战的新合作。 每一个介绍。该地点非常适合这种交流和会议的结构 我们致力于最广泛的参与，特别是让该领域的年轻成员参加。 - 选择讨论领导者的目的是围绕 遵循经典的GRC格式。我们请求为这次重要会议提供补充财政支助。

Summary The discovery of antibiotics and their introduction into clinical practice in the 1940s fundamentally changed medicine, providing the backbone for modern healthcare and transforming the public health landscape. The increase and spread of antibiotic-resistant bacteria have seriously eroded these gains. Resistance to old line antibiotics (e.g. penicillins and macrolides) is common among community and hospital isolates. Multidrug resistance is the norm in hospital strains of S. aureus and Enterococcus and is becoming increasingly prevalent in organisms like E. coli and Klebsiella. With the advent of even broader spectrum beta-lactamases (e.g. KPC, NDM) even the carbapenems, traditional last line agents for serious Gram-negative infections, are being sidelined in favor of older, highly toxic drugs like colistin. Extremely drug resistant and even pan- resistant strains of Pseudomonas and Acinetobacter are no longer unheard of. As has been noted by many commentators, investigators, clinicians and regulators, we face a very real possibility of a return to the pre- antibiotic era in terms of our ability to treat bacterial disease and are also at great risk of losing other medical advances (e.g. solid organ transplantation, prosthetic joint implants, and even many routine surgeries) that antibiotics have made possible. Ultimately, it is the goal of this conference to generate ideas and advance research to forestall that event and to prevent the serious consequences that would inexorably come from it. The 2014 Gordon Research Conference (GRC) on New Antibacterial Discovery and Development will bring together an international cross section of industry, academic, government and foundation leaders committed to the discovery and development of novel, safe and effective antibacterial agents. Biologists, chemists, clinicians and regulators will have the opportunity to interact in formal presentations, poster sessions and, most importantly, the informal conversations and gatherings that are the hallmark of a GRC. The conference agenda has been crafted to maximize the opportunity to learn from related fields and to introduce new voices to the conversation. Previous meetings have been scientifically exciting and open, resulting in frank assessment of challenges facing the field as well as new collaborations aimed at tackling these challenges. each of the presentations. The site is well suited for this interchange and the structure of the Conference We are dedicated to the broadest participation, particularly the inclusion of younger members of the field. - Discussion Leaders have been chosen with an eye toward generating robust, insightful discussion around follows the classical GRC format. We request supplementary financial support for this important gathering.