2014 New Antibacterial Discovery and Development Gordon Research Conference

摘要 20世纪40年代抗生素的发现和临床应用从根本上改变了 医学，为现代医疗保健提供支柱，并改变公共卫生格局。这个 抗药性细菌的增加和传播严重侵蚀了这些成果。对老品系的抗性 抗生素(如青霉素和大环内酯类)在社区和医院分离株中很常见。多药联用 耐药性是医院内金黄色葡萄球菌和肠球菌的常态，并正在变得越来越多 广泛存在于大肠杆菌和克雷伯氏菌等生物体中。随着更广泛的β-内酰胺酶的出现 (例如，KPC，NDM)即使是碳青霉烯类，传统的治疗严重革兰氏阴性感染的最后一线药物，也是 对粘菌素这样的老的、剧毒的药物的青睐被排挤在外。抗药性极强，甚至泛滥- 假单胞菌和不动杆菌耐药菌株不再是闻所未闻的。正如许多人所注意到的那样 评论员、调查人员、临床医生和监管机构，我们面临着非常真实的可能性，回到之前的 抗生素时代，就我们治疗细菌疾病的能力而言，也面临着失去其他医学知识的巨大风险 进展(例如实体器官移植、假肢关节植入，甚至许多常规手术) 抗生素使之成为可能。归根结底，这次会议的目标是产生想法和推动 研究预防这一事件，并防止它将不可避免地产生严重后果。 2014戈登研究会议(GRC)关于新的抗菌药物的发现和开发将带来 由行业、学术、政府和基金会领导人组成的国际跨部门共同致力于 发现和开发新型、安全、有效的抗菌剂。生物学家、化学家、 临床医生和监管机构将有机会在正式演示文稿、海报会议和大多数 重要的是，非正式的对话和聚会是GRC的标志。这次会议 已经制定了议程，以最大限度地提供向相关领域学习和引入新声音的机会 在谈话中。之前的会议都是科学上令人兴奋和开放的，结果是坦率 评估外地面临的挑战以及旨在应对这些挑战的新的合作。 每一场演讲。会址非常适合这种交流和会议的结构。 我们致力于最广泛的参与，特别是吸纳实地的年轻成员。 - 选择讨论领导者的目的是为了在以下方面产生强有力的、有洞察力的讨论 遵循经典的GRC格式。我们请求为这次重要会议提供补充财政支持。

Summary The discovery of antibiotics and their introduction into clinical practice in the 1940s fundamentally changed medicine, providing the backbone for modern healthcare and transforming the public health landscape. The increase and spread of antibiotic-resistant bacteria have seriously eroded these gains. Resistance to old line antibiotics (e.g. penicillins and macrolides) is common among community and hospital isolates. Multidrug resistance is the norm in hospital strains of S. aureus and Enterococcus and is becoming increasingly prevalent in organisms like E. coli and Klebsiella. With the advent of even broader spectrum beta-lactamases (e.g. KPC, NDM) even the carbapenems, traditional last line agents for serious Gram-negative infections, are being sidelined in favor of older, highly toxic drugs like colistin. Extremely drug resistant and even pan- resistant strains of Pseudomonas and Acinetobacter are no longer unheard of. As has been noted by many commentators, investigators, clinicians and regulators, we face a very real possibility of a return to the pre- antibiotic era in terms of our ability to treat bacterial disease and are also at great risk of losing other medical advances (e.g. solid organ transplantation, prosthetic joint implants, and even many routine surgeries) that antibiotics have made possible. Ultimately, it is the goal of this conference to generate ideas and advance research to forestall that event and to prevent the serious consequences that would inexorably come from it. The 2014 Gordon Research Conference (GRC) on New Antibacterial Discovery and Development will bring together an international cross section of industry, academic, government and foundation leaders committed to the discovery and development of novel, safe and effective antibacterial agents. Biologists, chemists, clinicians and regulators will have the opportunity to interact in formal presentations, poster sessions and, most importantly, the informal conversations and gatherings that are the hallmark of a GRC. The conference agenda has been crafted to maximize the opportunity to learn from related fields and to introduce new voices to the conversation. Previous meetings have been scientifically exciting and open, resulting in frank assessment of challenges facing the field as well as new collaborations aimed at tackling these challenges. each of the presentations. The site is well suited for this interchange and the structure of the Conference We are dedicated to the broadest participation, particularly the inclusion of younger members of the field. - Discussion Leaders have been chosen with an eye toward generating robust, insightful discussion around follows the classical GRC format. We request supplementary financial support for this important gathering.