Animal Models, Stem Cells and Cell Therapy

动物模型、干细胞和细胞治疗核心通过提供独特的资源、技术和科学专业知识，以节省成本，促进了Marion Bessin肝脏研究中心的转化研究。自中心更新以来，核心进行了重组，保留了所有以前的服务，并根据中心调查员不断变化的需求提供了额外的服务。核心在尖端技术和资源方面积累了广泛的专业知识，用于使用各种肝细胞类型（包括干细胞）以及独特的动物模型进行研究。这有利于中心研究人员从事病理生理机制或细胞和基因治疗的基础研究。例如，通过疾病模型的专业知识，高质量细胞制剂的分布，为中心研究人员创造了令人兴奋的机会，这有助于代谢缺乏状态，遗传疾病，辐射损伤和急性或慢性肝衰竭的新治疗发展。同时，在肝脏基因表达、干细胞/祖细胞生物学、炎症、自噬、肝脏生长控制、肝脏转运的病理生理机制等方面也进行了大量的研究。同样，教育活动定位核心

The Animal Models, Stem Cells and Cell Therapy Core facilitates translational research in the Marion Bessin Liver Research Center by providing unique resources, technologies and scientific expertise at cost savings. The Core was reorganized since previous the Center renewal, preserving all previous services and including additional services in response to the evolving needs of Center Investigators. The Core has accumulated extensive expertise in cutting-edge technologies and resources for studies using various liver cell types, including stem cells, as well as unique animal models. This benefits Center Investigators pursuing basic studies of pathophysiological mechanisms or cell and gene therapy. For instance, exciting opportunities are generated for Center Investigators through expertise in disease models, distribution of high quality cell preparations, which were instrumental for novel therapeutic developments in metabolic deficiency states, genetic diseases, radiation injury and acute or chronic liver failure. Simultaneously, numerous studies were advanced in hepatic gene expression, stem/progenitor cell biology, inflammation, autophagy, liver growth control, pathophysiological mechanisms of liver transport. Similarly, educational activities position the Core as an important resource. The Aims of this Core are as follows: To breed, maintain and provide animals that are not readily available from other sources, " To develop or reproduce relevant induced animal models. To isolate and distribute high quality primary animal or human liver cells, " To provide liver cells generated from pluripotent stem cells using highly efficient protocols, " To instruct investigators in stem cell methods and commonly used animal procedures, " To offer consultation for experimental design for animal studies To provide optimized, cost-effective liver cell culture conditions and additives, " To incorporate new technologies for animal and human stem cell and cell therapy studies, " To encourage use of the Core by early-stage investigators or investigators new to liver research.