Special Animal Core

人类疾病的动物模型构成了中心研究人员不可或缺的手段。 肝细胞移植、基因治疗和肝脏病理生理学的研究仍然是主要焦点。 中心的一部分。现在，特殊动物核心在古普塔博士的专家指导下继续蓬勃发展 进入第二个十年。在之前的资助期间，中心向中心提供服务 调查人员，以及肝脏中心和医学院以外的调查人员。 该中心提供动物，以促进有关开发治疗方法的研究 代谢缺陷状态、遗传性肝病以及急性或慢性肝功能衰竭。此外, 由Core提供的动物促进肝脏基因表达、祖细胞和干细胞的研究 细胞生物学和肝脏生长控制。由于在体内进行了许多研究，使用具有良好特性的 具有独特遗传特征的动物模型一直是无价的，并将继续如此 未来。

Animal models of human disease constitute an indispensable modality for Center Investigators. Studies of liver cell transplantation, gene therapy and hepatic pathophysiology remain a major focus of the Center. The Special Animal Core continues to thrive under Dr. Gupta's expert direction, now well into its second decade. During previous funding periods, the Core provided services to Center Investigators, as well as to investigators outside of the Liver Center and the College of Medicine. Animals are provided by the Core to facilitate studies concerning development of therapies for metabolic deficiency states, genetic liver disease, and acute or chronic liver failure. In addition, animals provided by the Core facilitate studies of hepatic gene expression, progenitor cell and stem cell biology, and liver growth control. With many studies performed in vivo, use of well-characterized animal models with unique genetic characteristics has been invaluable and will remain so in the future.