Special Animal Core

特殊动物核心

• 批准号: 7688362
• 负责人: SANJEEV GUPTA
• 金额: $ 15.52万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7688362
• 关键词: Animal Model; Animals; Attention; Biodistribution; Breeding; Cell Transplantation; Cells; Characteristics; Chronic; Consultations; Development; Disease; Experimental Designs; Functional disorder; Funding; Future; Gene Expression; Genes; Genetic; Growth; Hepatic; Hepatocyte; Liver; Liver Failure; Medicine; Metabolic; Mission; Modality; Modeling; Operative Surgical Procedures; Procedures; Radiolabeled; Research; Research Personnel; Resources; Services; Small Intestines; Stem Cell Research; Stem cells; Training; Transplanted tissue; Work; acute liver disease; cell type; college; gene therapy; human disease; imaging modality; in vivo; liver function; radiotracer; stem cell biology; therapy development

Animal models of human disease constitute an indispensable modality for Center Investigators. Studies of liver cell transplantation, gene therapy and hepatic pathophysiology remain a major focus of the Center. The Special Animal Core continues to thrive under Dr. Gupta's expert direction, now well into its second decade. During previous funding periods, the Core provided services to Center Investigators, as well as to investigators outside of the Liver Center and the College of Medicine. Animals are provided by the Core to facilitate studies concerning development of therapies for metabolic deficiency states, genetic liver disease, and acute or chronic liver failure. In addition, animals provided by the Core facilitate studies of hepatic gene expression, progenitor cell and stem cell biology, and liver growth control. With many studies performed in vivo, use of well-characterized animal models with unique genetic characteristics has been invaluable and will remain so in the future.

人类疾病的动物模型是中心研究者不可或缺的模式。 肝细胞移植、基因治疗和肝脏病理生理学的研究仍然是一个主要焦点 的中心。在古普塔博士的专家指导下，特殊动物核心继续蓬勃发展，现在， 进入第二个十年。在以前的供资期间，核心小组向中心提供服务， 研究人员，以及肝脏中心和医学院以外的研究人员。 动物由中心提供，以促进关于以下疾病治疗方法开发的研究： 代谢缺陷状态、遗传性肝病和急性或慢性肝功能衰竭。此外，本发明还提供了一种方法， 由核心提供的动物促进了肝脏基因表达、祖细胞和干细胞的研究 细胞生物学和肝脏生长控制。随着许多体内研究的进行，使用良好表征的 具有独特遗传特征的动物模型一直是非常宝贵的，并将继续在 未来