Effect of Aerobic Exercise on Genomic Signatures of Prostate Cancer Prognosis
有氧运动对前列腺癌预后基因组特征的影响
基本信息
- 批准号:8615849
- 负责人:
- 金额:$ 66.28万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2014
- 资助国家:美国
- 起止时间:2014-04-14 至 2019-02-28
- 项目状态:已结题
- 来源:
- 关键词:AddressAdherenceAdoptionAdverse effectsAerobic ExerciseAffectAnxietyBase Excision RepairsBiologicalBiologyBiopsyCaliforniaCancer BiologyCancer PrognosisCancer SurvivorCessation of lifeClinicalComorbidityControl GroupsDNA RepairDNA Repair PathwayDataDevelopmentDiagnosisDiseaseDisease ProgressionErectile dysfunctionExerciseFutureGene ExpressionGenomicsGleason Grade for Prostate CancerGoalsGrantGrowth FactorHome environmentHumanIncontinenceIndolentLeadLongitudinal StudiesMalignant NeoplasmsMalignant neoplasm of prostateMessenger RNAMitogen-Activated Protein Kinase 14MusNeoplasm MetastasisNormal tissue morphologyOutcomePathologicPathway interactionsPatternPhase III Clinical TrialsPhenotypePhosphatidylinositolsPhosphotransferasesPhysical activityPlasmaProbabilityPrognostic MarkerProstateProstate Cancer therapyProstate-Specific AntigenProstatic NeoplasmsProtocols documentationPublic HealthRNARadiosurgeryRandomized Controlled TrialsRecommendationReportingResearchRiskSan FranciscoSignal PathwaySignal TransductionStagingStressTestingTimeTissuesToxic effectTumor TissueUnited StatesUniversitiesVascular Endothelial Growth FactorsVascularizationWalkingWorkadverse outcomeangiogenesisarmbasecancer diagnosiscohortdisorder riskfitnessfollow-uphigh riskimprovedlifestyle interventionmRNA Expressionmennovelpost interventionprogramspsychosocialpublic health prioritiespublic health relevancetreatment as usualtumortumor progression
项目摘要
Title: Effect of Aerobic Exercise on Genomic Signatures of Prostate Cancer Prognosis:
7. PROJECT SUMMARY/ABSTRACT:
Prostate cancer is the most commonly diagnosed cancer among men in the United States with more than
241,000 new diagnoses in 2012. Nearly half of the men diagnosed have early stage, low-grade disease, and
may be good candidates for active surveillance (AS). AS is an important management option because it
reduces overtreatment, including the serious side effects (e.g., incontinence, erectile dysfunction) of standard
prostate cancer therapies. However, AS is under-utilized because current clinical tests are imperfect at
discerning indolent from aggressive prostate cancer. Furthermore, approximately 15% of men who initially
opt for AS ultimately seek curative treatment in the absence of biological progression, due to the anxiety and
stress of knowing they have cancer. Hence, identifying strategies that reduce risk of prostate cancer
progression and allay AS-specific anxiety could greatly reduce the overtreatment of low risk prostate cancer
and benefit public health. We reported that vigorous physical activity and brisk walking after prostate cancer
diagnosis were associated with ~60% reductions in prostate cancer progression or death in two distinct cohorts
of men with prostate cancer. While compelling, these studies do not address if increasing aerobic exercise after
diagnosis favorably alters prostate cancer biology. Our group and others have identified and validated novel
prostate genomic signatures that predict poor clinical outcomes among men with low risk prostate cancer, and
demonstrated that gene expression in the prostate is modified by short-term lifestyle interventions. Thus, we
propose to conduct a randomized controlled trial to evaluate whether 24 weeks of supervised aerobic
exercise vs. usual care affects the expression of three validated prostate genomic signatures among 120 men
with prostate cancer on AS at the University of California, San Francisco and Duke University. Men assigned
to the exercise arm will participate in an individually tailored treadmill-walking program that includes five 30-
45 minute sessions per week at 50-80% of baseline cardiorespiratory fitness (three supervised, two at home).
We will also examine the global effects of aerobic exercise on mRNA expression of cancer-related pathways in
tumor and normal tissue (e.g. growth factor signaling, angiogenesis, DNA repair); and whether aerobic
exercise reduces AS-related anxiety and overall stress compared to usual care. The AS protocol of regular
prostate biopsies provides a unique opportunity to study the longitudinal effects of aerobic exercise on
prostate cancer biology. The results of this randomized controlled trial will provide the essential evidence
needed to support a definitive phase III clinical trial of exercise and prostate cancer progression.
标题:有氧运动对前列腺癌预后基因组特征的影响:
7.项目总结/摘要:
前列腺癌是美国男性中最常见的癌症,
2012年新诊断241,000例。近一半的男性诊断为早期,低度疾病,
可能是主动监视(AS)的良好候选人。AS是一个重要的管理选项,因为它
减少过度治疗,包括严重的副作用(例如,失禁,勃起功能障碍)的标准
前列腺癌的治疗然而,由于目前的临床试验不完善,
区分惰性和侵袭性前列腺癌。此外,大约15%的男性最初
选择AS最终在没有生物进展的情况下寻求治愈性治疗,由于焦虑和
知道自己得了癌症的压力因此,确定降低前列腺癌风险的策略
进展和减轻AS特异性焦虑可以大大减少低风险前列腺癌的过度治疗
有益于公众健康。我们报告说,前列腺癌后剧烈的体力活动和快走
在两个不同的队列中,诊断与前列腺癌进展或死亡减少约60%相关
前列腺癌的患者。虽然令人信服,但这些研究并没有解决在运动后增加有氧运动的问题。
诊断有利地改变前列腺癌生物学。我们的团队和其他人已经确定并验证了新的
预测低风险前列腺癌男性临床结局较差的前列腺基因组特征,以及
研究表明,前列腺中的基因表达通过短期生活方式干预而改变。因此我们
我建议进行一项随机对照试验,以评估是否24周的监督有氧运动
运动与常规护理影响120名男性中三种经验证的前列腺基因组特征的表达
在加州大学、弗朗西斯科大学和杜克大学,分配的男子
到锻炼手臂将参加一个单独定制的跑步机步行计划,其中包括五个30-
每周45分钟的训练,心肺功能达到基线的50-80%(三次监督,两次在家)。
我们还将研究有氧运动对癌症相关通路mRNA表达的整体影响,
肿瘤和正常组织(例如生长因子信号传导、血管生成、DNA修复);以及是否需氧
与常规护理相比,运动减少了AS相关的焦虑和整体压力。规则的AS协议
前列腺活检提供了一个独特的机会来研究有氧运动对前列腺的纵向影响。
前列腺癌生物学这项随机对照试验的结果将提供必要的证据,
需要支持一项关于运动和前列腺癌进展的确定性III期临床试验。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
JUNE ML CHAN其他文献
JUNE ML CHAN的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('JUNE ML CHAN', 18)}}的其他基金
Short Courses on the Conduct of Reproducible Aging Research with Big Data
利用大数据进行可重复衰老研究的短期课程
- 批准号:
10501970 - 财政年份:2022
- 资助金额:
$ 66.28万 - 项目类别:
Short Courses on the Conduct of Reproducible Aging Research with Big Data
利用大数据进行可重复衰老研究的短期课程
- 批准号:
10681414 - 财政年份:2022
- 资助金额:
$ 66.28万 - 项目类别:
Effect of Aerobic Exercise on Genomic Signatures of Prostate Cancer Prognosis
有氧运动对前列腺癌预后基因组特征的影响
- 批准号:
9243994 - 财政年份:2014
- 资助金额:
$ 66.28万 - 项目类别:
Prostate Microenvironmental & Prostate Cancer Progression
前列腺微环境
- 批准号:
7282354 - 财政年份:2006
- 资助金额:
$ 66.28万 - 项目类别:
Prostate Microenvironmental & Prostate Cancer Progression
前列腺微环境
- 批准号:
7048051 - 财政年份:2006
- 资助金额:
$ 66.28万 - 项目类别:
Prostate Microenvironmental & Prostate Cancer Progression
前列腺微环境
- 批准号:
7485604 - 财政年份:2006
- 资助金额:
$ 66.28万 - 项目类别:
Prostate Microenvironmental & Prostate Cancer Progression
前列腺微环境
- 批准号:
7666279 - 财政年份:2006
- 资助金额:
$ 66.28万 - 项目类别:
相似海外基金
An innovative, AI-driven prehabilitation platform that increases adherence, enhances post-treatment outcomes by at least 50%, and provides cost savings of 95%.
%20创新、%20AI驱动%20康复%20平台%20%20增加%20依从性、%20增强%20治疗后%20结果%20by%20at%20至少%2050%、%20和%20提供%20成本%20节省%20of%2095%
- 批准号:
10057526 - 财政年份:2023
- 资助金额:
$ 66.28万 - 项目类别:
Grant for R&D
Improving Repositioning Adherence in Home Care: Supporting Pressure Injury Care and Prevention
提高家庭护理中的重新定位依从性:支持压力损伤护理和预防
- 批准号:
490105 - 财政年份:2023
- 资助金额:
$ 66.28万 - 项目类别:
Operating Grants
I-Corps: Medication Adherence System
I-Corps:药物依从性系统
- 批准号:
2325465 - 财政年份:2023
- 资助金额:
$ 66.28万 - 项目类别:
Standard Grant
Unintrusive Pediatric Logging Orthotic Adherence Device: UPLOAD
非侵入式儿科记录矫形器粘附装置:上传
- 批准号:
10821172 - 财政年份:2023
- 资助金额:
$ 66.28万 - 项目类别:
Nuestro Sueno: Cultural Adaptation of a Couples Intervention to Improve PAP Adherence and Sleep Health Among Latino Couples with Implications for Alzheimer’s Disease Risk
Nuestro Sueno:夫妻干预措施的文化适应,以改善拉丁裔夫妇的 PAP 依从性和睡眠健康,对阿尔茨海默病风险产生影响
- 批准号:
10766947 - 财政年份:2023
- 资助金额:
$ 66.28万 - 项目类别:
CO-LEADER: Intervention to Improve Patient-Provider Communication and Medication Adherence among Patients with Systemic Lupus Erythematosus
共同领导者:改善系统性红斑狼疮患者的医患沟通和药物依从性的干预措施
- 批准号:
10772887 - 财政年份:2023
- 资助金额:
$ 66.28万 - 项目类别:
Pharmacy-led Transitions of Care Intervention to Address System-Level Barriers and Improve Medication Adherence in Socioeconomically Disadvantaged Populations
药房主导的护理干预转型,以解决系统层面的障碍并提高社会经济弱势群体的药物依从性
- 批准号:
10594350 - 财政年份:2023
- 资助金额:
$ 66.28万 - 项目类别:
Antiretroviral therapy adherence and exploratory proteomics in virally suppressed people with HIV and stroke
病毒抑制的艾滋病毒和中风患者的抗逆转录病毒治疗依从性和探索性蛋白质组学
- 批准号:
10748465 - 财政年份:2023
- 资助金额:
$ 66.28万 - 项目类别:
Improving medication adherence and disease control for patients with multimorbidity: the role of price transparency tools
提高多病患者的药物依从性和疾病控制:价格透明度工具的作用
- 批准号:
10591441 - 财政年份:2023
- 资助金额:
$ 66.28万 - 项目类别:
Development and implementation of peer-facilitated decision-making and referral support to increase uptake and adherence to HIV pre-exposure prophylaxis in African Caribbean and Black communities in Ontario
制定和实施同行协助决策和转介支持,以提高非洲加勒比地区和安大略省黑人社区对艾滋病毒暴露前预防的接受和依从性
- 批准号:
491109 - 财政年份:2023
- 资助金额:
$ 66.28万 - 项目类别:
Fellowship Programs