Bioinformatics Core

核心B，摘要/摘要 肿瘤病毒作用的分子机制研究有赖于数据密集型科学研究。 接近了。作为回应，生物信息学核心旨在1)提供计算专业知识和服务 在此计划中的所有项目中，2)部署用于存储和共享的数据管理解决方案 项目生成的数据，以及3)提供促进特定项目研究机会的论坛 面向广泛的信息学实习生和教职员工。一个主要的重点是提供及时的生物信息学 建议和分析，并提供关于使用生物信息学工具和/或使用可用的 用于生成定制编程解决方案的核心资源。这将通过提供培训和 有关使用分析和脚本软件、在线工具和高性能的实际操作说明 耶鲁大学的计算机基础设施。核心还将根据以下需要执行特定于项目的分析 项目调查人员，包括从头组装来自RNA-Seq数据的转录本，荧光图像 蛋白质表达的定量分析，以及质谱学数据的分析。再来一次 重点放在数据管理和使用数据存档的标准和协议以及 传播。为此，核心将利用耶鲁大学现有的生物信息学资源，部署 数据管理系统。

Core B, Summary/Abstract The proposed research on molecular mechanisms of tumor virus action relies on data-intensive scientific approaches. In response, the Bioinformatics Core aims 1) at providing computational expertise and services across the projects in this program, 2) at deploying a data management solution for the storing and sharing of project-generated data and 3) at offering a forum for promoting program-specific research opportunities to a wide range of informatics trainees and faculty. A major focus is on the provision of timely bioinformatics advice and analysis and on providing instruction on the use of bioinformatics tools and/or use of available core resources for generating custom programming solutions. This will be achieved by offering training and hands-on instructions on the use of analysis and scripting software, online tools, and high-performance computing infrastructure at Yale. The Core will also be performing project-specific analyses, as needed by the project investigators, including de novo assembly of transcripts from RNA-Seq data, fluorescent image analysis for quantification of protein expression, and analysis of mass spectrometry data. A further emphasis is on data management and the use of standards and protocols for data archiving and dissemination. To this end, the Core will leverage existing bioinformatics resources at Yale for deploying a data management system.