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Integrative Biostatistics and Informatics Core

综合生物统计学和信息学核心

基本信息

批准号：
8975330
负责人：
Ivo D Dinov
金额：
$ 18.86万
依托单位：
UNIVERSITY OF MICHIGAN AT ANN ARBOR
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/8975330
关键词：
Animals Architecture Bioinformatics Biometry Clinic Clinical Clinical Research Communication Computer software Data Data Analyses Data Reporting Data Set Databases Deposition Development Ensure Experimental Designs Experimental Models Genomics Goals Health Health Insurance Portability and Accountability Act Health Services Accessibility Human Human Resources Informatics Institutes Knowledge Link Medicine Methodology Michigan Mining Molecular Obesity Phenotype Proteomics Research Research Infrastructure Research Personnel Research Support Resources Secure Services Software Tools Source Statistical Data Interpretation Technology Training Translational Research Weight maintenance regimen Work analytical tool base bench to bedside clinically relevant data acquisition data format data management data mining data visualization design experience innovation metabolomics molecular phenotype neurobehavioral nutrition pre-clinical research programs prospective research study technology/technique tool transcriptomics

项目摘要

The Integrative Biostatistics and Informatics Core (IBIC) will provide expertise in experimental design, data management and analysis for preclinical, clinical and translational research studies conducted by MNORC Research Base investigators. Core will focus on providing assistance in data base design that can accept multiple data types, including molecular phenotypes derived from multiple ‘omics technologies. The latter will require proper data architecture and tools to integrate and visualize data. The IBIC will assure that all clinically relevant databases will be Health Insurance Portability and Accountability Act (HIPAA) compliant. The IBIC will continue support for Research Base investigators with the Michigan Institute for Clinical and Health Research (MICHR), the Department of Computational Medicine and Bioinformatics (DCMB) and the BRCF Bioinformatics Core, to provide additional biostatistics and informatics services. The Core will also continue to develop new tools for data mining of relevant databases as well as assistance and training in the use of various software, Cloud and service tools for analysis of genomic, transcriptomic, metabolomic and proteomic data. Finally, IBIC personnel will collaborate with other Cores and the Weight Management Program to develop appropriate data formats and database constructs to integrate clinical, molecular, neurobehavioral and other phenotypic data into formats that ease analysis by biostatistical and informatics methodologies.

综合生物统计学和信息学核心（IBIC）将提供实验设计，数据，管理和分析由MNORC进行的临床前、临床和转化研究研究基地调查员。核心将专注于提供数据库设计方面的援助，多种数据类型，包括从多种组学技术中获得的分子表型。后者将需要适当的数据架构和工具来集成和可视化数据。IBIC将确保所有临床相关数据库将符合健康保险流通和责任法案（HIPAA）。IBIC将继续支持密歇根临床和健康研究所的研究基地研究人员（MICHR），计算医学和生物信息学系（DCMB）和BRCF生物信息学核心，提供额外的生物统计和信息学服务。核心还将继续开发新的相关数据库的数据挖掘工具以及各种软件使用方面的援助和培训，用于分析基因组、转录组、代谢组和蛋白质组数据的云和服务工具。最后，IBIC人员将与其他核心和体重管理计划合作，适当的数据格式和数据库结构，以整合临床、分子、神经行为和其他表型数据转换成便于生物统计学和信息学方法分析的格式。