Modulation of IgG blood-brain barrier permeability by surface-accessible glycan moieties
通过表面可及的聚糖部分调节 IgG 血脑屏障通透性
基本信息
- 批准号:8872573
- 负责人:
- 金额:$ 8.67万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2015
- 资助国家:美国
- 起止时间:2015-06-01 至 2017-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAlzheimer&aposs DiseaseAmyloid beta-ProteinAntibodiesBlood - brain barrier anatomyBrainCarbohydratesCentral Nervous System DiseasesClinical TrialsDetectionEnsureFaceGalactoseGlycoproteinsHumanImmuneImmunoglobulin GIn VitroInfusion proceduresIntravenous ImmunoglobulinsIodineLectinMeasuresMethodologyMethodsModelingMonoclonal AntibodiesMusNeurodegenerative DisordersOutcomePathway interactionsPatientsPenetrationPeripheralPermeabilityPharmaceutical PreparationsPolysaccharidesRadiolabeledRoleSialic AcidsSurfaceSurface Plasmon ResonanceTestingTherapeutic antibodiesTissuesTransgenic MiceWorkfunctional declinein vitro Modelpeptide Apublic health relevanceradiotracerresponsesialylationtherapeutic target
项目摘要
DESCRIPTION (provided by applicant): Here, we will test the hypothesis that IgG antibody blood-brain barrier permeability will increase in response to elevated surface sialic acid levels. Increasing the blood-brain barrier permeability of antibodies is important because antibody drugs for Alzheimer's Disease and other neurodegenerative disorders remain largely outside the brain after administration. Increasing antibody concentrations in the brain will help the antibodies access their primary therapeutic targets and may also tap into new immune pathways that benefit patients. The project consists of two aims that each address a question below: (1) Does the average IgG blood-brain barrier permeability increase upon addition of IgG sialic acid? (2) Is the blood-brain barrier permeability specific for sialylated IgG higher than fo desiaylated IgG? Both aims will use in vitro blood-brain barrier models to ensure that blood-brain barrier permeability is measured in the absence of other influx and efflux pathways. Aim 1 uses a standard radiolabelling methodology for IgG detection. Aim 2 uses a glycan-specific Surface Plasmon Resonance method to specifically track IgG with surface exposed sialic acid or galactose moieties. Support for this hypothesis will open new avenues for antibody treatment of Alzheimer's Disease and other diseases of the central nervous system.
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
WILLIAM A BANKS其他文献
WILLIAM A BANKS的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('WILLIAM A BANKS', 18)}}的其他基金
Mechanisms of Blood-brain Barrier Disruption in Type II Diabetes
II 型糖尿病血脑屏障破坏的机制
- 批准号:
9110653 - 财政年份:2016
- 资助金额:
$ 8.67万 - 项目类别:
Modulation of IgG blood-brain barrier permeability by surface-accessible glycan moieties
通过表面可及的聚糖部分调节 IgG 血脑屏障通透性
- 批准号:
9069723 - 财政年份:2015
- 资助金额:
$ 8.67万 - 项目类别:
Intranasal Insulin in a Mouse Model of Alzheimer's Disease
阿尔茨海默病小鼠模型中的鼻内胰岛素
- 批准号:
9514755 - 财政年份:2014
- 资助金额:
$ 8.67万 - 项目类别:
Intranasal Insulin in a Mouse Model of Alzheimer's Disease
阿尔茨海默病小鼠模型中的鼻内胰岛素
- 批准号:
8760193 - 财政年份:2014
- 资助金额:
$ 8.67万 - 项目类别:
Intranasal Insulin in a Mouse Model of Alzheimer's Disease
阿尔茨海默病小鼠模型中的鼻内胰岛素
- 批准号:
8919201 - 财政年份:2014
- 资助金额:
$ 8.67万 - 项目类别:
Intranasal Insulin in a Mouse Model of Alzheimer's Disease
阿尔茨海默病小鼠模型中的鼻内胰岛素
- 批准号:
9050620 - 财政年份:2014
- 资助金额:
$ 8.67万 - 项目类别:
Mitochondrial Carbonic Anhydrases and Diabetic Blood-Brain Barrier Disruption
线粒体碳酸酐酶和糖尿病血脑屏障破坏
- 批准号:
8213409 - 财政年份:2011
- 资助金额:
$ 8.67万 - 项目类别:
Mitochondrial Carbonic Anhydrases and Diabetic Blood-Brain Barrier Disruption
线粒体碳酸酐酶和糖尿病血脑屏障破坏
- 批准号:
8420518 - 财政年份:2011
- 资助金额:
$ 8.67万 - 项目类别:
Mitochondrial Carbonic Anhydrases and Diabetic Blood-Brain Barrier Disruption
线粒体碳酸酐酶和糖尿病血脑屏障破坏
- 批准号:
8604388 - 财政年份:2011
- 资助金额:
$ 8.67万 - 项目类别:
Mitochondrial Carbonic Anhydrases and Diabetic Blood-Brain Barrier Disruption
线粒体碳酸酐酶和糖尿病血脑屏障破坏
- 批准号:
8041786 - 财政年份:2011
- 资助金额:
$ 8.67万 - 项目类别:














{{item.name}}会员




