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Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity

Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity
控制中枢神经系统药物输送：调节 P-糖蛋白活性
批准号：
8195881
负责人：
WILLIAM A BANKS
金额：
$0.0万
依托单位：
ST. LOUIS VA MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
项目状态：
已结题
起止时间：
2009-04-01 至 2013-03-31
来源：
https://reporter.nih.gov/project-details/8195881
关键词：
Adverse effectsAffectAffinityAlzheimer&aposs DiseaseAnalgesicsAnimalsAntibodiesArginineBloodBlood - brain barrier anatomyBrainBreedingCanis familiarisCell ExtractsCell WallCentral Nervous System AgentsCentral Nervous System DiseasesClinicalDiabetes MellitusDiseaseDoseDrug Delivery SystemsDrug EffluxDrug KineticsDrug usageEndothelial CellsEndothelin A ReceptorEndothelin-1EventGoalsHealthcareHourHumanImmune systemIn VitroIsoenzymesIvermectinKnock-outKnockout MiceLaboratoriesLeadLearningLigandsLipopolysaccharidesLiteratureLong-Term EffectsMalignant neoplasm of brainMalignant neoplasm of central nervous systemMeSH ThesaurusMeasuresMediatingMessenger RNAMethodsModelingMulti-Drug ResistanceMusNG-Nitroarginine Methyl EsterNeuraxisNeuronsNeurotoxinsNitric OxideNitric Oxide SynthaseNitric Oxide Synthase Type IObesityP-GlycoproteinPathway interactionsPerfusionPharmaceutical PreparationsPharmacogenomicsPrincipal InvestigatorProductionProgram DescriptionProteinsPumpResearchRheumatoid ArthritisRoleSeizuresSepsisSideStrokeSurfaceTherapeuticTimeToxic effectToxinTumor Necrosis Factor-alphaVerapamilVeteransWestern BlottingWorkcytokinedrug developmentefflux pumphuman NOS2A proteinhuman NOS3 proteinhuman TNFRSF1A proteinimprovedin vitro Modelin vivoinhibitor/antagonistjun OncogenemRNA Expressionpreventprogramsprotein expressionpublic health relevancereceptorresearch and developmentresponsetumor necrosis factor alpha receptoruptake

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