Control of Drug Delivery to the CNS: Modulating P-glycoprotein Activity

控制中枢神经系统药物输送：调节 P-糖蛋白活性

• 批准号: 8195881
• 负责人: WILLIAM A BANKS
• 金额: --
• 依托单位: ST. LOUIS VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2013-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8195881
• 关键词: Adverse effects; Affect; Affinity; Alzheimer' s Disease; Analgesics; Animals; Antibodies; Arginine; Blood; Blood - brain barrier anatomy; Brain; Breeding; Canis familiaris; Cell Extracts; Cell Wall; Central Nervous System Agents; Central Nervous System Diseases; Clinical; Diabetes Mellitus; Disease; Dose; Drug Delivery Systems; Drug Efflux; Drug Kinetics; Drug usage; Endothelial Cells; Endothelin A Receptor; Endothelin-1; Event; Goals; Healthcare; Hour; Human; Immune system; In Vitro; Isoenzymes; Ivermectin; Knock-out; Knockout Mice; Laboratories; Lead; Learning; Ligands; Lipopolysaccharides; Literature; Long-Term Effects; Malignant neoplasm of brain; Malignant neoplasm of central nervous system; MeSH Thesaurus; Measures; Mediating; Messenger RNA; Methods; Modeling; Multi-Drug Resistance; Mus; NG-Nitroarginine Methyl Ester; Neuraxis; Neurons; Neurotoxins; Nitric Oxide; Nitric Oxide Synthase; Nitric Oxide Synthase Type I; Obesity; P-Glycoprotein; Pathway interactions; Perfusion; Pharmaceutical Preparations; Pharmacogenomics; Principal Investigator; Production; Program Description; Proteins; Pump; Research; Rheumatoid Arthritis; Role; Seizures; Sepsis; Side; Stroke; Surface; Therapeutic; Time; Toxic effect; Toxin; Tumor Necrosis Factor-alpha; Verapamil; Veterans; Western Blotting; Work; cytokine; drug development; efflux pump; human NOS2A protein; human NOS3 protein; human TNFRSF1A protein; improved; in vitro Model; in vivo; inhibitor/antagonist; jun Oncogene; mRNA Expression; prevent; programs; protein expression; public health relevance; receptor; research and development; response; tumor necrosis factor alpha receptor; uptake