Lipoteichoic acid mediated immune modulation of chronic pain
Lipoteichoic acid mediated immune modulation of chronic pain
批准号:
9177358
负责人:
PRAVEEN THUMBIKAT
金额:
$35.19万
依托单位国家:
美国
项目类别:
财政年份:
2016
资助国家:
美国
项目状态:
已结题
起止时间:
2016-08-01 至 2020-07-31
关键词:
AccountingAmericanAnogenital regionAntigen-Presenting CellsAntigensAttenuatedAutoimmune ProcessBacteriaBiological AssayBone MarrowCD4 Positive T LymphocytesCalcium SignalingCategoriesCell WallCellsCharacteristicsChronicChronic ProstatitisClinicalCoupledDevelopmentDiagnosisDiseaseDysuriaEscherichia coliEtiologyFutureGoldHDL receptorHigh Density LipoproteinsHumanHuman VolunteersIL2RA geneImmuneImmune responseImmunityImmunosuppressionIn VitroInfectionInjuryInterleukin-10IntestinesLeadLifeLigandsMediatingMediator of activation proteinModelingMolecularMorbidity - disease rateMusNamesNatureNeural PathwaysNeuronsNociceptionOutpatientsPDCD1LG1 genePainParentsPatientsPelvic PainPeripheral Blood Mononuclear CellPrimary Care PhysicianProstateRegulatory T-LymphocyteReportingRoleSelf ToleranceSignal TransductionSourceStaphylococcus epidermidisSyndromeT-LymphocyteTLR2 geneTestingTestisTherapeuticUnited StatesVisitattenuationbasechronic painchronic pelvic paincommensal microbesimmune activationimmunoregulationin vitro testingin vivolipoteichoic acidmacrophagemast cellmenmicrobialmonocytemouse modelnanoparticlenovelpathogenpenisprostatitisreconstitutionresponsescavenger receptortargeted treatment
中文摘要
总结
英文摘要
Summary
Prostatitis accounts for 2 million outpatient visits per year in the United States, including 1% of those to primary
care physicians. Chronic pelvic pain syndrome (CPPS) is clinically characterized by dysuria and pain in the
perineum, testes, penis and suprapubic region. CPPS accounts for 90% of all chronic prostatitis but the
initiating factors that establish the syndrome are unknown. We hypothesized that bacterial isolates from the
prostate, particularly long--‐lived clinical strains and resident commensals, are capable of influencing prostate
immunity. When mice with non--‐infectious autoimmune prostatitis (Experimental autoimmune prostatitis -
EAP), were instilled with the commensal S. epidermidis, there was a rapid amelioration of pelvic pain and a
negative modulation of the pathogenic immune response in the prostate. These results lead us to hypothesize
that S. epidermidis LTA (SELTA) induces expression of co--‐stimulatory ligands to inhibit effector T cells,
activate regulatory T cells and abrogate mast cell degranulation, resulting in the amelioration of pelvic pain. We
therefore propose the following specific aims: 1. Identifying the mechanism of pain attenuation mediated by S.
epidermidis LTA. 2. Defining the role of TLR’s in SELTA--‐mediated immune modulation. 3. Evaluating SELTA
conjugatedHDL--‐goldnanoparticles as a therapeutic for pelvic pain. The proposed studies will provide a
mechanistic understanding of how SELTA inhibits pelvic pain and will develop novel cutting--‐edge
therapeutics for testing in human CP/CPPS.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Effects of Epigenetic Regulation in Chronic Pelvic Pain Syndrome
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批准号:10264094
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项目类别:
-
资助金额:$24.0万
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财政年份:2020
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Effects of Epigenetic Regulation in Chronic Pelvic Pain Syndrome
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批准号:10448336
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项目类别:
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资助金额:$24.0万
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财政年份:2020
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Lipoteichoic acid mediated modulation of chronic pain
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批准号:10539502
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项目类别:
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资助金额:$54.07万
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财政年份:2016
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Lipoteichoic acid mediated modulation of chronic pain
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批准号:10688082
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项目类别:
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资助金额:$54.07万
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财政年份:2016
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负责人:PRAVEEN THUMBIKAT
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依托单位:
T cells in Chronic Pelvic Pain
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批准号:8789163
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项目类别:
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资助金额:$33.6万
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财政年份:2013
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负责人:PRAVEEN THUMBIKAT
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依托单位:
T cells in Chronic Pelvic Pain
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批准号:8438510
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项目类别:
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资助金额:$33.6万
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财政年份:2013
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负责人:PRAVEEN THUMBIKAT
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依托单位:
T cells in Chronic Pelvic Pain
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批准号:8635347
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项目类别:
-
资助金额:$33.6万
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财政年份:2013
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Mast cells in male pelvic pain and lower urinary tract dysfunction
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批准号:9303340
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项目类别:
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资助金额:$34.76万
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财政年份:2010
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Chemokine Mechanisms in Chronic Pelvic Pain
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批准号:8141242
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项目类别:
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资助金额:$31.75万
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财政年份:2010
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Chemokine Mechanisms in Chronic Pelvic Pain
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批准号:7988059
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项目类别:
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资助金额:$39.91万
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财政年份:2010
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Chemokine Mechanisms in Chronic Pelvic Pain
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批准号:8321899
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项目类别:
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资助金额:$31.77万
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财政年份:2010
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Chemokine Mechanisms in Chronic Pelvic Pain
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批准号:8703080
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项目类别:
-
资助金额:$31.77万
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财政年份:2010
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Chemokine Mechanisms in Chronic Pelvic Pain
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批准号:8511613
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项目类别:
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资助金额:$30.66万
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财政年份:2010
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Role of Pattern Recognition Receptors in Prostate Epithelial Inflammation
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批准号:8435436
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项目类别:
-
资助金额:$10.58万
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财政年份:2009
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Role of Pattern Recognition Receptors in Prostate Epithelial Inflammation
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批准号:8051570
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项目类别:
-
资助金额:$10.58万
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财政年份:2009
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Role of Pattern Recognition Receptors in Prostate Epithelial Inflammation
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批准号:7588277
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项目类别:
-
资助金额:$10.13万
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财政年份:2009
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Role of Pattern Recognition Receptors in Prostate Epithelial Inflammation
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批准号:7760141
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项目类别:
-
资助金额:$10.35万
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财政年份:2009
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负责人:PRAVEEN THUMBIKAT
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依托单位:
Role of Pattern Recognition Receptors in Prostate Epithelial Inflammation
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批准号:8230732
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项目类别:
-
资助金额:$10.58万
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财政年份:2009
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负责人:PRAVEEN THUMBIKAT
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依托单位:
海外基金