REPRODUCTIVE ASSESSMENTS BY CONTINUOIUS BREEDING (RACB)

连续育种繁殖评估 (RACB)

• 批准号: 9200931
• 负责人: TIMOTHY FENNELL
• 金额: $ 3.11万
• 依托单位: RESEARCH TRIANGLE INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2016-06-15
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9200931
• 关键词: Adolescent; Adult; Affect; Birth; Breeding; Chemicals; Chemistry; Congenital Abnormality; Contracts; Development; Diet; Dose; Epididymis; Evaluation; Exposure to; Fetal Development; Fetal Weight; Generations; Growth; Hazard Identification; Health; Infertility; Laboratory Animals; Mus; Organ; Ovary; Perinatal; Perinatal Exposure; Pregnancy; Production; Protocols documentation; Puberty; Rattus; Research; Research Design; Testing; Testis; Time; Toxic effect; Toxicology; Uterus; body system; critical period; design; drinking water; environmental chemical; fetal; in utero; innovation; offspring; programs; reproductive; reproductive organ; reproductive toxicity; response

This program is designed to evaluate the potential for environmental chemicals to adversely affect health due to exposures that occur during the perinatal period including fetal and juvenile exposure. Rats are exposed to environmental chemicals in utero during fetal development and exposures continue after birth and into adulthood. Endpoints evaluated include pregnancy status, maternal and fetal body weights, evaluations for birth defects, growth of offspring, timing of puberty, evaluations for birth defects, evaluations for infertility and reproductive problems, and organ toxicity, especially as it relates to reproductive organs including ovary, uterus, testes and epididymides. The contract evaluates toxicity of selected chemicals in rats and mice using dietary, gavage, or drinking water administration. The contract includes performing prestart chemistry activities, ranging finding studies and multi-generation reproductive toxicity studies including modified one-generation studies in laboratory animals.

该计划旨在评估环境化学品因围产期暴露（包括胎儿和青少年暴露）而对健康产生不利影响的可能性。 大鼠在胎儿发育期间在子宫内暴露于环境化学品，并在出生后持续暴露至成年。 评价的终点包括妊娠状态、母体和胎儿体重、出生缺陷评价、后代生长、青春期时间、出生缺陷评价、不孕症和生殖问题评价以及器官毒性，尤其是涉及生殖器官（包括卵巢、子宫、睾丸和附睾）时。 该合同通过饮食、灌胃或饮用水给药，评估选定化学品对大鼠和小鼠的毒性。 该合同包括执行启动前化学活动，范围发现研究和多代生殖毒性研究，包括在实验室动物中修改的一代研究。