North Carolina Hepatitis B Research Network

 描述(由申请人提供)：乙肝研究网络(HBRN)成立于2008年，是一个研究乙肝疾病新方面的临床和翻译研究人员联盟。HBRN的重点是进一步阐明美国慢性乙肝的自然历史，并在免疫活跃(IA)和免疫耐受(IT)人群中进行临床试验，比较单一疗法和联合疗法。利用成人队列研究的基线数据进行了许多流行病学研究，几项研究已经出版或提交出版。同样，辅助研究将进一步加深我们对乙肝发病机制的理解，利用 与生物检疫有关的强有力的临床数据已经启动。这份续签申请将侧重于继续HBRN的非凡努力，详细说明北卡罗来纳州乙肝研究联盟在这一努力中的不可或缺的作用，并提出有助于了解乙肝发病机制的新颖翻译研究。

 DESCRIPTION (provided by applicant): The Hepatitis B Research Network (HBRN) was established in 2008 as a consortium of clinical and translational investigators studying novel aspects of hepatitis B disease. The focus of the HBRN has been to further elucidate the natural history of chronic hepatitis B in the United States and to conduct clinical trials comparing monotherapy versus combination therapy in immuneactive (IA) and immunetolerant (IT) populations. Numerous epidemiological studies utilizing the baseline data from the Adult Cohort Study have been implemented and several have been published or submitted for publication. Similarly, ancillary studies that will further our understanding of HBV pathogenesis, utilizing the robust clinical data linked with biospecimens, have been initiated. This renewal application will focus on continuing the extraordinary efforts of the HBRN, detail the integral role of The North Carolina Hepatitis B Research Consortium in this endeavor, and propose novel translational studies that will contribute to understanding HBV pathogenesis.