North Carolina Hepatitis B Research Network

北卡罗来纳州乙型肝炎研究网络

• 批准号: 9352985
• 负责人: MICHAEL W FRIED
• 金额: $ 6.36万
• 依托单位: UNIV OF NORTH CAROLINA CHAPEL HILL
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9352985
• 关键词: Academic Medical Centers; Adult; Age; Ancillary Study; Anti-Inflammatory Agents; Anti-inflammatory; Characteristics; Childhood; Chronic Hepatitis B; Cirrhosis; Clinical; Clinical Data; Clinical Trials; Cohort Studies; Combined Modality Therapy; Comorbidity; Conduct Clinical Trials; Control Groups; Data; Development; Disease; Eicosanoids; Enrollment; Epidemiologic Studies; Etiology; Exposure to; Family; Flare; Fostering; Gender; Geographic Locations; Goals; Health; Hepatitis B; Hepatitis B Surface Antigens; Hepatitis B Virus; Hepatitis B e Antigens; Hepatitis E; Immune; Immune Tolerance; Immune response; Immunoglobulin G; Immunoglobulin M; Infection; Inflammation; Leadership; Link; Lipid Peroxidation; Lipids; Liver; Liver Failure; Liver diseases; Measures; Methods; Molecular Profiling; Natural History; North America; North Carolina; Participant; Pathogenesis; Patients; Phase; Pilot Projects; Play; Population; Prevalence; Primary carcinoma of the liver cells; Publications; Publishing; RNA; Race; Regulation; Research; Research Personnel; Role; Sampling; Serological; Serum; Testing; Transaminases; United States; Universities; Viral; Viremia; Writing; co-infection; cohort; experience; follow-up; global health; innovation; lipid mediator; liver injury; member; novel; pathogen; research study; response; seroconversion; success; translational study; trial comparing

 DESCRIPTION (provided by applicant): The Hepatitis B Research Network (HBRN) was established in 2008 as a consortium of clinical and translational investigators studying novel aspects of hepatitis B disease. The focus of the HBRN has been to further elucidate the natural history of chronic hepatitis B in the United States and to conduct clinical trials comparing monotherapy versus combination therapy in immuneactive (IA) and immunetolerant (IT) populations. Numerous epidemiological studies utilizing the baseline data from the Adult Cohort Study have been implemented and several have been published or submitted for publication. Similarly, ancillary studies that will further our understanding of HBV pathogenesis, utilizing the robust clinical data linked with biospecimens, have been initiated. This renewal application will focus on continuing the extraordinary efforts of the HBRN, detail the integral role of The North Carolina Hepatitis B Research Consortium in this endeavor, and propose novel translational studies that will contribute to understanding HBV pathogenesis.

 描述（由申请人提供）：乙型肝炎研究网络 (HBRN) 成立于 2008 年，是一个由临床和转化研究人员组成的联盟，研究乙型肝炎疾病的新方面。 HBRN 的重点是进一步阐明美国慢性乙型肝炎的自然史，并在免疫活性 (IA) 和免疫耐受 (IT) 人群中进行比较单一疗法与联合疗法的临床试验。利用成人队列研究的基线数据进行了大量流行病学研究，其中一些研究已经发表或提交发表。同样，辅助研究将进一步加深我们对 HBV 发病机制的了解，利用 与生物样本相关的可靠临床数据已经启动。该更新申请将重点关注继续 HBRN 的非凡努力，详细介绍北卡罗来纳州乙型肝炎研究联盟在这一努力中的不可或缺的作用，并提出有助于了解 HBV 发病机制的新颖转化研究。