Pathophysiology-Guided Therapy for Sleep Apnea in the Elderly

老年人睡眠呼吸暂停的病理生理学引导治疗

• 批准号: 9105161
• 负责人: Susmita Chowdhuri
• 金额: --
• 依托单位: JOHN D DINGELL VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9105161
• 关键词: Acetazolamide; Adherence; Age; Alternative Therapies; Apnea; Area; Breathing; Carbon Dioxide; Cardiovascular system; Central Sleep Apnea; Chemoreceptors; Development; Devices; Elderly; Elderly man; Elderly woman; Environmental air flow; Finasteride; Functional disorder; Goals; Health; High Prevalence; Hypercapnia; Hyperoxia; Intervention; K-Series Research Career Programs; Life; Measures; Modality; Morbidity - disease rate; Neurocognitive; Oral; Oxygen; Pathway interactions; Physiological; Plants; Polysomnography; Population; Prevalence; Quality of life; Research; Sleep; Sleep Apnea Syndromes; Syndrome; Testosterone; Therapeutic; Veterans; age group; cerebrovascular; effective therapy; improved; innovation; male; middle age; mortality; novel; novel therapeutic intervention; personalized medicine; pressure; public health relevance; research study; targeted treatment; trait

 DESCRIPTION (provided by applicant): Sleep apnea-hypopnea syndrome (SAHS) has a high prevalence and is associated with adverse cardiovascular consequences in elderly veterans. Positive airway pressure therapy is deemed cumbersome and often associated with non-adherence to therapy. This proposal will investigate whether alternative therapies can be developed by modulating specific physiologic mechanisms of ventilatory control including chemoresponsiveness and cerebrovascular responsiveness. Specifically, we will study whether interventions with sustained hyperoxia (Aim 1), finasteride (Aim 2) and acetazolamide (Aim 3) will reduce breathing instability during sleep by reducing chemoresponsiveness and/or increasing cerebrovascular reactivity in order to alleviate sleep disordered breathing in elderly veterans with sleep apnea. The proposed aims will also allow us to delineate key mechanisms of breathing instability in the elderly. We envision that the results obtained from this project will ultimately allow us to develop novel alternative therapies for sleep apnea in elderly veterans.

 描述（由申请人提供）： 睡眠呼吸暂停低通气综合征（SAHS）的患病率很高，并且与老年退伍军人的不良心血管后果有关。气道正压通气治疗被认为很麻烦，并且通常与不坚持治疗有关。该提案将研究是否可以通过调节通气控制的特定生理机制（包括化学反应性和脑血管反应性）来开发替代疗法。具体来说，我们将研究持续高氧（目标 1）、非那雄胺（目标 2）和乙酰唑胺（目标 3）的干预措施是否会通过减少化学反应和/或增加脑血管反应性来减少睡眠期间的呼吸不稳定性，从而缓解患有睡眠呼吸暂停的老年退伍军人的睡眠呼吸障碍。拟议的目标还将使我们能够描绘老年人呼吸不稳定的关键机制。我们设想 该项目获得的结果最终将使我们能够开发出治疗老年退伍军人睡眠呼吸暂停的新型替代疗法。