Predictors of Post-COVID Clinical and Cognitive Consequences

新冠疫情后临床和认知后果的预测因素

• 批准号: 10589434
• 负责人: Susmita Chowdhuri
• 金额: --
• 依托单位: JOHN D DINGELL VA MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-12-01 至 2024-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10589434
• 关键词: Acute; Adverse effects; Alleles; Alzheimer' s disease patient; Apolipoprotein E; Area; Blood Coagulation Disorders; COVID-19; COVID-19 complications; COVID-19 cytokine storm; COVID-19 impact; COVID-19 severity; COVID-19 survivors; Chronic; Clinical; Cognitive; Cognitive deficits; Complex; Coughing; Data; Development; Diagnostic; Disease; Dyspnea; Encephalopathies; Fatigue; Functional disorder; Future; Genes; Goals; Headache; Health; Healthcare; Hour; Hypoxia; Impaired cognition; Impairment; Incidence; Infection; Inflammation; Interleukin-6; Knowledge; Link; Long COVID; Long-Term Effects; Memory impairment; Mental Health; Neurocognitive; Neurocognitive Deficit; Neurologic; Neutrophilia; Observational Study; Obstructive Sleep Apnea; Pathway interactions; Patients; Pilot Projects; Post-Acute Sequelae of SARS-CoV-2 Infection; Quality of life; Recovery; Recovery of Function; Rehabilitation therapy; Reporting; Research; Respiratory Signs and Symptoms; Risk; SARS-CoV-2 infection; Severities; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Sleep Fragmentations; Sleep disturbances; Symptoms; TNF gene; Testing; Therapeutic; Veterans; Virus; Visit; acute infection; brain fog; cognitive function; coronavirus disease; cytokine; disability; improved; inflammatory marker; novel; physical conditioning; physical symptom; poor sleep; post SARS-CoV-2 infection; post-COVID-19; prospective; research study; respiratory; response; severe COVID-19; sleep quality; therapeutic target; trait

Patients recovering from acute COVID-19 infection often suffer from a multitude of debilitating chronic physical symptoms that can last up to 6 months or more. The incidence of fatigue, cognitive impairment and respiratory symptoms are reported to be very high in the post-COVID period. The underlying pathophysiology of cognitive impairment is unclear in these patients. Notably, sleep disturbances are common during this post-COVID period, and sleep apnea has been associated with an increased risk for severe COVID infection. Thus, it is conceivable that sleep fragmentation, per se, may confer an increased risk for chronic cognitive deficits in Veterans post-COVID. Our proposed pilot project will determine if there is a link between post-COVID sleep disturbances, sleep apnea and cognitive function. Knowledge gained from our examinations may guide development of novel management pathways, i.e., mitigation of sleep disturbances may present a therapeutic strategy for alleviating chronic post-COVID cognitive impairment. Aim1 will investigate the effect of sleep duration and sleep quality on neurocognitive function in post-COVID Veterans. Aim 2 will study whether the severity of OSA determines neurocognitive function Veterans who are post-COVID. This is an observational study where we will gather retrospective as well as prospective data on the long-term effects of COVID on neurocognitive function and sleep. Our long-term goal is to enhance rehabilitation and recovery of function of Veterans suffering from post-COVID consequences that may arise due to sleep disturbances, with the ultimate objective of improving the overall health and quality of life of Veterans recovering from COVID-19 infection.

从急性COVID-19感染中恢复的患者通常会遭受多种使人衰弱的慢性身体疾病， 症状可能持续6个月或更长时间。疲劳、认知障碍和呼吸系统疾病的发生率 据报道，在COVID后时期，症状非常严重。认知障碍的潜在病理生理学 这些患者的损伤尚不清楚。值得注意的是，在新冠肺炎后的这段时间里， 睡眠呼吸暂停与严重COVID感染的风险增加有关。照经上所 可以想象，睡眠碎片本身可能会增加慢性认知缺陷的风险， 新冠肺炎后的退伍军人。我们提议的试点项目将确定新冠肺炎后的睡眠是否与 睡眠呼吸暂停和认知功能。从我们的考试中获得的知识可以指导 开发新的管理途径，即，缓解睡眠障碍可能是一种治疗方法， 缓解COVID后慢性认知障碍的策略。 Aim 1将研究睡眠时间和睡眠质量对COVID后神经认知功能的影响 老兵目的2将研究OSA的严重程度是否决定神经认知功能。 新冠肺炎后这是一项观察性研究，我们将收集回顾性和前瞻性数据， 新冠肺炎对神经认知功能和睡眠的长期影响。我们的长期目标是提高 康复和恢复可能出现的COVID后后果的退伍军人的功能 由于睡眠障碍，最终目标是改善整体健康和生活质量， 从COVID-19感染中康复的退伍军人。