Comp C-Eval of Best Urologic Management for Newborns with SB

Comp C-SB 新生儿最佳泌尿外科管理的评估

• 批准号: 9108702
• 负责人: William Otis Walker
• 金额: $ 2.05万
• 依托单位: SEATTLE CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-09-01 至 2019-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9108702
• 关键词: Comp; Eval; Best; Urologic; Management

DESCRIPTION (provided by applicant): Spina bifida (SB) is a serious birth defect, and is the most common of the neural tube defects (NTDs). Infants who have myelomeningocele (MM), a type of SB, often have bladder problems resulting from their SB. These problems, if not managed properly, can lead to serious kidney damage. A new protocol for bladder management for children with SB has been developed. This proposal is to evaluate the effectiveness of the bladder management protocol in newborn infants with myelomeningocele. The objectives of this project are: 1) To implement this protocol at for all newborns with MM receiving inpatient care at SCH, 2) To evaluate the effectiveness of the protocol in preventing bladder and kidney problems in the first five years of life. Newborn infants who are receiving inpatient care at SCH for myelomeningocele and have not been hospitalized before will be eligible to participate. Data will be collected for each participant at their follow up visits, using data recorded in the hospitl electronic and paper medical record. Information about the child's diagnosis, treatment, and health outcomes will be collected. Data analysis will be guided by the study coordinating committee, and will be to identify how well the protocol was implemented and how often children develop kidney and bladder problems.

描述（由申请人提供）：脊柱裂（SB）是一种严重的出生缺陷，是最常见的神经管缺陷（NTDs）。患有脊髓脊膜膨出（MM）（SB的一种）的婴儿通常会因SB而出现膀胱问题。这些问题如果处理不当，可能导致严重的肾脏损伤。一个新的协议膀胱管理的儿童SB已经制定。此建议是为了评估膀胱管理协议在新生儿脊髓脊膜膨出的有效性。本项目的目的是：1）对所有在SCH接受住院治疗的MM新生儿实施本方案，2）评价本方案在预防出生后前五年膀胱和肾脏问题方面的有效性。因脊髓脊膜膨出在SCH接受住院治疗且之前未住院的新生儿将有资格参与。将使用医院电子和纸质病历中记录的数据，在随访访视时收集每例受试者的数据。将收集有关儿童诊断、治疗和健康结果的信息。数据分析将由研究协调委员会指导，并将确定该方案的实施情况以及儿童发生肾脏和膀胱问题的频率。