Signaling Pathways in Innate Immunity

描述(由申请人提供)：在过去的15年里，现代免疫学在天然免疫领域的知识发生了前所未有的扩展。“先天免疫中的信号通路”(SPII)培训计划代表了一个修订的、新的T32应用程序，以支持这一重要和新兴领域的2名博士后和2名博士后学员。马里兰大学医学院(UMSOM)在这一领域拥有强大的研究和培训实力。这一独特且高度集中的项目的培训资助学院(TGF)主要来自微生物学和免疫学系以及UMSOM的几个跨学科中心和研究所，包括粘膜生物学研究中心、血管和炎症性疾病中心、疫苗开发中心、Greenebaum癌症中心和人类病毒学研究所。除了一家外，其余的学校都位于密歇根大学微生物学与免疫学系2个街区的范围内。信托基金在赠款和出版物方面有着长期的合作历史，资金充足，赠款和合同每年的直接成本总额约为1740万美元。博士前实习生将主要来自分子微生物学和免疫学(MMI)和分子医学(MM)的跨部门生命科学研究生计划(GPILS)，这些计划包括共同核心课程、特定于计划的课程、选修课程、期刊俱乐部、研讨会、年度研讨会和研究生研究报告日。额外的学术工作将与严格的实验室培训相结合，通过实验室轮换和论文研究，在转化生长因子的指导下，其文件记录的专门知识将提供跨学科和多学科的培训机会。博士前学生是从越来越合格的申请者中挑选出来的，也是从UMSOM医学博士/博士项目中挑选出来的。同样，我们的培训助学金合格的博士后学员越来越多地被拥有先天免疫信号专业知识的实验室所吸引。博士后和博士后实习生都将有额外的授课和非授课要求，包括负责任的研究和专业发展方面的培训，以及高度结构化的指导计划。已经作出了具体努力，从代表性不足的少数群体中招募受训人员。该计划由一支高素质的团队指导，其中包括培训计划主任、两名联席主任、一个指导委员会和一个由国际公认的天然免疫专家组成的外部咨询委员会。我们预计，我们的实习生将会非常出色 为未来在学术界、政府和行业的职业生涯做好准备，并将以重大方式为这一复杂的先天免疫领域的基本和翻译问题做出贡献。

DESCRIPTION (provided by applicant): An unprecedented expansion of knowledge has occurred in modern immunology in the field of innate immunity over the last 15 years. The "Signaling Pathways in Innate Immunity" (SPII) Training Program represents a revised, new T32 application to support 2 predoctoral and 2 postdoctoral trainees in this important and burgeoning area. The University of Maryland, School of Medicine (UMSOM) has significant research and training strengths in this area. The Training Grant Faculty (TGF) for this unique and highly focused program are drawn primarily from the Department of Microbiology and Immunology and several interdisciplinary centers and institutes at UMSOM including the Mucosal Biology Research Center, the Center for Vascular and Inflammatory Diseases, the Center for Vaccine Development, Greenebaum Cancer Center, and the Institute of Human Virology. All but one TGF are located within a 2-block distance of the Department of Microbiology & Immunology on the UMSOM campus. The TGF have a longstanding history of collaboration on grants and publications, and are well funded, with grants and contracts totaling ~$17.4 million in annual direct costs. Predoctoral trainees will be drawn primarily from the interdepartmental Graduate Program in Life Sciences (GPILS) Programs in Molecular Microbiology & Immunology (MMI) and Molecular Medicine (MM), established Ph.D. Programs that include a common core curriculum, program-specific courses, elective courses, journal clubs, seminars, annual symposia, and graduate research presentation days. Additional academic work will be combined with rigorous laboratory training through laboratory rotations and dissertation research under the direction of the TGF whose documented expertise will provide inter- and multidisciplinary training opportunities. Predoctoral students are selected from an increasingly qualified applicant pool, as well as from the UMSOM M.D./Ph.D. Program. Similarly, our Training Grant Eligible postdoctoral trainees are increasingly gravitating to laboratories with expertise in innate immune signaling. Both pre- and postdoctoral trainees will have additional didactic and non-didactic requirements, including training in the responsible conduct of research and professional development, as well as a highly structured mentoring program. Specific efforts are already in place to recruit trainees from underrepresented minorities. The program is guided by a highly qualified team including the Training Program Director, two Co-Directors, a Steering Committee, and an External Advisory Committee comprised of internationally recognized experts in innate immunity. We anticipate that our trainees will be extraordinarily well prepared for future careers in academia, government, and industry and will contribute in significant ways to basic and translational problems in this complex area of innate immunity.