Enhanced STI/HIV Partner Notification in South Africa

南非加强性传播感染/艾滋病毒合作伙伴通知

• 批准号: 8798679
• 负责人: SETH C KALICHMAN
• 金额: $ 59.81万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2016-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8798679
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Affect; Africa South of the Sahara; African; Age; Area; Attention; Behavioral; Blood Circulation; CD4 Positive T Lymphocytes; Cells; Cessation of life; Cities; Clinic; Clinic Visits; Communication; Contracts; Counseling; Diagnosis; Diagnostic; Education; Epidemic; Event; Exercise; Exposure to; HIV; HIV Infections; HIV Seropositivity; HIV risk; Health; Health behavior change; Helper-Inducer T-Lymphocyte; Home environment; Immune; Infection; Intervention; Intervention Trial; Investigation; Laboratories; Life; Measures; Mediating; Mediation; Modeling; Notification; Outcome; Participant; Partner Communications; Partner Notification; Patients; Population; Prevalence; Preventive Intervention; Provider; Randomized; Randomized Clinical Trials; Recruitment Activity; Research; Research Design; Resources; Risk; Risk Reduction; Services; Sexual Partners; Sexually Transmitted Diseases; South Africa; Southern Africa; Testing; Time; Woman; arm; base; co-infection; communication behavior; condoms; evidence base; follow-up; high risk; improved; indexing; innovation; intervention effect; macrophage; men; post intervention; prevent; primary outcome; protective behavior; randomized trial; secondary outcome; sex risk; skills; skills training; social cognitive theory; theories; transmission process

DESCRIPTION (provided by applicant): This 5-year study will conduct a randomized clinical trial of a culturally tailored theory-based behavioral risk reduction and enhanced partner notification intervention for men and women who are receiving sexually transmitted infection (STI) diagnostic and treatment services in South Africa. Among the world's most severe HIV epidemics, as many as one in five South Africans living in the most affected areas are HIV positive. The experimental intervention in this study is grounded in social-cognitive theories of health behavior change and has been pre-tested in preliminary research. The intervention consists of a single 60-minute risk reduction counseling session with behavioral skills building components to enhance partner communication skills for improved partner notification. The study design includes two comparison conditions: behavioral risk reduction counseling without partner communication and notification skills enhancement, and a standard didactic health information condition. We will recruit 525 men and 525 women from a large STI clinic in Cape Town. Participants will be STI clinic patients age 18 or older who are receiving STI services. Participants will be baseline assessed and randomized to receive either (a) the 60-minute theory-based and culturally tailored risk reduction and partner communication/notification intervention; (b) a 60-minute risk reduction counseling intervention without partner communication/notification components; or (c) a time and contact matched 60-minute standard didactic health information session. Participants will be followed for 12 months post intervention. The study will test intervention effects on two primary endpoints: contracting new STI and objectively measured partner notification events. The randomized trial will determine the efficacy of the risk reduction intervention for South African men and women receiving STI clinic services. We will also test the mediating effects of partner notification on STI outcomes. Results of this research will therefore test a clinic-based HIV prevention intervention model that is urgently needed in South Africa.

描述（由申请人提供）：这项为期5年的研究将进行一项随机临床试验，针对南非接受性传播感染（STI）诊断和治疗服务的男性和女性进行基于文化的理论的行为风险降低和增强的伴侣通知干预。在世界上最严重的艾滋病毒流行病中，生活在受影响最严重地区的南非人中有多达五分之一是艾滋病毒阳性。本研究中的实验干预是基于健康行为改变的社会认知理论，并已在初步研究中进行了预测试。干预包括一个单一的60分钟的风险降低咨询会议与行为技能建设组件，以提高合作伙伴的沟通技巧，改善合作伙伴的通知。研究设计包括两个比较条件：行为风险降低咨询没有合作伙伴的沟通和通知技能的提高，和一个标准的教学健康信息条件。我们将从开普敦的一家大型性病诊所招募525名男性和525名女性。参与者将是18岁或以上正在接受性传播感染服务的性传播感染诊所患者。参与者将接受基线评估并随机接受（a）60分钟基于理论和文化定制的风险降低和伴侣沟通/通知干预;（B）60分钟无伴侣沟通/通知组件的风险降低咨询干预;或（c）时间和联系方式匹配的60分钟标准教学健康信息会议。参与者将在干预后随访12个月。 该研究将测试干预对两个主要终点的影响：感染新的性传播感染和客观测量的伴侣通知事件。这项随机试验将确定南非接受性传播感染诊所服务的男性和女性降低风险干预措施的有效性。我们还将测试合作伙伴通知对STI结果的中介作用。因此，这项研究的结果将测试南非迫切需要的基于诊所的艾滋病毒预防干预模式。