Assessing Xenon CT Imaging Biomarkers in Lung Transplant Recipients

评估肺移植受者的氙气 CT 成像生物标志物

基本信息

  • 批准号:
    8879139
  • 负责人:
  • 金额:
    $ 19.25万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2014
  • 资助国家:
    美国
  • 起止时间:
    2014-07-01 至 2017-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Lung transplantation is an important treatment option for patients with advanced lung diseases. Indeed, the majority of patients can expect excellent functional recovery and improved quality-of-life after transplant. Despite this improvement in early survival and function, though, obliterative bronchiolitis (OB), a generally progressive loss of small airway function, gravely threatens the long-term outlook for lung transplant recipients (LTRs). OB and its clinical correlate, bronchiolitis obliterans syndrome (BOS), is the most common chronic complication, affecting the majority of patients who survive 5 years after transplantation. The key clinical feature of BOS is the development of airway obstruction diagnosed with pulmonary function testing (PFT). However, PFT is a global lung function measure and does not provide information about regional disease involvement or early BOS. To prevent or delay onset of BOS, it would be useful to directly assess local regional development of OB. The regional OB map would allow us to evaluate mechanisms of BOS, disease progression, and provide a tool for image-guided biopsy or treatment at specific lung regions to improve the efficacy of an early therapeutic intervention. Conventional CT or MR imaging is limited, however, and does not allow a simultaneous evaluation of the regional ventilation and morphologic changes associated with early changes in BOS. Thus, we have developed a novel xenon CT regional ventilation imaging technique and quantitative method for lung morphology analysis, and propose that these new tools are crucial to investigate both functional and morphological changes in transplanted lungs and the underlying mechanisms involved in development and progression of allograft dysfunction in LTRs. The primary objective is to evaluate our xenon CT imaging technique to assess regional ventilation and morphological changes, and to associate these changes with pulmonary function testing and BOS progression. The proposed research is innovative in that we have developed a novel xenon CT lung imaging technique and a new, efficient and reliable semi-automated interactive method for segmentation. Our central hypothesis is that xenon CT can be used to quantify changes in lung regional ventilation and morphology and associate these changes with pulmonary function and disease progression. The Specific Aims are (1) to develop and evaluate xenon CT imaging biomarkers and compare the cross-sectional differences between BOS stages in lung transplant recipients; (2) to determine whether longitudinal changes in xenon CT imaging biomarkers are associated with longitudinal changes in pulmonary function measures in patients with early BOS; and (3) to compare lung segmental abnormalities of xenon CT imaging biomarkers with histopathological abnormalities of segmental airways in selected patients. Completion of these aims will quantify cross-sectional (Aim 1) and longitudinal (Aim 2) associations between the xenon CT imaging biomarkers and pulmonary function, providing a key first step in establishing their utility as regional imaging markers for BOS progression in transplanted lungs.
描述(由申请人提供):肺移植是晚期肺部疾病患者的重要治疗选择。事实上,大多数患者在移植后可以期待出色的功能恢复和改善的生活质量。尽管早期存活率和功能有所改善,但闭塞性毛细支气管炎(OB)是一种普遍进行性的小气道功能丧失,严重威胁着肺移植受者(LTRS)的长期前景。闭塞性细支气管炎综合征(BOS)是最常见的慢性并发症,影响大多数移植后5年存活的患者。BOS的主要临床特征是经肺功能检测(PFT)确诊的呼吸道阻塞。然而,PFT是一项全球肺功能测量,不提供有关区域性疾病参与或早期BOS的信息。为了预防或延迟BOS的发生,直接评估当地OB的区域发展将是有用的。区域OB图将使我们能够评估BOS的机制,疾病进展,并为特定肺部区域的图像引导活检或治疗提供工具,以提高早期治疗干预的效果。然而,传统的CT或MR成像是有限的,不能同时评估与BOS早期变化相关的区域通气性和形态变化。因此,我们开发了一种新的氙气CT局部通风成像技术和肺形态定量分析方法,并提出这些新工具对于研究移植肺的功能和形态变化以及参与同种异体移植肺功能障碍发生发展的潜在机制是至关重要的。主要目的是评估我们的氙气CT成像技术,以评估区域通气性和形态变化,并将这些变化与肺功能测试和BOS进展联系起来。这项研究具有创新性,因为我们开发了一种新的氙气CT肺成像技术和一种新的、有效和可靠的半自动交互分割方法。我们的中心假设是,氙气CT可以用来量化肺部局部通风和形态的变化,并将这些变化与肺功能和疾病进展联系起来。具体目的是(1)开发和评估Xe-CT成像生物标记物,比较肺移植受者BOS分期之间的横断面差异;(2)确定Xe-CT成像生物标记物的纵向变化是否与早期BOS患者肺功能指标的纵向变化相关;(3)比较部分患者的Xe-CT成像生物标记物的肺段异常与节段性呼吸道的组织病理学异常。这些目标的完成将量化氙气CT成像生物标记物与肺功能之间的横截面(目标1)和纵向(目标2)关联,为确定其作为移植肺BOS进展的区域成像标记物的实用性提供关键的第一步。

项目成果

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{{ truncateString('KYONGTAE T BAE', 18)}}的其他基金

Consortium for Radiologic Imaging Studies in Polycystic Kidney Disease (CRISP)
多囊肾放射影像研究联盟 (CRISP)
  • 批准号:
    9273112
  • 财政年份:
    2016
  • 资助金额:
    $ 19.25万
  • 项目类别:
Assessing Xenon CT Imaging Biomarkers in Lung Transplant Recipients
评估肺移植受者的氙气 CT 成像生物标志物
  • 批准号:
    8769552
  • 财政年份:
    2014
  • 资助金额:
    $ 19.25万
  • 项目类别:
Imaging Biomarkers for Parkinson's Disease using 7 Tesla MRI
使用 7 特斯拉 MRI 对帕金森病的生物标志物进行成像
  • 批准号:
    7848815
  • 财政年份:
    2009
  • 资助金额:
    $ 19.25万
  • 项目类别:
Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary Embolism
识别与肺栓塞预后相关的 CT 成像生物标志物
  • 批准号:
    8117504
  • 财政年份:
    2008
  • 资助金额:
    $ 19.25万
  • 项目类别:
Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary Embolism
识别与肺栓塞预后相关的 CT 成像生物标志物
  • 批准号:
    7904135
  • 财政年份:
    2008
  • 资助金额:
    $ 19.25万
  • 项目类别:
Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary Embolism
识别与肺栓塞预后相关的 CT 成像生物标志物
  • 批准号:
    7691282
  • 财政年份:
    2008
  • 资助金额:
    $ 19.25万
  • 项目类别:
Identifying CT Imaging Biomarkers Associated with Prognosis of Pulmonary Embolism
识别与肺栓塞预后相关的 CT 成像生物标志物
  • 批准号:
    8311726
  • 财政年份:
    2008
  • 资助金额:
    $ 19.25万
  • 项目类别:
DATA COORDINATING AND IMAGING ANALYSIS CENTER (DCIAC)
数据协调和成像分析中心 (DCIAC)
  • 批准号:
    6177799
  • 财政年份:
    1999
  • 资助金额:
    $ 19.25万
  • 项目类别:
DATA COORDINATING AND IMAGING ANALYSIS CENTER (DCIAC)
数据协调和成像分析中心 (DCIAC)
  • 批准号:
    6358219
  • 财政年份:
    1999
  • 资助金额:
    $ 19.25万
  • 项目类别:
DATA COORDINATING AND IMAGING ANALYSIS CENTER (DCIAC)
数据协调和成像分析中心 (DCIAC)
  • 批准号:
    6476242
  • 财政年份:
    1999
  • 资助金额:
    $ 19.25万
  • 项目类别:

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复合同种异体移植促进角膜移植的存活
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  • 财政年份:
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Composite Allografting for Promoting Survival of Corneal Transplants
复合同种异体移植促进角膜移植的存活
  • 批准号:
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增强同种异体移植后的抗肿瘤免疫力
  • 批准号:
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  • 财政年份:
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Augmenting Antitumor Immunity after Allografting
增强同种异体移植后的抗肿瘤免疫力
  • 批准号:
    8010394
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