Consortium for Radiologic Imaging Studies in Polycystic Kidney Disease (CRISP)

多囊肾放射影像研究联盟 (CRISP)

• 批准号: 9273112
• 负责人: KYONGTAE T BAE
• 金额: $ 8万
• 依托单位: UNIVERSITY OF PITTSBURGH AT PITTSBURGH
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2017-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9273112
• 关键词: Affect; Age; Alabama; Autosomal Dominant Polycystic Kidney; Biological; Biological Markers; Clinic; Clinical Trials; Counseling; Cyst; Cystic kidney; Diet; Disease Progression; End stage renal failure; Genotype; Goals; Growth; Hepatic Cyst; Image; Instruction; Intake; Intervention; Kansas; Kidney; Kidney Failure; Life Expectancy; Magnetic Resonance; Measurement; Methods; Modeling; Morbidity - disease rate; Participant; Patient Outcomes Assessments; Patients; Pattern; Phenotype; Polycystic Kidney Diseases; Quality of life; Renal Blood Flow; Research Personnel; Risk; Risk Factors; Sampling; Severity of illness; Sodium; Surrogate Markers; Testing; Universities; Washington; base; drug development; follow-up; improved; modifiable risk; predictive marker; rate of change; sex

Autosomal dominant polycystic kidney disease (ADPKD) is a major cause of morbidity and is the fourth leading cause of ESRD In the world, affecting more than 500,000 U.S. citizens. Researchers at the University of Alabama, Emory University, University of Kansas, Mayo Clinic and Washington University joined together in 2000 to create the Consortium for Radiologic Studies of Polycystic Kidney Disease (CRISP I) and In 2006 included the University of Pittsburgh in place of Washington University for CRISP II. The primary objectives of CRISP I and II were to: establish accurate, reliable and reproducible magnetic resonance based measurements of total kidney volume (TKV), liver cyst volume (LCV), renal blood flow (RBF), and patterns of cyst growth and expansion. Based on 7.3 years of longitudinal follow-up in 200 CRISP I/I I participants, we can now 1) establish an unequivocal relationship between TKV and qualitative (patient reported outcomes) and quantitative (renal insufficiency) end-points; as well as 2) identify potential modifiable risk factors associating with TKV and LCV to intervene upon. TKV ultimately may be used as a surrogate marker of disease progression in clinical trials. The goals of CRISP III extend the observations of CRISP l/ll. The overarching Aim for CRISP III is to develop and enhance prediction models that best predict renal insufficiency in ADPKD. Specifically, Aim 1; Extend the serial quantification of TKV and LCV to develop and test new models for predicting the risk of developing renal insufficiency. Aim 2: Determine the extent to which age and sex-adjusted measurements of RBF predict the rate of change in TKV and determine if RBF and TKV independently predict the risk of developing renal insufficiency. Aim 3: Develop methods to quantify the influence of renal cyst number, volume, and topography at baseline on the subsequent course of TKV and GFR and the risk of developing renal insufficiency. Aim 4: Expand and analyze CRISP biological samples to improve genotype/phenotype and biomarker studies. Aim 5. Determine whether intensive dietary counseling and intervention in a small group of CRISP participants is successful in modifying the relatively fixed pattern of sodium intake observed in CRISP I and reducing the rate of growth of the polycystic kidneys. RELEVANCE (See instructions): The results of these studies will impact the lives of patients with ADPKD. Developing predictive markers of disease severity early, prior to loss of renal insufficiency will result in increased efficiency of theray/drug development and result in increased life expectancy and improved quality of life in patients with ADPKD.

常染色体显性遗传性多囊肾病（ADPKD）是发病的主要原因，是第四位 ESRD的主要原因在世界上，影响超过50万美国公民。的研究人员 亚拉巴马大学、埃默里大学、堪萨斯大学、马约诊所和华盛顿大学 在2000年联合起来创建了多囊肾病放射学研究联盟（CRISP 2006年，匹兹堡大学取代华盛顿大学参加了CRISP II。的 CRISP I和II的主要目标是：建立准确、可靠和可重现的磁性 基于共振的肾脏总体积（TKV）、肝囊肿体积（LCV）、肾血流量测量 (RBF)以及包囊生长和扩张的模式。基于200年7.3年的纵向随访 CRISP I/I I参与者，我们现在可以1）建立TKV和定性之间的明确关系 （患者报告的结局）和定量（肾功能不全）终点;以及2）确定潜在的 与TKV和LCV相关的可改变的风险因素进行干预。TKV最终可能被用作 临床试验中疾病进展的替代标志物。CRISP III的目标扩展了 CRISP l/ll. CRISP III的总体目标是开发和增强预测模型， 肾功能不全的症状具体而言，目标1：扩展TKV和LCV的系列定量，以开发 并测试预测肾功能不全风险的新模型。目标2：确定 经年龄和性别调整的RBF测量值预测TKV的变化率，并确定RBF是否 和TKV独立预测发生肾功能不全的风险。目标3：制定量化方法 基线时肾囊肿数量、体积和地形对TKV后续过程的影响 GFR和肾功能不全的风险。目的4：扩展和分析CRISP生物 样本，以改善基因型/表型和生物标志物的研究。目标5。确定强化饮食是否 一小群CRISP参与者的咨询和干预成功地改变了相对 CRISP I中观察到的钠摄入固定模式，并降低了多囊肾的生长速度。 相关性（参见说明）： 这些研究的结果将影响ADPKD患者的生活。开发预测标记物 在肾功能不全消失之前，疾病严重程度越早，治疗/药物的效率越高 发展，并导致ADPKD患者的预期寿命延长和生活质量改善。