Motor Imagery: A Pilot Intervention for Improving Gait and Cognition in the Elderly

运动意象：改善老年人步态和认知的试点干预

• 批准号: 9109738
• 负责人: Helena M Blumen
• 金额: $ 13.05万
• 依托单位: ALBERT EINSTEIN COLLEGE OF MEDICINE, INC
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-15 至 2020-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9109738
• 关键词: Adherence; Adult; Age; Award; Basal Ganglia; Brain region; Clinical Research; Clinical Trials; Cognition; Cognitive; Communities; Dementia; Elderly; Foundations; Frail Elderly; Functional Magnetic Resonance Imaging; Funding; Future; Gait; Gait abnormality; Health; Home environment; Hospitalization; Imagery; Impaired cognition; Impairment; Intervention; Intervention Studies; Letters; Link; Measures; Medical; Morbidity - disease rate; Motor; Motor Cortex; Neurologic; Neuronal Plasticity; Outcome; Outcome Measure; Parkinson Disease; Participant; Patients; Pattern; Performance; Physical Exercise; Population; Prefrontal Cortex; Protocols documentation; Randomized; Randomized Clinical Trials; Randomized Controlled Trials; Recording of previous events; Rehabilitation therapy; Research; Research Personnel; Risk; Scanning; Sex Education; System; Testing; Therapeutic; Time; Training Activity; Visit; Walking; Work; active control; age related; base; career development; cognitive function; cognitive performance; design; disability; efficacy testing; executive function; exercise program; fall risk; falls; frailty; improved; knowledge base; mortality; neuroimaging; neuropsychological; post intervention; post stroke; primary outcome; programs; protocol development; public health relevance; relating to nervous system; response; tool; visual imagery; visual process; visual processing

 DESCRIPTION (provided by applicant): Over a third of community-residing elders have clinically diagnosable gait abnormalities, and gait impairment has been linked to an increased risk for morbidity, hospitalization, mortality, cognitive decline, and dementia. Convincing new studies in Parkinson's disease and post stroke suggest that motor imagery - envisioning motor actions without actual execution - is an effective rehabilitative tool, but the efficacy of motor imagery for improving gait in relatively healthy elderly is currently unknown. The proposed research aims to establish the efficacy of an imagined gait protocol for improving both gait in healthy elderly. This imagined gait protocol involves imagined gait in single (imagined walking; iW) and dual-task (imagined walking while talking; iWWT) situations, demands executive functions (EF), and has been validated against an actual gait protocol that involves an ecologically- valid dual-task situation (walking while talking; WWT) that predicts falls, frailty, disability and mortality in the elderly. A pilot Randomized Clinical Trial of 48 cognitively-health elderly with pre-post measures of gait, EF, and fMRI during imagined gait is proposed. The overall working hypothesis is that imagined gait can be used as a rehabilitative tool for improving gait in the elderly because it engages and strengthens similar neural systems as actual gait. The first aim of this pilot is to establish the efficacy of our imagined gait protocolto improve gait and EF in the elderly. We predict that our imagined gait intervention will improve: 1) gait velocity during actual W and WWT conditions to a greater extent than the Active Control (AC; Visual imagery), and 2) improve cognitive performance during actual T and WWT conditions to a greater extent than the AC condition. The second aim of this pilot is to determine neuroplasticity changes in response to our imagined gait intervention. We predict that: 1) our imagined gait protocol engages neural systems linked to actual gait and EF, while the AC condition engages neural systems linked to visual processing and imagery in general, and 2) the neural systems engaged during our imagined gait protocol are strengthened following our imagined gait intervention. This pilot RCT has the potential to build the foundation for a future full-scale RCT to test the therapeutic potential of imagined gait in the elderly.

 描述（由申请人提供）：超过三分之一的社区老年人有临床诊断的步态异常，步态障碍与发病率、住院率、死亡率、认知能力下降和痴呆症的风险增加有关。令人信服的帕金森氏病和中风后的新研究表明，运动想象-想象没有实际执行的运动动作-是一种有效的康复工具，但运动想象改善相对健康的老年人步态的功效目前尚不清楚。拟议的研究旨在建立一个想象的步态协议，以改善健康老年人的步态的有效性。该想象步态协议涉及在单任务（想象行走; iW）和双任务（想象边行走边说话; iWWT）情况下的想象步态，要求执行功能（EF），并且已经针对实际步态协议进行了验证，该实际步态协议涉及预测老年人中的福尔斯、虚弱、残疾和死亡率的生态有效的双任务情况（边行走边说话; WWT）。一个试点随机临床试验的48个认知健康的老年人的步态，EF，和功能磁共振成像在想象的步态前后措施。总体工作假设是，想象步态可以用作改善老年人步态的康复工具，因为它参与并加强了与实际步态相似的神经系统。本试验的第一个目的是确定我们想象的步态方案对改善老年人步态和EF的有效性。我们预测，我们想象的步态干预将得到改善：1） 在实际W和WWT条件下的步态速度比主动控制（AC;视觉图像）更大程度，以及2）在实际T和WWT条件下的认知表现比AC条件更大程度的改善。这个试验的第二个目的是确定神经可塑性的变化，以响应我们想象的步态干预。我们预测：1）我们想象的步态协议涉及与实际步态和EF相关的神经系统，而AC条件涉及与视觉处理和一般图像相关的神经系统，以及2）在我们想象的步态协议期间参与的神经系统在我们想象的步态干预后得到加强。这项试点随机对照试验有可能为未来的全面随机对照试验奠定基础，以测试老年人想象步态的治疗潜力。