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Circadian Rhythm in GI Health and Disease

胃肠道健康和疾病中的昼夜节律

基本信息

批准号：
9040506
负责人：
Faraz Bishehsari
金额：
$ 2万
依托单位：
RUSH UNIVERSITY MEDICAL CENTER
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-05-05 至 2017-05-04
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9040506
关键词：
Address Affect Alcohols Biological Rhythm Brain Cell Proliferation Cell physiology Chronic Disease Chronotherapy Circadian Rhythms Clinical Collaborations Colon Carcinoma Communication Country Diet Digestive System Disorders Disease Doctor of Philosophy Eating Environment Europe Feeding Patterns Food Food Processing Future Gastrointestinal Diseases Gastrointestinal tract structure Goals Health Hepatic Homeostasis Hypothalamic structure Immune Incidence Inflammatory Bowel Diseases Inflammatory disease of the intestine International Intestines Jet Lag Syndrome Lead Learning Life Style Light Link Liver Liver diseases Malignant Neoplasms Malignant neoplasm of gastrointestinal tract Medical Research Metabolic Metabolic Diseases Metabolic syndrome Metabolism Motor Neurologic Obesity Pathology Pathway interactions Periodicity Peripheral Permeability Physiological Processes Postdoctoral Fellow Predisposition Prevention Process Regulation Research Personnel Role Science Scientist Sleep Social Workers Societies System Therapeutic Time Tissues Training Translating carcinogenesis circadian pacemaker collaborative environment gastrointestinal gastrointestinal system human data human disease microbial microbiota non-alcoholic novel nutrition problem drinker public health relevance suprachiasmatic nucleus symposium

项目摘要

DESCRIPTION (provided by applicant): Circadian clocks are involved in almost all physiologic processes. Similarly, circadian rhythms is shown to be important in regulating variety of processes in our digestive system, including cell proliferation, immune homeostasis, gut permeability and microbial imbalance. Therefore it is not surprising that disruption of circadian rhythm, a factor associated with modern life style, has been implicated in a variety of GI related pathologies that are on the rise in Western countries. These conditions include but are not limited to functional GI diseases, inflammatory bowel disease, alcoholic and non-alcoholic liver disease, metabolic disorders, obesity and gastrointestinal (GI) cancers (e.g., colon cancer. Despite the growing recognition of circadian regulation in GI health and disease, many investigators including basic scientists and clinical researchers, as well as practicing clinicians, are unaware of the importance of this topic for both prevention and treatment of variety of gastrointestinal, hepatic, metabolic and neurologic pathologies. Here we propose a symposium on "circadian rhythm in GI health and disease" which will, for the first time, cover the impact of circadian dysrhythmia on variety of digestive ad alcohol related pathologies such as gut inflammation, liver diseases, metabolic syndromes, GI cancers as well as brain-gut pathways. Also this symposium will provide scientists, post-doctoral fellows, fellows-in-training, clinicians, and clinician-scientists with a highly dynamic and interactive environment to discuss and learn about the role of circadian rhythms in GI/liver and metabolic/nutrition diseases. Young researchers will be encouraged to enter the field, and multi-central collaborations will form to, eventually, advance our understanding of circadian clock in our digestive system.