Circadian Rhythm in GI Health and Disease

 描述(由申请人提供)： 生物钟几乎参与了所有的生理过程。同样，昼夜节律在调节消化系统的各种过程中也很重要，包括细胞增殖、免疫动态平衡、肠道通透性和微生物失衡。因此，与现代生活方式相关的昼夜节律紊乱与各种与胃肠道疾病相关的疾病有关也就不足为奇了，这些疾病在西方国家正在上升。这些疾病包括但不限于功能性胃肠道疾病、炎症性肠病、酒精性和非酒精性肝病、代谢紊乱、肥胖和胃肠道癌症(例如结肠癌)。尽管人们越来越多地认识到昼夜节律在胃肠道健康和疾病中的作用，但许多研究人员，包括基础科学家和临床研究人员，以及执业临床医生，都没有意识到这一主题对两者的重要性 预防和治疗各种胃肠道、肝脏、代谢和神经疾病。在这里，我们提议召开一场名为“胃肠道健康和疾病中的昼夜节律”的研讨会，该研讨会将首次涵盖昼夜节律紊乱对各种与消化和酒精相关的病理的影响，如肠道炎症、肝脏疾病、代谢综合征、胃肠道癌症以及脑-肠道通路。此外，本次研讨会还将为科学家、博士后研究员、受训研究员、临床医生和临床医生科学家提供一个高度动态和互动的环境，以讨论和了解昼夜节律在胃肠道/肝脏和代谢/营养疾病中的作用。年轻的研究人员将被鼓励进入该领域，最终将形成多中心合作，以促进我们对消化系统生物钟的理解。

 DESCRIPTION (provided by applicant): Circadian clocks are involved in almost all physiologic processes. Similarly, circadian rhythms is shown to be important in regulating variety of processes in our digestive system, including cell proliferation, immune homeostasis, gut permeability and microbial imbalance. Therefore it is not surprising that disruption of circadian rhythm, a factor associated with modern life style, has been implicated in a variety of GI related pathologies that are on the rise in Western countries. These conditions include but are not limited to functional GI diseases, inflammatory bowel disease, alcoholic and non-alcoholic liver disease, metabolic disorders, obesity and gastrointestinal (GI) cancers (e.g., colon cancer. Despite the growing recognition of circadian regulation in GI health and disease, many investigators including basic scientists and clinical researchers, as well as practicing clinicians, are unaware of the importance of this topic for both prevention and treatment of variety of gastrointestinal, hepatic, metabolic and neurologic pathologies. Here we propose a symposium on "circadian rhythm in GI health and disease" which will, for the first time, cover the impact of circadian dysrhythmia on variety of digestive ad alcohol related pathologies such as gut inflammation, liver diseases, metabolic syndromes, GI cancers as well as brain-gut pathways. Also this symposium will provide scientists, post-doctoral fellows, fellows-in-training, clinicians, and clinician-scientists with a highly dynamic and interactive environment to discuss and learn about the role of circadian rhythms in GI/liver and metabolic/nutrition diseases. Young researchers will be encouraged to enter the field, and multi-central collaborations will form to, eventually, advance our understanding of circadian clock in our digestive system.