Optimizing HIV care for patients with substance use disorders using predictive analytics in a mobile health application

在移动健康应用程序中使用预测分析优化对药物滥用患者的艾滋病毒护理

• 批准号: 9180574
• 负责人: Ryan Patrick Westergaard
• 金额: $ 229.5万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-06-01 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9180574
• 关键词: Address; Alcohol or Other Drugs use; Alcohols; Anti-Retroviral Agents; Caring; Cellular Phone; Clinical; Clinical Trials; Communities; Competence; Data; Data Reporting; Disease; Drug usage; Effectiveness; Effectiveness of Interventions; Event; Genetic Crossing Over; Goals; HIV; HIV Seropositivity; HIV risk; Health; Health system; Intervention; Lead; Life; Logistic Regressions; Modeling; Moods; Opioid; Participant; Patient Care; Patients; Phase; Population; Predictive Analytics; Provider; Recording of previous events; Risk; Running; Social support; Staging; Substance Use Disorder; Testing; Time; Translating; Treatment Failure; Viral; Viral Load result; addiction; antiretroviral therapy; base; coping; design; evidence base; experience; health application; high risk; improved; innovation; intrinsic motivation; mHealth; negative mood; predictive modeling; prevent; public health relevance; reduced substance use; relapse risk; scale up; social; transmission process

PROJECT SUMMARY It is now well-accepted that lowering community viral load through scale-up of antiretroviral therapy (ART) can reduce HIV transmission among people who use drugs. However, achieving durable viral suppression among patients with substance use disorders is a major challenge for clinical providers and health systems. Patients with substance use disorders are continuously at risk for relapse and other disruptive life events. This can lead to frequent lapses in antiretroviral treatment and subsequent viral rebound, which increases the risk of health problems related to HIV and the risk of transmitting HIV to others. This project addresses the problem of lapses in antiretroviral treatment by testing the effectiveness of an innovative mobile health (mHealth) system designed to support people living with HIV and substance use disorders who are receiving HIV care. The mHealth intervention, called A-CHESS, is an evidence-based smartphone application previously shown to reduce substance use and improve retention in addiction treatment by improving social connectedness, intrinsic motivation and coping competence. In this 2-stage, crossover clinical trial, we will provide smartphones running the A-CHESS application to 150 HIV-positive patients who have a past-year history of alcohol, opioid, or stimulant use disorder. In the first phase, participants will use the A-CHESS application to report data in real time describing their drug use, mood, social support, and other factors during a 6-month ecologic momentary assessment (EMA) study. These data will be used to develop and validate a predictive model of treatment non-adherence in this population. After 6 months, all patients will cross over to the second study phase, during which the full, multi-component, tailored mHealth intervention will be delivered using the A-CHESS platform. Simultaneously, data captured by A-CHESS describing participants' risk of treatment lapse will be communicated to patient's providers and clinical support staff, allowing timely and focused support interventions. The effectiveness of the intervention for improving the rate of viral suppression will be assessed using a mixed effects logistic regression model. This project has the potential for high impact because it identifies the critical time-varying determinants of lapses in HIV care for substance using patients, and translates these diverse inputs into actionable, patient-specific alerts to clinical providers.

项目总结