Effects of Apparent Body Size on Motor Function

表观身体尺寸对运动功能的影响

• 批准号: 9031829
• 负责人: H BRANCH COSLETT
• 金额: $ 20万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-03-15 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9031829
• 关键词: Address; Anatomy; Anterior; Appearance; Body Size; Brain; Clinical; Data; Fingers; Hand; Hand Strength; Health; Image; Individuation; Intervention; Investigation; Judgment; Lesion; Measures; Mediating; Motor; Motor Cortex; Motor Evoked Potentials; Muscle; Pain; Pain intensity; Perception; Performance; Physiologic pulse; Process; Rehabilitation therapy; Sensory; Site; Tactile; Therapeutic Intervention; Time; Transcranial magnetic stimulation; Visual; Work; chronic stroke; follow-up; grasp; hemiparesis; improved; lens; motor function improvement; neuromechanism; novel; predicting response; research study

 DESCRIPTION (provided by applicant): Changing the apparent size of the body using magnifying lenses has been demonstrated to influence perceptual judgments about the body as well as judgments of pain intensity. In preliminary data from normal and brain lesion subjects we have demonstrated for the first time that altering the apparent size of the body influences motor processing as well. More specifically, magnifying the image of the hand improved both finger tapping and grip strength. The major objective of the proposed study is to systematically explore the effects of magnification on finger tapping rate, grip strength, reach-to-grasp and finger individuation tasks in subjects with brain lesions. A secondary objective is to identify the mechanisms underlying this effect; to that end, three experiments involving Transcranial Magnetic Stimulation will be performed in normal subjects. The proposed investigations have clear and substantial clinical implications. The demonstration that a simple, inexpensive and safe intervention enhances motor function would provide a novel and potentially efficacious therapeutic intervention that may serve to augment current rehabilitation practices. The proposed investigations are also of theoretical significance. Magnification effects on motor processing are a manifestation of the general phenomenon of cross-modal integration/modulation that is crucial for all sensory-motor processing. Our work will provide important information regarding the neural mechanisms underlying this basic and ubiquitous phenomenon.

 描述(由申请人提供)：使用放大镜改变身体的外观尺寸已被证明影响对身体的感知判断以及对疼痛强度的判断。在来自正常和脑损伤受试者的初步数据中，我们第一次证明了改变身体的外观大小也会影响运动处理。更具体地说，放大手的图像可以改善手指敲击和握力。这项研究的主要目的是系统地探讨放大倍数对脑损伤受试者手指敲击率、握力、触手能力和手指个性化任务的影响。第二个目标是确定这种效应背后的机制；为此，将在正常受试者身上进行三项涉及经颅磁刺激的实验。拟议的调查具有明确和实质性的临床意义。证明一种简单、廉价和安全的干预措施可以增强运动功能，这将提供一种新的、潜在有效的治疗干预措施，可能有助于加强目前的康复实践。所提出的研究也具有理论意义。对运动加工的放大效应是对所有感觉-运动加工至关重要的跨模式整合/调制这一普遍现象的表现。我们的工作将提供关于这种基本而普遍存在的现象背后的神经机制的重要信息。