IGF::OT::IGF BLDG. 469- 2ND FLOOR REFURBISHMENT & INFRASTRUCTURE

IGF::OT::IGF 大厦。

• 批准号: 9369499
• 负责人: HEIDI CHERRY
• 金额: $ 525.54万
• 依托单位: LEIDOS BIOMEDICAL RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-12 至 2018-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9369499
• 关键词: Animals; Biological Assay; Breeding; Chemicals; Discipline; Dissection; Effectiveness; Environment; Equipment; Evaluation; Floor; Genes; Genetically Engineered Mouse; Genotype; Glass; Health; Housing; Image; Image Analysis; Immunohistochemistry; Laboratories; Laboratory Animals; Lasers; Location; Mission; Molecular; Monitor; Mus; Pathology; Process; Protocols documentation; Research; Research Activity; Research Design; Research Infrastructure; Research Personnel; Research Support; Robot; Rodent; Safety; Sampling; Services; Slide; Special Equipment; Staining method; Stains; Sterility; System; Tissue Microarray; Training; Update; Vent; animal facility; base; design; exhaust; histotechnology; instrumentation; interest; laboratory equipment; medical specialties; meetings; molecular diagnostics; programs; wasting

The Building 469, second floor refurbishment is planned to consolidate and provide appropriate laboratory space for the Pathology and Histotechnology Laboratory, the Animal Molecular Diagnostic Laboratory and the High-Throughput Mouse Genotyping Laboratory which provide scientific support services for the animal-based research activities of NCI investigators. Specifically, the Pathology and Histotechnology Laboratory assists in animal study design and provides imaging and image analysis, laser capture micro-dissection, immunohistochemistry, tissue microarray and pathology evaluation. The Animal Molecular Diagnostic Laboratory is responsible for the health monitoring of all rodents at the NCI-operated animal facilities in Frederick and Bethesda and focusses on the use of molecular assays such as PCR. The High-Throughput Mouse Genotyping Laboratory providing genotyping services to investigators breeding genetically engineered mice to identify mice baring particular genes of interest, which are then used in experimental protocols and focusses on the use of automated assays so that high numbers of animals can be genotyped quickly. The co-location of these laboratories will allow these groups to share equipment/instrumentation and to cross-train and share staff across the different disciplines to enhance efficiencies and effectiveness.

469号楼二楼的翻新计划是为了巩固病理学和组织技术实验室、动物分子诊断实验室和高通量小鼠基因分型实验室，并为这些实验室提供适当的实验室空间，这些实验室为NCI研究人员的动物研究活动提供科学支持服务。 具体而言，病理学和组织技术实验室协助动物研究设计，并提供成像和图像分析，激光捕获显微解剖，免疫组织化学，组织微阵列和病理学评估。 动物分子诊断实验室负责在弗雷德里克和贝塞斯达的国家癌症研究所经营的动物设施的所有啮齿动物的健康监测，并专注于使用分子检测，如PCR。 高通量小鼠基因分型实验室为研究人员提供基因分型服务，培育基因工程小鼠，以识别携带特定感兴趣基因的小鼠，然后将其用于实验方案，并专注于使用自动化检测，以便快速对大量动物进行基因分型。 这些实验室合用同一地点将使这些团体能够共用设备/仪器，并交叉培训和共用不同学科的工作人员，以提高效率和效力。