Investigation into protein quality control pathways in Dictyostelium discoideum

项目总结/摘要 蛋白质病是一类至少71种疾病，其特征在于蛋白质聚集体的积累。 蛋白质聚集体是由蛋白质稳态的失衡引起的，导致蛋白质聚集体的积累。 错误折叠的蛋白质生物医学研究中的一个主要问题是：细胞如何识别和处理 错误折叠的蛋白质我们偶然发现，模式生物盘基网柄藻（Dictyosteelium discoideum） 表达具有长的多聚谷氨酰胺束的蛋白质，所述长的多聚谷氨酰胺束引起一类蛋白质病。我们最近 表明网骨藻具有抵抗聚谷氨酰胺膨胀聚集的非凡能力 在其他模式生物中聚集的蛋白质。在这里，我们建议调查的机制， Dictyosteoprotein抵抗多聚谷氨酰胺聚集并探索Dictyosteoprotein蛋白的新方面 质量控制网。

Project Summary/Abstract Proteopathies are a class of at least 71 diseases characterized by the accumulation of protein aggregates. Protein aggregates are caused by an imbalance in protein homeostasis resulting in the accumulation of misfolded proteins. One major question in biomedical research is: How do cells recognize and deal with misfolded proteins? Serendipitously, we found that the model organism Dictyostelium discoideum normally expresses proteins with long polyglutamine tracts that cause one class of proteopathy. We have recently shown that Dictyostelium have an extraordinary ability to resist aggregation of a polyglutamine expanded protein know to aggregate in other model organisms. Here we propose to investigate mechanisms utilized by Dictyostelium to resist polyglutamine aggregation and explore novel aspects of the Dictyostelium protein quality control network.