维生素 D 在慢性肾脏病中的以患者为导向的研究-猫眼课题宝

维生素 D 在慢性肾脏病中的以患者为导向的研究

批准号：

9026599

负责人：

RAVI THADHANI

金额：

$10.92万

依托单位：

MASSACHUSETTS GENERAL HOSPITAL

依托单位国家：

美国

项目类别：

财政年份：

2012

资助国家：

美国

项目状态：

已结题

起止时间：

2012-04-15 至 2017-03-31

来源：

https://reporter.nih.gov/project-details/9026599

关键词：

Address Back Benefits and Risks Biological Biological Markers Biology Blood specimen Bone Diseases Canada Cardiac Cardiac Myocytes Cardiovascular Diseases Cause of Death Chronic Chronic Kidney Failure Clinical Research Data Set Diabetes Mellitus Dialysis patients Dialysis procedure Disease Disease Progression Dose Educational process of instructing End stage renal failure Ergocalciferols Escherichia coli Funding Funding Agency Gene Expression Generations Goals Grant Health Heart Hypertrophy Hemodialysis Hormones Hospitalization Hypercalcemia Immune response Individual Industry Infection Inflammation Mediators Inflammatory Institutes Intervention Kidney Failure Laboratories Lead Left Ventricular Hypertrophy Left Ventricular Mass Link Measures Mediating Mentors Mentorship Metabolism Mid-Career Clinical Scientist Award (K24)Molecular Profiling Morbidity - disease rate National Institute of Diabetes and Digestive and Kidney Diseases Nephrology New England Nutritional Patients Placebos Plasma Population Population Characteristics Public Health Qualifying Regimen Research Research Personnel Risk Factors Safety Scientist Single Nucleotide Polymorphism Slice Staging Students Supplementation Testing Time Toxic effect Training United States National Institutes of Health Vitamin D Vitamin D Analog Vitamin D Deficiency Vitamin D supplementation Vitamin D3 Receptor Vitamins base capsule cardiovascular disorder risk cardiovascular infection cardiovascular visualization career cathelicidin clinically relevant cohort coronary artery calcification cytokine fibroblast growth factor 23 follow-up improved indexing inorganic phosphate macrophage mortality paricalcitol patient oriented patient oriented research personalized diagnostics programs prospective randomized trial response skills translational study treatment duration treatment response

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DESCRIPTION (provided by applicant): Vitamin D deficiency is highly prevalent in patients with advanced chronic kidney disease (CKD). Cardiovascular disease (CVD) and infection are the top causes of morbidity and mortality in CKD and end- stage renal disease (ESRD). Evidence generated by the candidate's (Ravi Thadhani, MD, MPH) laboratory has linked CVD progression and altered immune response to inadequate vitamin D levels in CKD/ESRD. Under Dr. Thadhani's direction, a comprehensive patient-oriented research program seeks to investigate the relationship between vitamin D biology and supplementation strategies in terms of mechanistic and clinically relevant endpoints. This application describes three unique aims in three studies (each backed by separate funding sources) that will be pursued by the candidate and his trainees: (1) in DIVINE - an NIH sponsored trial of nutritional vitamin D - his team will determine whether nutritional vitamin D deficiency in ESRD patients leads to altered macrophage function and ex-vivo response to infection; (2) in PRIMO - an industry sponsored trial of active vitamin D and left ventricular hypertrophy [LVH], diastolic function, and cardiac hospitalization in patients with stage 3/4 CKD - his team will determine if baseline levels of 25-hydroxy vitamin D (25D) and fibroblast growth factor-23 (FGF-23) are linked to progression or lack of regression of LVH; and (3) in LUCID - a prospective cohort of incident ESRD subjects supported by the Canadian Institutes of Health - his team will examine whether active vitamin D leads to excess coronary artery calcification. By supporting the candidate's request for this K24 award, important patient-oriented questions will be addressed. Moreover, Dr. Thadhani, with an exemplary record of mentorship, teaching and research, will be afforded the necessary protected time to mentor individuals who comprise a new generation of clinical research fellows and students in Nephrology.

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