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Support of the Emory National Primate Research Center

埃默里国家灵长类动物研究中心的支持

基本信息

批准号：
10844283
负责人：
RAVI THADHANI
金额：
$ 16.99万
依托单位：
EMORY UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-08-01 至 2026-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10844283
关键词：
AIDS prevention Address Affinity Anatomy Antibodies Antibody Response Antigens B-Lymphocytes Binding Biopsy Bone Marrow CD4 Positive T Lymphocytes CD8-Positive T-Lymphocytes Cells Clinical Trials Conduct Clinical Trials Epidemic Follow-Up Studies Goals Grant HIV HIV vaccine HIV-1 HIV/AIDS Human Immune response Immunization Immunohistochemistry Infection prevention Inflammatory Intramuscular Knock-in Mouse Length Macaca mulatta Measures Messenger RNA Modified Vaccinia Virus Ankara Mucous Membrane Mutate Mutation Outcome Positioning Attribute Prevention Primates Production Proteins RNA vaccination Research Route SIV Sampling Scientist Structure of germinal center of lymph node T cell response T-Lymphocyte United States National Institutes of Health Vaccination Vaccines Viral Visualization coronavirus disease design experimental study gp160 immunogenicity improved mouse model neutralizing antibody nonhuman primate novel vaccines response subcutaneous tissue resident memory T cell vaccination strategy vaccine delivery vaccine development vaccine formulation vaccine strategy

项目摘要

Abstract The overall goal of this supplement is to develop vaccine strategies that induce strong neutralizing antibody response against HIV using mRNA and modified vaccinia Ankara (MVA) vaccine delivery platforms. To address the specific goals of the supplement, we will utilize samples obtained from studies conducted in the Emory Center for HIV/AIDS Vaccine and Cure Research consortium at the Emory National Primate Research Center. We propose to use the BG505 MD39 SOSIP mRNA as our vaccine strategy to elicit bnAbs. We hypothesize that BG505 MD39 mRNA delivered intramuscularly as either full length gp160 or truncated gp140 will induce HIV specific neutralizing antibodies with broad neutralization activity in rhesus macaques. Additionally, we would like to explore the effect of heterologous SIV Gag/Pol mRNA prime and MVA boost on the CD8 T cell response and evaluate how the route of immunization alters the ability of CD8 T cells to be boosted by MVA. We propose two specific aims. In Aim 1, we will compare the immunogenicity of MD39 gp160 and gp140 mRNA IM immunization. In Aim 2, we will characterize the immune response induced through heterologous mRNA prime and MVA boost and determine if the route of immunization effects the CD8 T cell response elicited by MVA. By completion of these aims we hope to develop improved vaccination strategy against HIV that can generate both neutralizing antibodies and T cells.

摘要

项目成果

期刊论文数量（760）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Progress in developing transgenic monkey model for Huntington's disease.

DOI：
10.1007/s00702-017-1803-y
发表时间：
2018-03
期刊：
Journal of neural transmission (Vienna, Austria : 1996)
影响因子：
0
作者：
Snyder BR;Chan AWS
通讯作者：
Chan AWS

Raised without a father: monoparental care effects over development, sexual behavior, sexual reward, and pair bonding in prairie voles.

没有父亲抚养长大：单亲照料对草原田鼠的发育、性行为、性奖励和配对关系的影响。

DOI：
10.1016/j.bbr.2021.113264
发表时间：
2021-06-25
期刊：
Behavioural brain research
影响因子：
2.7
作者：
Valera-Marín G;Young LJ;Camacho F;Paredes RG;Rodríguez VM;Díaz NF;Portillo W
通讯作者：
Portillo W

p38MAPK guards the integrity of endosomal compartments through regulating necrotic death.

p38mapk通过调节坏死死亡来保护内体室的完整性。

DOI：
10.1038/s41598-022-20786-4
发表时间：
2022-09-29
期刊：
SCIENTIFIC REPORTS
影响因子：
4.6
作者：
Yao, Jia;Atasheva, Svetlana;Toy, Randall;Blanchard, Emmeline L.;Santangelo, Philip J.;Roy, Krishnendu;Mocarski, Edward S.;Shayakhmetov, Dmitry M.
通讯作者：
Shayakhmetov, Dmitry M.

Oxytocin increases eye-gaze towards novel social and non-social stimuli.

催产素增加了人们对新型社会和非社会刺激的目光。