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Cerebral Protein Synthesis as a Measure of Degenerative Changes in a Transgenic Rat Model of Alzheimer's Disease

Cerebral Protein Synthesis as a Measure of Degenerative Changes in a Transgenic Rat Model of Alzheimer's Disease
脑蛋白合成作为阿尔茨海默病转基因大鼠模型退行性变化的测量
批准号：
9357315
负责人：
CAROLYN B. SMITH
金额：
$20.33万
依托单位：
NATIONAL INSTITUTE OF MENTAL HEALTH
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/9357315
关键词：
Age-MonthsAlzheimer&aposs DiseaseAlzheimer&aposs disease modelAnimalsApoptoticAppearanceBehaviorBiological MarkersCerebral cortexCerebrumDeteriorationDiseaseDisease ProgressionEarly Onset Familial Alzheimer&aposs DiseaseFoodFundingGenesGliosisHippocampus (Brain)Human Amyloid Precursor ProteinImpaired cognitionLearningMeasuresMemoryMethodsModelingPerformancePositron-Emission TomographyProcessProtein BiosynthesisRattusSleepSmell PerceptionStagingTauopathiesTestingTimeTransgenic ModelTransgenic OrganismsTreatment Efficacyabeta depositionage relatedbehavior testcerebral amyloidosiscerebral atrophycohorthuman diseasehuman subjectmutantneuron lossnovelopen field behaviorpotential biomarkerpresenilin-1research study

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相关文献

中文摘要
翻译
在2016年资助期间，我们进行了研究，以测量rCPS与放射自显影L-1-C-14亮氨酸方法在6个月，14个月和18个月大的WT和TgF 344-AD队列。 在这些动物中，我们还测量了活动的开放领域的行为，记忆的T-迷宫，嗅觉的方式掩埋的食物任务，和睡眠行为。在另一组纵向研究的动物中，我们用L-1-C-11亮氨酸PET方法测量rCPS。 我们已经完成了行为测试，我们正在分析rCPS实验的结果。
英文摘要
During the 2016 funding period, we carried out studies to measure rCPS with the autoradiographic L-1-C-14leucine method in cohorts of WT and TgF344-AD at six, 14, and 18 months of age. In these animals we also measured activity by means of open field behavior, memory by means of the T-maze, olfaction by means of the buried food task, and sleep behavior. In a separate cohort of animals studied longitudinally we measured rCPS with the L-1-C-11leucine PET method. We have completed the behavioral testing and we are in the process of analyzing the results of the rCPS experiments.
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STUDIES ON PROTEIN SYNTHESIS AND AMINO ACID COMPARTMENTATION
DEVELOPMENT, INVOLUTION AND PLASTICITY IN THE CENTRAL NERVOUS SYSTEM
Mathematical and Statistical Analysis Techniques for in Vivo Imaging Studies
Cerebral Protein Synthesis During Sleep and Memory Consolidation