Physical Activity, Energy Balance, and Cancer

体力活动、能量平衡和癌症

• 批准号: 9339174
• 负责人: Demetrius Albanes
• 金额: $ 39.16万
• 依托单位: DIVISION OF CANCER EPIDEMIOLOGY AND GENETICS
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9339174
• 关键词: Binding Proteins; Biological Markers; Body Weight decreased; Cancer and Nutrition; Colorectal Cancer; Energy Intake; Estrogens; Etiology; Goals; Growth; Incidence; Inflammatory; Insulin-Like Growth Factor Binding Protein 3; Insulin-Like Growth Factor I; Interleukin-6; Malignant Neoplasms; Malignant neoplasm of pancreas; Obesity; Output; Phenotype; Physical activity; SHBG gene; TNF gene; Testosterone; Weight Gain; cancer prevention; cancer risk; cytokine; energy balance; improved; malignant breast neoplasm; metabolomics; multidisciplinary; novel; sedentary lifestyle; steroid hormone

The goals will be achieved by a) evaluating obesity, energy balance, and physcial activity in relation to cancer incidence and survival; b) Improving assessment of energy intake, output, and body phenotype; c) Evaluating biomarkers to determine mechanisms including inflammatory cytokines (CRP, IL-6, TNF-alpha), growth factors and their major binding proteins (IGF-1 and IGFBP-3), steroid hormones (testosterone, estrogen, SHBG) in relation to cancer and intermediate outs comes such as weight loss and weight gain d) evaluate novel such as metabolomics in assessing obesity, energy balance, and physical activity and body phenotype and in relation to cancer risk. Although this project is for all cancer, its particular cancer includes breast, colorectal, and pancreatic cancer.

这些目标将通过a)评估肥胖、能量平衡和身体活动与癌症发病率和生存率的关系来实现；b)改进能量摄入、输出和身体表型的评估；c)评估生物标志物，以确定机制，包括炎症细胞因子（CRP, IL-6, tnf - α），生长因子及其主要结合蛋白（IGF-1和IGFBP-3），类固醇激素（睾酮，雌激素，SHBG）与癌症和中间产物（如体重减轻和体重增加）有关d)评估新的代谢组学，以评估肥胖，能量平衡，身体活动和身体表型以及与癌症风险的关系。虽然这个项目适用于所有癌症，但它的特定癌症包括乳腺癌、结肠直肠癌和胰腺癌。