Wadsworth Center's Children's Health Exposure Assessment Resource (WC-CHEAR)

沃兹沃斯中心的儿童健康暴露评估资源 (WC-CHEAR)

• 批准号: 9061067
• 负责人: Kenneth M. Aldous
• 金额: $ 112.63万
• 依托单位: WADSWORTH CENTER
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-09-30 至 2019-09-04
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9061067
• 关键词: Affect; Androgens; Aromatic Polycyclic Hydrocarbons; Biochemistry; Bioinformatics; Biological; Biological Monitoring; Biomedical Research; Blood; Cerebrospinal Fluid; Chemicals; Child; Child Support; Child health care; Cholesterol; Clinical; Clinical Chemistry; Collection; Communities; Complement; Complex; Coupled; Data Analyses; Development; Electrolytes; Endocrine Disruptors; Ensure; Environment; Environmental Exposure; Environmental Health; Environmental Pollution; Estradiol; Estrogens; Exposure to; Flame Retardants; Folic Acid; Funding; Goals; Hair; Heavy Metals; Homocysteine; Homocystine; Hormones; Human; Human Resources; Insecticides; Insulin; International; Laboratories; Laboratory Research; Leadership; Mass Spectrum Analysis; Measurement; Measures; Medicine; Methods; Molecular; Nail plate; National Institute of Environmental Health Sciences; New York; Organic Chemicals; Organophosphates; Pattern; Pesticides; Pharmacology; Placenta; Plasma; Poison; Polychlorinated Biphenyls; Population; Proteins; Protocols documentation; Provider; Public Health; Research; Research Institute; Research Personnel; Resources; Role; Saliva; Sampling; Serum; Services; Spottings; Sweat; Sweating; Techniques; Testing; Testosterone; Thyroid Gland; Tooth structure; Trace Elements; Triglycerides; Umbilical Cord Blood; United States National Institutes of Health; Universities; Urine; Vitamin B 12; Vitamin D; Vitamins; Whole Blood; base; clinical toxicology; environmental stressor; experience; interest; international center; laboratory facility; medical schools; novel; novel strategies; organic contaminant; phthalates; programs; protein metabolite; public health relevance; pyrethroid; research facility; research study; response; sample collection; scientific organization; toxic metal

 DESCRIPTION (provided by applicant): The overall objective of the Wadsworth Center's Children's Health Exposure Analysis Resource (WC-CHEAR) is to establish a world-class laboratory facility that will serve the needs of NIH-funded investigators conducting research studies into the effects of environmental contaminants on children's health. The WC-CHEAR will bring together the tremendous resources, capabilities and expertise of the NY State Department of Health's public health laboratory and biomedical research facilities in Albany, NY with those of the NYU School of Medicine, Department of Biochemistry and Molecular Pharmacology. Together, this partnership between Wadsworth and NYU will provide researchers with access to state-of-the-art, specialized analytical facilities to support children's environmental health studies. The Wadsworth Center's is fully accredited under CLIA-88, and can support multiple NIH-funded studies, where children's urine and/or serum will be analyzed for organic chemical contaminants including, but not limited to, polychlorinated biphenyls, polycyclic aromatic hydrocarbons, fluorinated compounds, brominated flame retardants, organophosphate insecticides, phenolic endocrine disrupting chemicals, and phthalates using techniques based on mass spectrometry. The laboratories are also able to analyze children's biospecimens for exposure to toxic heavy metals including, but not limited to, Pb, Cd, Hg, and As using the most sensitive methods available based on inorganic mass spectrometry. The laboratories are also able to analyze children's blood, serum/plasma, and urine for endogenous compounds including hormones, vitamins, protein markers, electrolytes and metabolite panels (including but not limited to estrogens, androgens, testosterone, thyroid panels, triglycerides, cholesterol, vitamin D and B12, folate, homocysteine and insulin) that may be affected by environmental exposures. Wadsworth provides extensive capabilities for analyzing non-traditional matrices such as placenta, cord blood, baby teeth, dried blood spots, hair, nails, and saliva for organic and inorganic contaminants to support novel approaches to measure children's exposure to toxic chemicals in their environment. Capability and expertise for investigating untargeted compounds will be shared between Wadsworth and NYU, where their extensive capabilities complement each other. The WC-CHEAR will benefit from the Wadsworth Center's international reputation and leadership in the field of clinical laboratory medicine, and as an organizer of proficiency testing (PT) programs in environmental laboratory medicine, clinical chemistry and toxicology. The experience and capability that Wadsworth brings in this regard will provide the NIEHS Children's Health Environmental Analytical Resource (CHEAR) network with a PT program customized to support biomonitoring studies and the needs of the network. The CHEAR PT program developed at Wadsworth will produce well-characterized, matrix-based reference materials containing exogenous and endogenous analytes of interest at critical concentration ranges relevant to biomonitoring that will be shared across the CHEAR lab network.

 描述（由申请人提供）：沃兹沃斯中心儿童健康暴露分析资源（WC-CHEARS）的总体目标是建立一个世界一流的实验室设施，满足NIH资助的研究人员的需求，研究环境污染物对儿童健康的影响。WC-CHESTIC将汇集纽约州卫生部公共卫生实验室和纽约州奥尔巴尼生物医学研究机构与纽约大学医学院生物化学和分子药理学系的巨大资源、能力和专业知识。总之，沃兹沃斯和纽约大学之间的这种伙伴关系将为研究人员提供最先进的专业分析设施，以支持儿童的环境健康研究。沃兹沃斯中心完全根据CLIA-88进行认证，并可支持多项NIH资助的研究，其中将使用基于质谱的技术分析儿童尿液和/或血清中的有机化学污染物，包括但不限于多氯联苯、多环芳烃、氟化化合物、溴化阻燃剂、有机磷杀虫剂、酚类内分泌干扰化学品和邻苯二甲酸酯。实验室还能够分析儿童的生物标本暴露于有毒重金属，包括但不限于铅，镉，汞，和使用最敏感的方法，基于无机质谱。实验室还能够分析儿童血液、血清/血浆和尿液中可能受环境暴露影响的内源性化合物，包括激素、维生素、蛋白质标记物、电解质和代谢物（包括但不限于雌激素、雄激素、睾酮、甲状腺、甘油三酯、胆固醇、维生素D和B12、叶酸、同型半胱氨酸和胰岛素）。沃兹沃斯提供广泛的功能，用于分析非传统基质，例如胎盘、脐带血、婴儿牙齿、干血斑、头发、指甲和唾液中的有机和无机污染物，以支持测量儿童暴露于有毒化学物质的新方法。他们的环境。沃兹沃斯和纽约大学将分享调查非目标化合物的能力和专业知识，这两所大学的广泛能力将相互补充。WC-CHESTIC将受益于沃兹沃斯中心在临床实验室医学领域的国际声誉和领导地位，并作为环境实验室医学，临床化学和毒理学能力验证（PT）计划的组织者。沃兹沃斯在这方面的经验和能力将为NIEHS儿童健康环境分析资源网络提供定制的PT计划，以支持生物监测研究和网络的需求。在沃兹沃斯开发的CHEMPT程序将产生充分表征的、基于基质的参比物质，其中含有与生物监测相关的临界浓度范围内的外源性和内源性目标分析物，这些参比物质将在CHEMPT实验室网络中共享。