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System Genetics of Alcoholism: Network-based Approaches for Genetic Association

酗酒的系统遗传学：基于网络的遗传关联方法

基本信息

批准号：
8891310
负责人：
ROHAN Hugh Craig PALMER
金额：
$ 17.11万
依托单位：
RHODE ISLAND HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2012
资助国家：
美国
起止时间：
2012-08-20 至 2016-07-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8891310
关键词：
Accounting Adult Affect Age Alcohol abuse Alcohol dependence Alcoholism Alcohols Algorithms American Aminobutyric Acids Architecture Attenuated Bayesian Modeling Bioinformatics Biological Biology Biometry Chromosomes, Human, Pair 1 Chromosomes, Human, Pair 5 Collaborations Complex Copy Number Polymorphism Data Databases Diagnosis Diagnostic Disease Drug Addiction EP300 gene Educational workshop Emerging Technologies Environment Environmental Risk Factor Ethnic Origin Event-Related Potentials Future Gender Gene Cluster Gene Proteins Genes Genetic Genetic Polymorphism Genetic Research Genetic Variation Genetic study Genome Genomics Genotype Goals Grant Graph Heterogeneity Individual Institutes Joints K-Series Research Career Programs Knowledge Lead Learning Link Major Depressive Disorder Manuscripts Mental disorders Mentors Mentorship Methods Modeling Molecular Nature Network-based Neural Pathways Pathway interactions Pharmacologic Substance Phenotype Population Predisposition Prevention Problem Solving Public Health Receptor Gene Recruitment Activity Research Research Methodology Research Training Resources Role Sampling Sampling Studies Scientist Single Nucleotide Polymorphism Map Statistical Methods Structure Sum Surveys System Systems Biology Techniques Testing Training Variant alcohol and other drug alcohol use disorder alpha synuclein anti social attenuation base biological systems career cost effective data mining database of Genotypes and Phenotypes drinking endophenotype gene interaction genetic association genetic variant genetics of alcoholism genome sequencing genome wide association study improved innovation meetings network models neurophysiology new technology novel novel strategies programs public health relevance relating to nervous system success theories tool

项目摘要

DESCRIPTION (provided by applicant): This Mentored Research Scientist Career Development Award will afford Dr. Rohan Palmer focused training for his programmatic line of research in the genetics of alcohol dependence and related phenotypes (AD). Given that gene identification studies (in particular genomewide association studies) on alcoholism are challenged by the fact that alcoholism is a multifactorial disorder influenced by multiple interacting genes, each with small effect, the

描述（由申请人提供）：这个指导研究科学家职业发展奖将为罗汉帕尔默博士提供重点培训，以支持他在酒精依赖和相关表型（AD）遗传学方面的计划性研究。鉴于酒精中毒的基因鉴定研究（特别是全基因组关联研究）受到以下事实的挑战，即酒精中毒是一种受多个相互作用的基因影响的多因素疾病，每个基因的影响都很小，