Genomics of blood pressure-induced target organ damage

血压引起的靶器官损伤的基因组学

基本信息

  • 批准号:
    9114651
  • 负责人:
  • 金额:
    $ 417.92万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2015
  • 资助国家:
    美国
  • 起止时间:
    2015-08-01 至 2019-04-30
  • 项目状态:
    已结题

项目摘要

 DESCRIPTION (provided by applicant): Hypertension (HTN) accounts for ~50% of cardiovascular morbidity and mortality, with huge consequences for individuals and society. Despite identifying 100 single nucleotide polymorphisms (SNPs) at 80 loci regulating inter-individual variation in blood pressure (BP) very little of its phenotypic variability has been explained (~1- 2%): nor has its biological pathogenesis, beyond gender, age, BMI and other covariate effects, been understood. This is in contrast to other cardiovascular risk factors such as blood lipids where ~40% of its variance has been explained in recognized biochemical pathways, through the investigation of, in part, much larger numbers of subjects. We propose here to use the unique features of the Kaiser Permanente RPGEH cohort to not only enhance gene discovery by adding >100,000 samples but specifically investigate the clinically important effects of the mapped genes on target organ damage, the clinical pathology induced by hypertension. We emphasize whole genome sequencing of phenotypic extremes from this multi-ethnic US cohort, systematic investigation of both rare and common genetic variation, the use of electronic health records to better define the BP phenotype and target organ damage and address the effect of medications, and, state-of-the-art statistical, computational and annotation analyses to achieve three goals: (1) Whole-genome sequencing (WGS) at blood pressure (BP) extremes to identify large-effect BP alleles in multiple ethnicities from a clinic-based cohort. (2 Identify the genomic contribution of variants to systolic (SBP) and diastolic (DBP) measures and hypertension (HTN) in a multi-ethnic cohort. (3) Construct a multi-locus genetic risk score associated with BP risk and TOD in the same individuals followed across time.


项目成果

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ARAVINDA CHAKRAVARTI其他文献

ARAVINDA CHAKRAVARTI的其他文献

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{{ truncateString('ARAVINDA CHAKRAVARTI', 18)}}的其他基金

Why do Down Syndrome patients have high risk of Hirschsprung disease?
为什么唐氏综合症患者患先天性巨结肠的风险很高?
  • 批准号:
    10528177
  • 财政年份:
    2022
  • 资助金额:
    $ 417.92万
  • 项目类别:
Cardiac genetic effects across HLBS phenotypes
HLBS 表型的心脏遗传效应
  • 批准号:
    9521873
  • 财政年份:
    2018
  • 资助金额:
    $ 417.92万
  • 项目类别:
Genomics of blood pressure-induced target organ damage
血压引起的靶器官损伤的基因组学
  • 批准号:
    9260062
  • 财政年份:
    2015
  • 资助金额:
    $ 417.92万
  • 项目类别:
Genomics of blood pressure-induced target organ damage
血压引起的靶器官损伤的基因组学
  • 批准号:
    8942053
  • 财政年份:
    2015
  • 资助金额:
    $ 417.92万
  • 项目类别:
Genetic Analysis of Hirschsprung Disease
先天性巨结肠症的遗传分析
  • 批准号:
    8819621
  • 财政年份:
    2015
  • 资助金额:
    $ 417.92万
  • 项目类别:
Genetic Analysis of Hirschsprung Disease
先天性巨结肠症的遗传分析
  • 批准号:
    9262256
  • 财政年份:
    2015
  • 资助金额:
    $ 417.92万
  • 项目类别:
GWAS TO GENE FUNCTION: NOS1AP AND OTHER QT INTERVAL GENES
GWAS 与基因功能:NOS1AP 和其他 QT 间期基因
  • 批准号:
    8904675
  • 财政年份:
    2014
  • 资助金额:
    $ 417.92万
  • 项目类别:
GWAS TO GENE FUNCTION: NOS1AP AND OTHER QT INTERVAL GENES
GWAS 与基因功能:NOS1AP 和其他 QT 间期基因
  • 批准号:
    9113648
  • 财政年份:
    2014
  • 资助金额:
    $ 417.92万
  • 项目类别:
GWAS TO GENE FUNCTION: NOS1AP AND OTHER QT INTERVAL GENES
GWAS 与基因功能:NOS1AP 和其他 QT 间期基因
  • 批准号:
    8625164
  • 财政年份:
    2014
  • 资助金额:
    $ 417.92万
  • 项目类别:
GWAS to Gene Function: NOS1AP and Other QT Interval Genes
GWAS 与基因功能:NOS1AP 和其他 QT 间期基因
  • 批准号:
    9671234
  • 财政年份:
    2014
  • 资助金额:
    $ 417.92万
  • 项目类别:

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Multilevel Community-Based Mental Health Intervention to Address Structural Inequities and Adverse Disparate Consequences of COVID-19 Pandemic on Latinx Immigrants and African Refugees
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