Neural Habituation in Ultra High-Risk Youth

项目摘要 当前项目的总体目标是检查神经习惯化与定义的 由于神经对重复的视觉刺激(尤其是人脸)的反应减少，以及 超高风险(UHR)青年，这是一个面临精神病危险的群体。尽管社会的不同方面 对UHR年轻人的加工和神经生物学进行了相对孤立的研究，目前的建议是 值得注意的是，从行为识别能力到感知过程，跨多个模式的链接 真实世界的功能和临床变量。拟议研究的第一个目标是利用 脑电(EEG)测试UHR青年存在神经习服缺陷的假说 相对于健康对照组。这一点特别重要，因为习惯化和习惯性 学习和记忆。之前的研究已经显示精神分裂症患者存在缺陷，但这些 在精神病发作之前就存在缺陷还有待检查。第二个主要目标将审查 神经习惯化是否与面孔身份识别、面孔情感识别或一般非 社交对象识别。为了做到这一点，拟议的研究将使用行为识别任务和 研究第一个目标中测试的认知能力和神经习惯化之间的相关性。目标3将 检查神经习惯化和行为识别能力(面部认同感、面部情感、 和非社交对象)与症状严重性、认知测量和临床变量相关 初步评估。最后，一个探索性目标将检查目标1和目标2中评估的措施 随时间变化和/或预测12个月后的临床状态和社会功能。正在研究的 这一人群潜在的社会缺陷的机制将为未来的干预提供一个框架，例如 作为脸部训练疗法。

Project Summary The overall objective of the current project is to examine the relationship between neural habituation, defined as a decrease in neural response to repeated visual stimuli (especially faces), and social processing deficits in ultra high-risk (UHR) youth, a group at imminent risk for psychosis. Although different aspects of social processing and neurobiology in UHR youth have been examined in relative isolation, the current proposal is notable in linking across multiple modalities from behavioral recognition abilities to perceptual processes to real-world functioning and clinical variables. The first aim of the proposed research is to utilize electroencephalography (EEG) to test the hypothesis that neural habituation deficits are present in UHR youth relative to healthy controls. This is of particular importance due to the association between habituation and learning and memory. Previous work has shown deficits in patients with schizophrenia, but whether these deficits are present prior to the onset of psychosis has yet to be examined. The second main aim will examine whether neural habituation is associated with face identity recognition, facial affect recognition, or general non- social object recognition. To do so, the proposed research will employ behavioral recognition tasks and examine the correlates between recognition abilities and neural habituation as tested in the first aim. Aim 3 will examine the degree to which neural habituation and behavioral recognition abilities (face identity, facial affect, and non-social object) are associated with symptom severity, cognitive measures, and clinical variables at initial assessment. Finally, an Exploratory Aim will examine which of the measures assessed in Aims 1 and 2 change over time and/or predict clinical status and social functioning 12-months later. Studying the mechanisms underlying social deficits in this population will provide a framework for future interventions, such as face-training remediations.