Neural Habituation in Ultra High-Risk Youth

项目摘要 当前项目的总体目标是研究神经习惯化之间的关系， 神经对重复视觉刺激（尤其是面孔）的反应减少， 超高危（UHR）青年，一组在精神病的迫在眉睫的风险。虽然社会的不同方面 UHR青年的处理和神经生物学已经在相对孤立的情况下进行了研究，目前的建议是 值得注意的是，从行为识别能力到感知过程， 真实世界的功能和临床变量。本研究的第一个目的是利用 脑电图（EEG）来检验UHR青年存在神经习惯性缺陷的假设 相对于健康对照。这是特别重要的，因为习惯化和 学习和记忆。以前的研究表明精神分裂症患者存在缺陷，但这些缺陷是否 在精神病发作之前就存在的缺陷还有待研究。第二个主要目标将审查 神经习惯化是否与面部身份识别、面部情感识别或一般非面部情感识别相关？ 社会对象识别为此，拟议的研究将采用行为识别任务， 检查在第一个目标中测试的识别能力和神经习惯之间的相关性。目标3将 检查神经习惯化和行为识别能力（面部身份，面部情感， 和非社会对象）与症状严重程度、认知测量和临床变量相关， 初步评估。最后，探索性目标将检查目标1和目标2中评估的措施 随时间变化和/或预测12个月后的临床状态和社会功能。研究 这一人群社会缺陷的潜在机制将为未来的干预措施提供一个框架， 作为面部训练的补救措施

Project Summary The overall objective of the current project is to examine the relationship between neural habituation, defined as a decrease in neural response to repeated visual stimuli (especially faces), and social processing deficits in ultra high-risk (UHR) youth, a group at imminent risk for psychosis. Although different aspects of social processing and neurobiology in UHR youth have been examined in relative isolation, the current proposal is notable in linking across multiple modalities from behavioral recognition abilities to perceptual processes to real-world functioning and clinical variables. The first aim of the proposed research is to utilize electroencephalography (EEG) to test the hypothesis that neural habituation deficits are present in UHR youth relative to healthy controls. This is of particular importance due to the association between habituation and learning and memory. Previous work has shown deficits in patients with schizophrenia, but whether these deficits are present prior to the onset of psychosis has yet to be examined. The second main aim will examine whether neural habituation is associated with face identity recognition, facial affect recognition, or general non- social object recognition. To do so, the proposed research will employ behavioral recognition tasks and examine the correlates between recognition abilities and neural habituation as tested in the first aim. Aim 3 will examine the degree to which neural habituation and behavioral recognition abilities (face identity, facial affect, and non-social object) are associated with symptom severity, cognitive measures, and clinical variables at initial assessment. Finally, an Exploratory Aim will examine which of the measures assessed in Aims 1 and 2 change over time and/or predict clinical status and social functioning 12-months later. Studying the mechanisms underlying social deficits in this population will provide a framework for future interventions, such as face-training remediations.