REPOSITORY SERVICES FOR THE MATERNAL AND PEDIATRIC INFECTIOUS DISEASES BRANCH SPECIMENS

孕产妇和儿童传染病分支标本保藏服务

• 批准号: 9536544
• 负责人: CHRISTOPHER PARSONS
• 金额: $ 43.13万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-09-09 至 2017-09-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9536544
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adipose tissue; Adolescent; Amniotic Fluid; Blood; Candida; Cell Extracts; Cells; Cervical; Child; Childhood; Clinical; Clinical Trials; Cohort Studies; Communicable Diseases; Contracts; Cryopreserved Cell; DNA; Data; Dental Plaque; Dose; Drug Kinetics; Endometrial; Equipment and supply inventories; Erythrocytes; Foundations; Freezing; Funding; Future; Goals; HIV; HIV Infections; HIV therapy; HIV-exposed uninfected infant; Human; IMPAACT; Infant; Infection; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Liquid substance; Meconium; Monitor; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; Participant; Perinatal; Pharyngeal structure; Placenta; Plasma; Population; Pregnant Women; Prevention; Protocols documentation; Public Health Schools; Research; Safety; Saliva; Science; Serum; Services; Ships; Site; Specimen; Spottings; Swab; Symptoms; System; Technology; Temperature; Tissues; Umbilical Cord Blood; United States; Urine; Vagina; Vertical Disease Transmission; Youth; antiretroviral therapy; base; blood lipid; combat; cytokine; data management; frontier; neutrophil; operation; pediatric human immunodeficiency virus; programs; repository; support network; young woman

The NICHD Human BioSpecimen Repository shall provide the services of storage, monitoring, and distribution for the Maternal and Pediatric Infectious Disease Branch (MPIDB). Required repository services therefore include planning discussions with repository staff to adequately prepare for specimens, receipt of specimens from multiple clinical centers, purchase of freezers to store the specimens, storage of the specimens at the required temperatures; an on-line, searchable inventory system of all specimens, and shipment of biospecimens to analytical labs. The Maternal and Pediatric Infectious Disease Branch (MPIDB) promotes research to investigate the impact of HIV and its treatment on specific populations (pregnant women, infants, children, and adolescents) with the goal of increasing our understanding so we can better combat this infection. There are two main networks supported by the MPIDB that actively collect specimens to be housed in the NICHD repository. These are PHACS (Pediatric HIV AIDS Cohort Study) and IMPMCT (International Maternal Pediatric and Adolescent AIDS Clinical Trials). The Pediatric HIV AIDS Cohort Study (PHACS) is a multicenter United States-based program that follows both perinatally HIV-infected youth and HIV-exposed/uninfected infants, children, and youth. The IMPAACT Network is focused on evaluating potential therapies for HIV infection and its related symptoms in infants, children, adolescents, and pregnant women, including clinical trials of HIV/AIDS interventions for and prevention of mother-to-child transmission. The research agenda includes studies on the pharmacokinetics, safety, optimal dosing, and long-term complications of new antiretroviral (ARV) therapies for HIV/AIDS in pediatric and adolescent populations and in pregnant women. NICHD-funded sites (via Westat contract) utilize the NICHD repository; NIAID-funded sites utilize a separate NIAID-supported repository. NICHD­ supported sites also perform other trials independently or within other networks. PHACS collects/stores the following types of specimens from the over 3000 participants currently being followed on 3 main protocols and additional substudies:

NICHD人类生物样品储存库应提供储存、监测和 母婴传染病科(MPIDB)的分布。因此，所需的储存库服务包括规划与储存库工作人员的讨论以充分准备标本、接收来自多个临床中心的标本、购买冷冻箱以储存标本、在所需温度下储存标本、建立所有标本的在线、可搜索的库存系统以及将生物标本运送到分析实验室。 母婴传染病科(MPIDB)促进研究，以调查艾滋病毒及其治疗对特定人群(孕妇、婴儿、儿童和青少年)的影响，目的是增加我们的了解，以便我们能够更好地抗击这种感染。MPIDB支持两个主要网络，它们积极收集标本，存放在NICHD储存库中。这些是PHACS(儿科艾滋病毒 艾滋病队列研究)和国际母儿和青少年艾滋病防治方案 临床试验)。 儿科艾滋病毒艾滋病队列研究(PHACS)是一项总部设在美国的多中心计划，跟踪调查围产期感染艾滋病毒的青年和感染艾滋病毒/未感染艾滋病毒的婴儿、儿童和青年。 艾滋病毒/艾滋病综合防治网络的重点是评估针对婴儿、儿童、青少年和孕妇的艾滋病毒感染及其相关症状的潜在治疗方法，包括艾滋病毒/艾滋病干预措施和预防母婴传播的临床试验。研究议程包括对儿童和青少年人群以及孕妇中艾滋病毒/艾滋病的抗逆转录病毒(ARV)新疗法的药代动力学、安全性、最佳剂量和长期并发症的研究。NICHD资助的网站(通过WESTAT合同)使用NICHD储存库；NIAID资助的网站使用NIAID支持的单独储存库。NICHD支持的网站还独立或在其他网络内进行其他试验。 PHACS收集/存储了目前正在进行3项主要方案和其他子研究的3000多名参与者的以下类型的标本：