REPOSITORY SERVICES FOR THE MATERNAL AND PEDIATRIC INFECTIOUS DISEASES BRANCH SPECIMENS

孕产妇和儿童传染病分支标本保藏服务

• 批准号: 10013060
• 负责人: CHRISTOPHER PARSONS
• 金额: $ 40.72万
• 依托单位: FISHER BIOSERVICES, INC.
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-09 至 2020-09-08
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10013060
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adipose tissue; Adolescent; Amniotic Fluid; Blood; Candida; Cell Extracts; Cells; Cervical; Child; Childhood; Clinical; Clinical Trials; Cohort Studies; Communicable Diseases; Contracts; Cryopreserved Cell; DNA; Data; Dental Plaque; Dose; Drug Kinetics; Endometrial; Equipment and supply inventories; Erythrocytes; Foundations; Freezing; Funding; Future; Goals; HIV; HIV Infections; HIV therapy; HIV-exposed uninfected infant; Human; IMPAACT; Infant; Infection; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Liquid substance; Meconium; Monitor; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; Participant; Peripheral Blood Mononuclear Cell; Pharyngeal structure; Placenta; Plasma; Population; Pregnant Women; Prevention; Protocols documentation; Public Health Schools; Research; Safety; Saliva; Science; Serum; Services; Ships; Site; Specimen; Spottings; Swab; Symptoms; System; Technology; Temperature; Tissues; Umbilical Cord Blood; United States; Urine; Vagina; Vertical Disease Transmission; Youth; antiretroviral therapy; base; blood lipid; combat; cytokine; data management; frontier; neutrophil; operation; pediatric human immunodeficiency virus; perinatal HIV; programs; repository; support network; young woman

The NICHD Human BioSpecimen Repository shall provide the services of storage, monitoring, and distribution for the Maternal and Pediatric Infectious Disease Branch (MPIDB). Required repository services therefore include planning discussions with repository staff to adequately prepare for specimens, receipt of specimens from multiple clinical centers, purchase of freezers to store the specimens, storage of the specimens at the required temperatures; an on-line, searchable inventory system of all specimens, and shipment of biospecimens to analytical labs. The Maternal and Pediatric Infectious Disease Branch (MPIDB) promotes research to investigate the impact of HIV and its treatment on specific populations (pregnant women, infants, children, and adolescents) with the goal of increasing our understanding so we can better combat this infection. There are two main networks supported by the MPIDB that actively collect specimens to be housed in the NICHD repository. These are PHACS (Pediatric HIV AIDS Cohort Study) and IMPMCT (International Maternal Pediatric and Adolescent AIDS Clinical Trials). The Pediatric HIV AIDS Cohort Study (PHACS) is a multicenter United States-based program that follows both perinatally HIV-infected youth and HIV-exposed/uninfected infants, children, and youth. The IMPAACT Network is focused on evaluating potential therapies for HIV infection and its related symptoms in infants, children, adolescents, and pregnant women, including clinical trials of HIV/AIDS interventions for and prevention of mother-to-child transmission. The research agenda includes studies on the pharmacokinetics, safety, optimal dosing, and long-term complications of new antiretroviral (ARV) therapies for HIV/AIDS in pediatric and adolescent populations and in pregnant women. NICHD-funded sites (via Westat contract) utilize the NICHD repository; NIAID-funded sites utilize a separate NIAID-supported repository. NICHD­ supported sites also perform other trials independently or within other networks. PHACS collects/stores the following types of specimens from the over 3000 participants currently being followed on 3 main protocols and additional substudies:

NICHD人类生物标本库应提供储存、监测和